DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IntS11 and cpsf3

DIOPT Version :9

Sequence 1:	NP_651721.1	Gene:	IntS11 / 43506	FlyBaseID:	FBgn0039691	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001003836.1	Gene:	cpsf3 / 324554	ZFINID:	ZDB-GENE-030131-3275	Length:	690	Species:	Danio rerio

Alignment Length:	631	Identity:	219/631 - (34%)
Similarity:	329/631 - (52%)	Gaps:	74/631 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSHIDCVIISHFH 70
            |.||||||:|||||::|...|:.||:|||:|.|.......|....|.|     :.||.::|||||
Zfish    21 IRPLGAGQEVGRSCIILEFKGRKIMVDCGIHPGLEGMDALPYIDLIDP-----AEIDLLLISHFH 80

  Fly    71 LDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQMIKDCMKKVIP 135
            ||||||||:..:...:.|..:|||.||||...||.|..||: ....:...:|...:::.|.|:..
Zfish    81 LDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVS-NISADDMLYTETDLEESMDKIET 144

  Fly   136 VTLHQSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLL 200
            :..|:...| ..::...|:||||||||||.|::....::||||::...||||.||.|...:||:|
Zfish   145 INFHEVKEV-AGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPSVKPDIL 208

  Fly   201 ISESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMNLKY-- 263
            |:||||.|.|.:.:..||..|...||:.|.:.|:.|||||||||||||.::|:.||:.....:
Zfish   209 ITESTYGTHIHEKREEREARFCNTVHDIVNREGRCLIPVFALGRAQELLLILDEYWQNHPELHDI 273

  Fly   264 PIYFALGLTEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHI---KPFDKAYIDNPGAMVVFATP 325
            |||:|..|.:|....|:.::...|.||||.....|.|.||||   |..|  :.|:.|..||.|:|
Zfish   274 PIYYASSLAKKCMAVYQTYVNAMNDKIRKAININNPFVFKHISNLKSMD--HFDDIGPSVVMASP 336

  Fly   326 GMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFS 390
            ||:.:|||.::|:.|..::.|.||:.||||:||:...|:...:::...:.|.:.:||:|:|:|||
Zfish   337 GMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFS 401

  Fly   391 AHADAKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKI------KDEFNLETYMPANGETCVISTP 449
            ||.|.:...:.|:..:|.:|:|||||..:|..|::.:      .||.::|.:.|.|.|...::..
Zfish   402 AHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFR 466

  Fly   450 VKIPVDASVSLLKAEARSYNAQPPDPKRRRLIHGVLVMKD--NRIM----LQNLTDALKEIGINR 508
            .:.......||  |:.:....|        .:.|:||.|:  ..|:    |.|.||.........
Zfish   467 GEKLAKVMGSL--ADKKCSQGQ--------RVSGILVKKNFSYHILSPSDLSNYTDLAMSTVKQT 521

  Fly   509 HVMRFTSKVKMDDSGPVIRTSERLKTL---LEE---------KLAGWTVTMQENGSIAIE----- 556
            ..:.||        ||......:|:.|   :||         |:......:.||..:.:|
Zfish   522 QAIPFT--------GPFPLLLSQLRHLTGDVEEIEMSEKSTVKVFNSITVIHENNLVVLEWFANP 578

  Fly   557 -------SVEVKVEEDEKDPKQKNILISWTNQDEDIGAYILNVLQN 595
                   :|...|.|.:.:||.:..|   ..|::.:.   :||.||
Zfish   579 LNDMYADAVTTVVLEVQSNPKAQKAL---QPQEKKVD---VNVFQN 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	4..446	CDD:224157	183/450 (41%)
		INTS11-like_MBL-fold	6..204	CDD:293849	84/197 (43%)
		Beta-Casp	245..363	CDD:214983	49/122 (40%)
		RMMBL	376..416	CDD:284853	17/39 (44%)
cpsf3	NP_001003836.1	CPSF3-like_MBL-fold	19..212	CDD:293850	84/197 (43%)
		YSH1	21..461	CDD:224157	183/448 (41%)
		Beta-Casp	253..374	CDD:214983	49/122 (40%)
		RMMBL	387..427	CDD:284853	17/39 (44%)
		CPSF73-100_C	485..638	CDD:288554	33/156 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53735
OrthoDB	1	1.010	-	-		D210835at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830