DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS11 and Ints11

DIOPT Version :9

Sequence 1:	NP_651721.1	Gene:	IntS11 / 43506	FlyBaseID:	FBgn0039691	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_006239611.1	Gene:	Ints11 / 298688	RGDID:	1306841	Length:	629	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	406/606 - (66%)
Similarity:	478/606 - (78%)	Gaps:	25/606 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPDIKITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSHIDCVI 65
            ||:|::|||||||||||||:|:|:.|||:||||||||||||:|||||||||...|.:|..:||||
  Rat     2 MPEIRVTPLGAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDFLDCVI 66

  Fly    66 ISHFHLDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQMIKDCM 130
            ||||||||||||||.||:|||.|||||||||:||.||||||.||:||::|||:||||:|||||||
  Rat    67 ISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCM 131

  Fly   131 KKVIPVTLHQSMMVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKC 195
            |||:.|.|||::.||.:|||||||||||||||||.|||||:||||||||||||||||||||||||
  Rat   132 KKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKC 196

  Fly   196 RPDLLISESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMN 260
            ||:|||:|||||||||||||||||||||||||.|.:|||||||||||||||||||||||:|||||
  Rat   197 RPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMN 261

  Fly   261 LKYPIYFALGLTEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHIKPFDKAYIDNPGAMVVFATP 325
            ||.||||:.|||||||.|||:||||||||||||||.||||:|||||.||:.:.||||.|||||||
  Rat   262 LKVPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRTFADNPGPMVVFATP 326

  Fly   326 GMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFS 390
            ||||||.|||||:|||.||.|||||||||||||||:|||.|.:|:|.|.||::||||.|||||||
  Rat   327 GMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQMLEVKMQVEYMSFS 391

  Fly   391 AHADAKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKIKDEFNLETYMPANGETCVISTPVKIPVD 455
            |||||||||||:...||::|:||||||.||:|||.||:.||.:..||||||||..:.|...|||.
  Rat   392 AHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLRQKIEQEFRVSCYMPANGETVTLPTSPSIPVG 456

  Fly   456 ASVSLLKAE------------ARS-------------YNAQPPDPKRRRLIHGVLVMKDNRIMLQ 495
            .|:.|||.|            :|.             :....|:.|:.||:||.|:||||...|.
  Rat   457 ISLGLLKREMVQGMKGRLGHGSRGQVTGGWVDCIIPFFTGLLPEAKKPRLLHGTLIMKDNNFRLV 521

  Fly   496 NLTDALKEIGINRHVMRFTSKVKMDDSGPVIRTSERLKTLLEEKLAGWTVTMQENGSIAIESVEV 560
            :...||||:|:..|.:|||.:|.:.|:.....|:.|:.:.|:..|....|....:||:.:||:.:
  Rat   522 SSEQALKELGLAEHQLRFTCRVHLQDTRKEQETALRVYSHLKSTLKDHCVQHLPDGSVTVESILI 586

  Fly   561 KVEEDEKDPKQKNILISWTNQ 581
            :.....:||..|.:|:|||.|
  Rat   587 QAAAHSEDPGTKVLLVSWTYQ 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	4..446	CDD:224157	354/441 (80%)
		INTS11-like_MBL-fold	6..204	CDD:293849	159/197 (81%)
		Beta-Casp	245..363	CDD:214983	98/117 (84%)
		RMMBL	376..416	CDD:284853	29/39 (74%)
Ints11	XP_006239611.1	YSH1	5..445	CDD:224157	353/439 (80%)
		INTS11-like_MBL-fold	7..205	CDD:293849	159/197 (81%)
		Beta-Casp	246..364	CDD:214983	98/117 (84%)
		RMMBL	377..417	CDD:284853	29/39 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353860
Domainoid	1	1.000	305	1.000	Domainoid score	I1323
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9894
Inparanoid	1	1.050	852	1.000	Inparanoid score	I411
OMA	1	1.010	-	-		QHG53735
OrthoDB	1	1.010	-	-		D210835at33208
OrthoFinder	1	1.000	-	-		FOG0006201
OrthoInspector	1	1.000	-	-		oto98234
orthoMCL	1	0.900	-	-		OOG6_102863
Panther	1	1.100	-	-	LDO	PTHR11203
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4481
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770