DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr24 and WDR24

DIOPT Version :9

Sequence 1:	NP_733303.2	Gene:	Wdr24 / 43505	FlyBaseID:	FBgn0027518	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_011521001.1	Gene:	WDR24 / 84219	HGNCID:	20852	Length:	879	Species:	Homo sapiens

Alignment Length:	903	Identity:	313/903 - (34%)
Similarity:	446/903 - (49%)	Gaps:	190/903 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LEGHANALALNKDNNQIALAGRSLLKVYSINSNGFTESCNMR-GKNQNLSYSANDVAWSTLDSNL 80
            |:..|||:::.:|..|:.:||||:.|:|:|....|.|..|:| |:..:|:.|..||.|..:|.||
Human    25 LDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENL 89

  Fly    81 LATAATNGVVSVWDLSKFGRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRSDK 145
            ||||||||||..|:|.:..|.||..::.||:||.:.|.||.:|.::|:||||||.:||||:|...
Human    90 LATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKD 154

  Fly   146 SINTY----------------------------------------------------FC------ 152
            |::|:                                                    :|
Human   155 SVSTFSGPREWAMAGCVPILPVLSCRILRLHHSFAHGPMQDAESTANDAREYVLQITWCPAPGPR 219

  Fly   153 -------------------------------NSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRK 186
                                           .|||||||:||......|::..|||.|||||:|:
Human   220 LLWRLCVAASLGRSWGCPLYPLGLCSGPQAGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRR 284

  Fly   187 WDKCMVQFTAHYGPVYTCDWHP-TRNWLATGSRDKQIKVWNMDGRPGLE-HTIHTIAVVGRVKWR 249
            .|:|...||||.|||:.||||| .|.|||||.|||.:|||:|......| |.:.|||.|.|||||
Human   285 PDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWR 349

  Fly   250 PERTYHIASCALVVDYSVHVWDIRRPYIPFASFNEHTNVTTGIAWQ-GSDSHCLLSISKDSTIYK 313
            ||..:|:|:|:::||::::|||:|||::|.|.|.||.:|||||||: ..|...|||.||||::.:
Human   350 PECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQ 414

  Fly   314 HAFKDATRPALKANAQGASLGRFGDISFANKIKEYEPKTSGASNTKSSS-------FISRRKTNV 371
            |.|:||::|..:||.:|...|.|||::||.|    |...:..|..|..:       |..|:
Human   415 HLFRDASQPVERANPEGLCYGLFGDLAFAAK----ESLVAAESGRKPYTGDRRHPIFFKRK---- 471

  Fly   372 AGSIQFHLDHSKMYKFMVNDTFSGYPLSESVSRPTQEHES-------FIGCARELVISGKKLSEL 429
                   ||.::.:..:.:...|.:           |.|.       |:..|....::|:.|:||
Human   472 -------LDPAEPFAGLASSALSVF-----------ETEPGGGGMRWFVDTAERYALAGRPLAEL 518

  Fly   430 CEHNAEVSKKYGKHNATTLWNFIKLFYGSNHFEPPFEHRSSFSNQKN---P-MNSRRATQVASDW 490
            |:|||:|:::.|::.....|..:::.|.|....|......|.....:   | |||.....:|
Human   519 CDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLPLMNSFNLKDMA--- 580

  Fly   491 PQQRTELGQDLN-GNTPETAHEID-----VANVDDDTLGSSGVEHPPTSSVILSETQIISEITFD 549
            |...:|...|.: |:.......:|     :.|.|::....|.|    .:..:|.:.    |...|
Human   581 PGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDV----PADYLLGDV----EGEED 637

  Fly   550 NFELLRNGFIYVGPTEC--PKALAFPALHHDVQAARPQLDLKASDH--EKSPPPHVP-------- 602
            ...||.....:....||  |:. ||| |.|::....|     ..:|  :|:..|||.
Human   638 ELYLLDPEHAHPEDPECVLPQE-AFP-LRHEIVDTPP-----GPEHLQDKADSPHVSGSEADVAS 695

  Fly   603 --------TVLKVSHVPPIPMWEPHKF---VSDALMLMNDVGDVQTALTVLIALGE-ARKLLPID 655
                    ::|.|||........|..|   |.|.|....:.||||.|::|||.||| .||  .||
Human   696 LAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRK--DID 758

  Fly   656 DALVEHWFYTYVDQLHRYELWNEACEVINRSWLRSVQQLNQHSTAMHTNCGECGRPMGGKVGWYC 720
            :...|||:.:|:|.|.|:.|||.:.||:..|..|:|..|||.||.:|.||..|.|||..: ||.|
Human   759 EQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSR-GWVC 822

  Fly   721 DKCKSMQSAKCCVCGLIVRGVYAWCQGCSHGGHIEHLQKYFAKHSKCPK-CGHLCAYS 777
            |:|....| .|.||..:|:|::.||||||||||::|:.|:....|.||. |||||.||
Human   823 DRCHRCAS-MCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr24	NP_733303.2	WD40	13..311	CDD:238121	154/386 (40%)
		WD40	22..>312	CDD:225201	152/382 (40%)
		WD40 repeat	70..109	CDD:293791	21/38 (55%)
		WD40 repeat	115..152	CDD:293791	18/88 (20%)
		WD40 repeat	157..194	CDD:293791	18/36 (50%)
		WD40 repeat	202..236	CDD:293791	19/35 (54%)
		WD40 repeat	243..283	CDD:293791	21/39 (54%)
		Zn_ribbon_17	<720..777	CDD:305234	29/57 (51%)
WDR24	XP_011521001.1	WD40	40..412	CDD:225201	149/371 (40%)
		WD40 repeat	74..118	CDD:293791	22/43 (51%)
		WD40	86..412	CDD:295369	131/325 (40%)
		WD40 repeat	123..160	CDD:293791	18/36 (50%)
		WD40 repeat	177..245	CDD:293791	1/67 (1%)
		WD40 repeat	255..293	CDD:293791	18/37 (49%)
		WD40 repeat	299..341	CDD:293791	22/41 (54%)
		WD40 repeat	343..370	CDD:293791	13/26 (50%)
		WD40 repeat	389..413	CDD:293791	14/23 (61%)
		Zn_ribbon_17	831..876	CDD:305234	23/44 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159578
Domainoid	1	1.000	297	1.000	Domainoid score	I1471
eggNOG	1	0.900	-	-		E1_KOG0269
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6870
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1302
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56054
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	1	1.000	-	-		FOG0005790
OrthoInspector	1	1.000	-	-		oto89777
orthoMCL	1	0.900	-	-		OOG6_104440
Panther	1	1.100	-	-	LDO	PTHR46200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1781
SonicParanoid	1	1.000	-	-		X4181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800