DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr24 and WDR59

DIOPT Version :9

Sequence 1:	NP_733303.2	Gene:	Wdr24 / 43505	FlyBaseID:	FBgn0027518	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	XP_005256203.1	Gene:	WDR59 / 79726	HGNCID:	25706	Length:	993	Species:	Homo sapiens

Alignment Length:	1061	Identity:	197/1061 - (18%)
Similarity:	330/1061 - (31%)	Gaps:	393/1061 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EGHANALALNKDNNQIALAGRSLLKVYSINSNGFTESCNMRGKNQNLSYSANDVAWSTLDS--NL 80
            :..|.|::::.......|:||..|  |.:|.:...|  ..|..::...:....|.|:..||  :.
Human    16 DSQATAMSVDCLGQHAVLSGRRFL--YIVNLDAPFE--GHRKISRQSKWDIGAVQWNPHDSFAHY 76

  Fly    81 LATAATNGVVSVWDLSKF--GRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRS 143
            .|.::...|    ||.|:  |..:.......|.|....:.:...||::|::.|.|..|..:||:.
Human    77 FAASSNQRV----DLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD 137

  Fly   144 DKSINTYFCNSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRKWDKCMVQFTAHYGPVYTCDWHP 208
            .:..............||::....|.. |.|.:|.|::||.||....:....||...::..||||
Human   138 TRKPTVALSAVAGASQVKWNKKNANCL-ATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHP 201

  Fly   209 -TRNWLATGSRDKQIKVWNMDGRPGLEHTIHTIAVVGRVKWRPERTY-HIASCALVV-------- 263
             :.:.|||.|:|..:|.|:                     :|..|.| :|..|.:.|
Human   202 DSEHILATSSQDNSVKFWD---------------------YRQPRKYLNILPCQVPVWKARYTPF 245

  Fly   264 --------------DYSVHVWDIRRPYIPFASFNEHTNVTTGIAW----QGSDSHCLLSISKDST 310
                          :.|:.:|::.....|..:|..|.:|.....|    :||..:.|::.|:|.|
Human   246 SNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQT 310

  Fly   311 I--------------------------------------------YKHAFKDATRPALKAN---- 327
            :                                            ::|........|||.:
Human   311 LRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTASHGEEEALKEDPPRN 375

  Fly   328 ----AQGASLG-------RFGDISFANKIKEYEPKTSGASNTKS-----------SSFISRRKTN 370
                .:...||       .|..|:...:....|...:..|.|.|           ..|.::...|
Human   376 LLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVKFPAQYPNN 440

  Fly   371 VAGSIQF-------HLDHSKMYKFMVNDTFSGYPLSESVSRPTQEHESFIGCARELVISGKKLSE 428
            .|.|.||       ....:|:.|.:.:.........:|...|         |.|:||...:  |.
Human   441 AAPSFQFINPTTITSTMKAKLLKILKDTALQKVKRGQSCLEP---------CLRQLVSCLE--SF 494

  Fly   429 LCEHNAEVSKKYGKHNATT--LWNFIKL--FYGSN----------------------HFEPPFE- 466
            :.:.::..|..:...|:.|  |..|.::  .|||.                      :|..|..
Human   495 VNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTM 559

  Fly   467 HR-----------------------------------------------------SSF--SNQKN 476
            ||                                                     |||  ..:.:
Human   560 HRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERMS 624

  Fly   477 PMNSRR--ATQVASDWPQQR----TELGQDLNGN-------------------TPETAHEIDVAN 516
            |.::||  :.|..:|:|:.|    ...|.| :||                   ..::..|:.:.|
Human   625 PRSARRRWSIQAINDFPKSRRWKSKREGSD-SGNRQIKAAGKVIIQDIACLLPVHKSLGELYILN 688

  Fly   517 VDD--DTLGSSGVEHPPTSSVILSETQII-----SEITFDNFELLRNGFIYVGPTECPKALAFPA 574
            |:|  :|...:.     .|::::....::     :.:..|         :.:||...|. |..|.
Human   689 VNDIQETCQKNA-----ASALLVGRKDLVQVWSLATVATD---------LCLGPKSDPD-LETPW 738

  Fly   575 LHH------------------DVQA-----------ARPQLDLKASDHEKSPPPHVPTVLKVSHV 610
            ..|                  |||.           :|||    ...:...|.|:..:.|.|||
Human   739 ARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQ----GLPNPFGPFPNRSSNLVVSH- 798

  Fly   611 PPIPMWEPHKFVSDALMLMNDVGDVQT---------ALTVLIALGEA------------------ 648
                ...|....|.:...|:|.| :.|         |..:....||:
Human   799 ----SRYPSFTSSGSCSSMSDPG-LNTGGWNIAGREAEHLSSPWGESSPEELRFGSLTYSDPRER 858

  Fly   649 ---------RKLLPIDDALVEHWFYTYVDQLHRYELWNEACEVINRSWLRSVQQLNQHSTAMHTN 704
                     |.|.|.:....:.:...|.:.|:|:.|..:..||:.                 ..:
Human   859 ERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLK-----------------FVS 906

  Fly   705 CGECGRP----MGGKVGWYCDKCKS----MQSA-------KCCVCGLIVRGVYAWCQGCSHGGHI 754
            |     |    .|.:.|.||..|:|    .|.|       :|.:|.:.|||...:|..|.||||.
Human   907 C-----PPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHT 966

  Fly   755 EHLQKYFAKHSKCPK-CGHLC 774
            .|:.::|.....||. ||..|
Human   967 SHMMEWFRTQEVCPTGCGCHC 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr24	NP_733303.2	WD40	13..311	CDD:238121	72/324 (22%)
		WD40	22..>312	CDD:225201	72/365 (20%)
		WD40 repeat	70..109	CDD:293791	10/42 (24%)
		WD40 repeat	115..152	CDD:293791	8/36 (22%)
		WD40 repeat	157..194	CDD:293791	11/36 (31%)
		WD40 repeat	202..236	CDD:293791	11/34 (32%)
		WD40 repeat	243..283	CDD:293791	9/62 (15%)
		Zn_ribbon_17	<720..777	CDD:305234	23/67 (34%)
WDR59	XP_005256203.1	WD40	<34..328	CDD:225201	70/323 (22%)
		WD40 repeat	62..103	CDD:293791	10/44 (23%)
		WD40	100..>343	CDD:295369	53/264 (20%)
		WD40 repeat	109..150	CDD:293791	8/40 (20%)
		WD40 repeat	154..188	CDD:293791	11/34 (32%)
		WD40 repeat	195..229	CDD:293791	14/54 (26%)
		WD40 repeat	237..279	CDD:293791	4/41 (10%)
		WD40 repeat	285..316	CDD:293791	7/30 (23%)
		RWD	394..494	CDD:214735	20/110 (18%)
		Zn_ribbon_17	943..991	CDD:305234	18/45 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920