Protein Alignment IntS11 and cpsf3

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001006770.1
• Gene: cpsf3 / 448456
• XenbaseID: XB-GENE-972322
• Length: 692
• Species: Xenopus tropicalis
• Alignment Length: 633
• Identity: 220/633 - (34%)
• Similarity: 334/633 - (52%)
• Gaps: 86/633 - (13%)

  Fly     6 ITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSHIDCVIISHFH 70
            |.||||||:|||||::|...|:.||||||:|.|.......|....|.|     :.||.::|||||
 Frog    21 IRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDP-----AEIDLLLISHFH 80

  Fly    71 LDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQMIKDCMKKVIP 135
            ||||||||:..:...:.|..:|||.||||...||.|..||: ....:...:|...:::.|.|:..
 Frog    81 LDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVS-NISADDMLYTETDLEESMDKIET 144

  Fly   136 VTLHQSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLL 200
            :..|:...| ..::...|:||||||||||.|::....::||||::...||||.||.|...:||:|
 Frog   145 INFHEVKEV-AGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNVKPDIL 208

  Fly   201 ISESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMNLKY-- 263
            |.||||.|.|.:.:..||..|...||:.|.:||:.|||||||||||||.::|:.||:.....:
 Frog   209 IIESTYGTHIHEKREEREARFCNTVHDIVNRGGRALIPVFALGRAQELLLILDEYWQNHPELHDI 273

  Fly   264 PIYFALGLTEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHI---KPFDKAYIDNPGAMVVFATP 325
            |||:|..|.:|....|:.::...|.||||.....|.|.||||   |..|  :.|:.|..||.|:|
 Frog   274 PIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMD--HFDDIGPSVVMASP 336

  Fly   326 GMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFS 390
            ||:.:|||.::|:.|..::.|.||:.||||:||:...|:...:::...:.|.:.:||:|:|:|||
 Frog   337 GMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEIATMSGQKLPLKMSVDYISFS 401

  Fly   391 AHADAKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKI------KDEFNLETYMPANGETCVIS-T 448
            ||.|.:...:.::..:|.:|:|||||..:|..|::.:      .||..:|.:.|.|.|...:: .
 Frog   402 AHTDYQQTSEFVRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVEIEVHNPRNTEAVTLNFR 466

  Fly   449 PVKIPVDASVSLLKAEARSYNAQPPDPKRRRLIHGVLVMKD------------------------ 489
            ..|:   |.|..|.|:.:        |::.:.|.|:||.::
 Frog   467 GEKL---AKVMGLLADKK--------PEQGQRISGILVKRNFNYHILCPSDLSSYTDLAMSTVTQ 520

  Fly   490 ----------NRI--MLQNLTDALKEIGIN-RHVMR-FTSKVKMDDSGPVIRTSERLKTLLEEKL 540
                      |.:  .||.||..::||.:| :..:| |.:...:.|:|.|         .||
 Frog   521 KQAIPYTGPFNLLSCQLQQLTGDVEEIEVNEKDALRVFKAVTVVRDAGMV---------YLE--- 573

  Fly   541 AGWTVTMQENGSIAIESVEVKVEEDEKDPKQKNILISWTNQDEDIGAY 588
              | |....|...| ::|...:.|.:.:||....:.:..:::.|:.||
 Frog   574 --W-VANPANDMYA-DTVITVILELQSNPKANKAVATRASKEVDMDAY 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	174/414 (42%)
		INTS11-like_MBL-fold	6..204	CDD:293849	85/197 (43%)
cpsf3	NP_001006770.1	CPSF3-like_MBL-fold	19..212	CDD:293850	85/197 (43%)
		YSH1	21..428	CDD:440849	175/415 (42%)
		CPSF73-100_C	486..689	CDD:463330	30/148 (20%)