Protein Alignment IntS11 and Ints9

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_700463.3
• Gene: Ints9 / 210925
• MGIID: 1098533
• Length: 658
• Species: Mus musculus
• Alignment Length: 683
• Identity: 146/683 - (21%)
• Similarity: 237/683 - (34%)
• Gaps: 201/683 - (29%)

  Fly    19 CLLLSMGGKNIMLDCGMHM---------------------GYN--DERRFPD----------FSY 50
            |.:|......||||||:.|                     |::  |...|.|          |..
Mouse    14 CNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVD 78

  Fly    51 IVPEG--PIT-----SHIDCVIISHFHLDHC-GALPYMSEIVGYTGPIYMTHPTKAIAPILLEDM 107
            .|||.  |.|     |.:|.::||::   || .||||::|..|:||.:|.|.||..|..:|:|::
Mouse    79 SVPEFCLPETELIDLSTVDVILISNY---HCMMALPYITEHTGFTGTVYATEPTMQIGRLLMEEL 140

  Fly   108 ----------------------------RKVAVERKGESNFFTTQMIKDCMKKVIPVTLHQSMMV 144
                                        .|.|||.......:|.|.:...:.|:..|...|.:.:
Mouse   141 VNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIEL 205

  Fly   145 DTDLEIKAYYAGHVLGAAMFWIKVGSQSVVY-TGDYNMTPDRH---------------LGAAWID 193
            ...:::....:|:.||::.:.|:...:.|.| :|...:|....               .|...|.
Mouse   206 FGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLILTGLTQIP 270

  Fly   194 KCRPDLLISE--STYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYW 256
            ...||.::.|  |..|.|:|:                   ||.||:|.:..|...:|...|..|.
Mouse   271 TANPDGMVGEFCSNLALTVRN-------------------GGNVLVPCYPSGVIYDLLECLYQYI 316

  Fly   257 ERMNL-KYPIYFALGLTEKANTYYKMFITW-TNQKIRKT------FVHRNMFDFKHIKPFDKAYI 313
            :...| ..|.||...:...:..:.::|..| .:.|..|.      |.|..:.....:|.:...:.
Mouse   317 DSAGLSNIPFYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYRSIHG 381

  Fly   314 D------NPGAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPG-------------------- 352
            |      .|  .|:|.....|..|..:...:.|..:..|.:|...
Mouse   382 DFSNDFRQP--CVLFTGHPSLRFGDVVHFMELWGKSSLNTIIFTEPDFSYLEALAPYQPLAMKCI 444

  Fly   353 YCVQGTVGNKILGGAKKVEFENRQVVEVKMAVEYMSFSAHADAKGIMQLIQNCEPKNVMLVHGEA 417
            ||...|..|.|.......|.:...||..:...:.....||.     |.|:.:|:|..:.....|.
Mouse   445 YCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQAHR-----MDLMIDCQPPAMSYRRAEV 504

  Fly   418 GKMKFLRSKIKDEFNLETYMPANGETCVISTPVKIPVDASVSLLKAEARSYNAQPPDPKRRRLIH 482
            ..:.|.|...|.|.     ||...::.|   |::|....|::.:.|
Mouse   505 LALPFKRRYEKIEI-----MPELADSLV---PMEIKPGISLATVSA------------------- 542

  Fly   483 GVLVMKDNRIMLQ------NLTDALKEIGINRHVMRF-TSKVKMDDSGPV---IRTSER-----L 532
             ||..|||:.:||      ..|.:.|...:|..:... ..|..:..|.||   ::|.|:     :
Mouse   543 -VLHTKDNKHVLQPPPKPTQPTSSKKRKRVNEDIPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDI 606

  Fly   533 KTLLEEKLAGWTVTMQENGSIAIESVEVKVEED 565
            |  :|:...|..|.:||..::      :::|||
Mouse   607 K--VEDTAKGHIVLLQEAETL------IQIEED 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	109/517 (21%)
		INTS11-like_MBL-fold	6..204	CDD:293849	62/271 (23%)
Ints9	NP_700463.3	Int9-like_MBL-fold	1..265	CDD:293852	57/253 (23%)
		Beta-Casp	307..425	CDD:214983	23/119 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..572		6/23 (26%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NV88	566..570		1/3 (33%)