Protein Alignment IntS11 and Cpsf73

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 610
• Identity: 211/610 - (34%)
• Similarity: 320/610 - (52%)
• Gaps: 79/610 - (12%)

  Fly     1 MPD-----IKITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSH 60
            |||     ::|.||||||:|||||::|...||.||||||:|.|.:.....|....|..:     .
  Fly    10 MPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEAD-----E 69

  Fly    61 IDCVIISHFHLDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQM 125
            ||.:.|||||||||||||:......:.|..:|||.||||...:|.|..|:       ||..|.||
  Fly    70 IDLLFISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKI-------SNISTEQM 127

  Fly   126 ------IKDCMKKVIPVTLHQSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPD 184
                  ::..|:|:..:..|:...| ..:...||.||||||||||.|::....::||||::...|
  Fly   128 LYTEADLEASMEKIETINFHEERDV-MGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQED 191

  Fly   185 RHLGAAWIDKCRPDLLISESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELC 249
            |||.||.:...:||:||:||||.|.|.:.:..||..|...|.:.|.:||:.|||||||||||||.
  Fly   192 RHLMAAEVPPMKPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELL 256

  Fly   250 ILLETYW-ERMNL-KYPIYFALGLTEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHI---KPFD 309
            ::|:.:| :..:| :.|||:|..|.:|....|:.:|...|.:||:.....|.|.|:||   |..|
  Fly   257 LILDEFWSQNPDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKGID 321

  Fly   310 KAYIDNPGAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKKVEFEN 374
              :.::.|..|:.|:|||:.:|||.::|:.|..:..|.||:.||||:||:...:|...:::...:
  Fly   322 --HFEDIGPCVIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLS 384

  Fly   375 RQVVEVKMAVEYMSFSAHADAKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKIKDEF------NL 433
            .|.:.:.|:|:|:|||||.|.:...:.|:..:|.:|:|||||..:|..|:..::.|:      ::
  Fly   385 GQKLPLNMSVDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDI 449

  Fly   434 ETYMPAN---------GETCVISTPVKIPVDASVSLLKAEARSYNAQPPDPKRRRLIHGVLVMKD 489
            :.|.|.|         ||...       .|..|::...:|..|            .:.||||.:|
  Fly   450 KFYNPRNTHAVDLYFRGEKTA-------KVMGSLAAKNSEVGS------------KLSGVLVKRD 495

  Fly   490 NRIMLQNLTDALKEIGINRHVMRFTSKVKMDDSGPVIRTSERLKTLLEEKLAGWTVTMQENGSIA 554
            .:..|...:|      :.::.....|.|....|.|...:...|:.||:...||....::....:.
  Fly   496 FKYHLLAPSD------LGKYTDMSMSVVTQRQSIPWGSSLSTLELLLDRIGAGCVEVLEAERKLR 554

  Fly   555 I-ESVEVKVEEDEKDPKQKNILISW 578
            : ..:|:.||       ||.|::.|
  Fly   555 VFGCIELTVE-------QKIIVMEW 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	171/421 (41%)
		INTS11-like_MBL-fold	6..204	CDD:293849	87/203 (43%)
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	87/205 (42%)
		YSH1	19..427	CDD:440849	172/422 (41%)
		CPSF73-100_C	486..680	CDD:463330	23/100 (23%)