Protein Alignment IntS11 and ints-9

DIOPT Version :10

• Sequence 1: NP_651721.1
• Gene: IntS11 / 43506
• FlyBaseID: FBgn0039691
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_504953.1
• Gene: ints-9 / 179142
• WormBaseID: WBGene00017608
• Length: 646
• Species: Caenorhabditis elegans
• Alignment Length: 686
• Identity: 124/686 - (18%)
• Similarity: 246/686 - (35%)
• Gaps: 195/686 - (28%)

  Fly    17 RSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYI--------VPEGPITSH------------- 60
            :.|.||......|::|..:..       .|.||::        :...||...
 Worm    12 KPCFLLEWPNARILMDTPIDF-------TPFFSFLPHVYQSPRIKNAPIAKKFQIPYLKELGNRV 69

  Fly    61 --------------------IDCVIISHFHLDHCGALPYMSEIVGYTGPIYMTHPTKAIAPILLE 105
                                ||.:::|::  :....||:.:|..|::|.||:|........:|:|
 Worm    70 YVESPPEIFHVSTDMLKMDTIDAILVSNY--ESFVGLPFYTEGSGFSGKIYVTEIAYQYGKLLME 132

  Fly   106 DM----RKVAV---ERKGESN-------------------FFTTQMIKDCMKKVIPVTLHQSMMV 144
            :|    .::.|   ::|.:..                   ::||..:..|:.|||.::.:|::
 Worm   133 EMLEFISRIEVLPSDKKWKREEFCGKFPNPPFQNPVEWRPYYTTTDMHSCLAKVITLSFNQTI-- 195

  Fly   145 DTDL---EIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYN--MTPDRHLGAAWIDKCRPDLLISES 204
              ||   ::....:||..|:|.:.||..::...|....|  .|..:.:..|.:......|:.|.|
 Worm   196 --DLFRIKVTPVVSGHTYGSAYWTIKTENEQFAYLSASNPSATDVKLMETAPLRAVDHILVTSLS 258

  Fly   205 TYATTIRDSKRCRERDF--LKKVHECVAKGGKVLIPVFALGRAQELCILLE---TYWERMNLKYP 264
            ....|     ..:|..:  :|.:.:.:.|.|.||:|:..:|...|:...:.   |....:.|..|
 Worm   259 RLVDT-----TAKEMGYSLIKTITDVLKKHGSVLLPICPVGPIFEMIEAVSDIITTTNGIPLDTP 318

  Fly   265 IYFALGLTEKANTYYKMFITWTNQKIR-------KTFVHRNMFDFKHIKPFDKAY------IDNP 316
            |||...:.:.|.....:...|.::..:       :.:.|.|:.....:|.:|..|      ...|
 Worm   319 IYFISPVAKSAIAMASISAEWMSESRQNAVYLPEEPYSHSNLIKSGRVKIYDSLYGSFSKEFKTP 383

  Fly   317 GAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIM--PGYCVQGTVGNKILGGAKKVEFENRQVVE 379
              .|:||:...|..|.:..:.:....:..|.||:  |....:..          :..|.|..:..
 Worm   384 --CVIFASHASLRIGDAAHMVEVLGSDPKNAVIVTDPDLPCEDV----------REPFRNLPIKF 436

  Fly   380 VKMAVEY-MSFSAHADAKGIMQLIQNCEPKNVMLVHGEAGKMKFLRSKIKD---EFNLETYMPAN 440
            :.:.::: |.|::      :.:|:.:.:||.|:.      ...:.|..|:.   :.|.|...|..
 Worm   437 INIPMDFRMDFAS------LERLLADAKPKYVLC------SSSYTRPMIRRPDMQINYEKVWPIE 489

  Fly   441 GETCV------------ISTPV----------------KIPVDASVSLLKAEARSYNAQPPDPKR 477
            .:.||            ::..|                |:.|.:....|.|....:...|...|.
 Worm   490 YDECVQLSKLSRNKQKLVTVAVHPEVVKNLKFKQHPSKKLAVASIACHLSAYNDDFKLVPAKVKI 554

  Fly   478 RRLIHGVLVMKDNRIMLQNLTDALKE---------------IGINRHVMRFTSKVKMDDSGPVIR 527
            .|..:|       ||.|..:..||::               :.|:....:.|  ||.|.:|..|.
 Worm   555 ARRKYG-------RITLAKVLKALRDKNWDAKEVEKPDETVLEIDELEAKIT--VKNDGTGTKIS 610

  Fly   528 TS--ERLKTLLEEKLAGWTVTMQENGSIAIESVEVK 561
            ::  |..:.:||...   ::.::::|.:...:||:|
 Worm   611 SNNQENREKILEMIR---SILIEDDGLVGRNNVEIK 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS11	NP_651721.1	YSH1	5..416	CDD:440849	89/491 (18%)
		INTS11-like_MBL-fold	6..204	CDD:293849	47/258 (18%)
ints-9	NP_504953.1	metallo-hydrolase-like_MBL-fold	1..256	CDD:451500	46/256 (18%)
		Beta-Casp	298..416	CDD:214983	23/119 (19%)