DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr24 and Wdr24

DIOPT Version :9

Sequence 1:	NP_733303.2	Gene:	Wdr24 / 43505	FlyBaseID:	FBgn0027518	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_001178013.1	Gene:	Wdr24 / 360497	RGDID:	1304803	Length:	790	Species:	Rattus norvegicus

Alignment Length:	817	Identity:	310/817 - (37%)
Similarity:	446/817 - (54%)	Gaps:	107/817 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LEGHANALALNKDNNQIALAGRSLLKVYSINSNGFTESCNMR-GKNQNLSYSANDVAWSTLDSNL 80
            |:..|||:::.:|..|:.:||||:.|:|:|....|.|..|:| |:..:|:.|..||.|..:|.||
  Rat    25 LDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENL 89

  Fly    81 LATAATNGVVSVWDLSKFGRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRSDK 145
            ||||||||||..|:|.:..|.||..::.||:||.:.|.||.:|.::|:||||||.:||||:|...
  Rat    90 LATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKD 154

  Fly   146 SINTYFCNSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRKWDKCMVQFTAHYGPVYTCDWHP-T 209
            |::|:...|||||||:||......|::..|||.|||||:|:.|:|...||||.|||:.||||| .
  Rat   155 SVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPED 219

  Fly   210 RNWLATGSRDKQIKVWNMDGRPGLE-HTIHTIAVVGRVKWRPERTYHIASCALVVDYSVHVWDIR 273
            |.|||||.|||.:|||:|......| |.:.|||.|.|||||||..:|:|:|:::||::::|||:|
  Rat   220 RGWLATGGRDKMVKVWDMTTHRAKEIHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVR 284

  Fly   274 RPYIPFASFNEHTNVTTGIAWQ-GSDSHCLLSISKDSTIYKHAFKDATRPALKANAQGASLGRFG 337
            ||::|.|.|.||.:|||||||: ..|...|||.|||||:.:|.|:||::|..:||.:|...|.||
  Rat   285 RPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFG 349

  Fly   338 DISFANKIKEYEPKTSG----ASNTKSSSFISRRKTNVAGSIQFHLDHSKMYKFMVNDTFSGYPL 398
            |::||.| :......||    |.:.:...|..|:           ||.::.:..:.:...|.:
  Rat   350 DLAFAVK-ESLVAAESGRKPYAGDRRHPIFFKRK-----------LDPAEPFSGLASSALSVF-- 400

  Fly   399 SESVSRPTQEHES-------FIGCARELVISGKKLSELCEHNAEVSKKYGKHNATTLWNFIKLFY 456
                     |.||       |:..|....::|:.|:|||:|||:|:::.|::.....|..:::.|
  Rat   401 ---------ETESGGGSMSWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIY 456

  Fly   457 GSNHFEPPFEHRSSFSNQKNP--------MNSRRATQVASDWPQQRTELGQDLN-GNTPETAHEI 512
            .|    |.....::.::....        |||.....:.   |...:|...|.: |:|......:
  Rat   457 CS----PGLVSSANLNHSVGKGSSCSLPLMNSFNLKDMG---PGLGSETRLDRSKGDTRSDTVLL 514

  Fly   513 D-----VANVD-DDTLGSSGVEHPPTSSVILSETQIISEITFDNFELLRNGFIYVGPTECPKAL- 570
            |     :.|.| ::|.||.           :....::.::..:..||......:|.|.|....|
  Rat   515 DSSATLITNEDNEETEGSD-----------VPADYLLGDVEGEEDELYPLDTEHVHPEEPEYVLP 568

  Fly   571 --AFPALHHDVQAARPQLDLKASDH--EKSPPPHV----------------PTVLKVSHVPPIPM 615
              |||..|..|...      ...:|  :|:..|||                .::|.|||......
  Rat   569 QEAFPLRHEIVDTP------SGPEHLQDKADSPHVSGNEADTASLAPVDSSSSLLSVSHALYDSR 627

  Fly   616 WEPHKF---VSDALMLMNDVGDVQTALTVLIALGE-ARKLLPIDDALVEHWFYTYVDQLHRYELW 676
            ..|..|   |.|.|....:.||||.|::|||.||| .||  .||:...|||:.:|:|.|.|:.||
  Rat   628 LPPDFFSVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRK--DIDEQTQEHWYTSYIDLLQRFCLW 690

  Fly   677 NEACEVINRSWLRSVQQLNQHSTAMHTNCGECGRPMGGKVGWYCDKCKSMQSAKCCVCGLIVRGV 741
            |.:.||:..|..|:|..|||.||.:|.||..|.|||..: ||.||:|:...| .|.||..:|:|:
  Rat   691 NVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSR-GWVCDRCRRCAS-MCAVCHHVVKGL 753

  Fly   742 YAWCQGCSHGGHIEHLQKYFAKHSKCPK-CGHLCAYS 777
            :.||||||||||::|:.|:....|.||. |||||.||
  Rat   754 FVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr24	NP_733303.2	WD40	13..311	CDD:238121	153/297 (52%)
		WD40	22..>312	CDD:225201	152/293 (52%)
		WD40 repeat	70..109	CDD:293791	21/38 (55%)
		WD40 repeat	115..152	CDD:293791	18/36 (50%)
		WD40 repeat	157..194	CDD:293791	18/36 (50%)
		WD40 repeat	202..236	CDD:293791	19/35 (54%)
		WD40 repeat	243..283	CDD:293791	21/39 (54%)
		Zn_ribbon_17	<720..777	CDD:305234	29/57 (51%)
Wdr24	NP_001178013.1	WD40 repeat	75..118	CDD:293791	22/42 (52%)
		WD40	<86..323	CDD:421866	130/239 (54%)
		WD40 repeat	124..161	CDD:293791	18/36 (50%)
		WD40 repeat	166..203	CDD:293791	17/36 (47%)
		WD40 repeat	211..247	CDD:293791	20/37 (54%)
		WD40 repeat	254..294	CDD:293791	21/39 (54%)
		mRING-H2-C3H3C2_WDR24	742..787	CDD:319607	25/45 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353628
Domainoid	1	1.000	304	1.000	Domainoid score	I1337
eggNOG	1	0.900	-	-		E1_KOG0269
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6870
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1218
OMA	1	1.010	-	-		QHG56054
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	1	1.000	-	-		FOG0005790
OrthoInspector	1	1.000	-	-		oto96892
orthoMCL	1	0.900	-	-		OOG6_104440
Panther	1	1.100	-	-	LDO	PTHR46200
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770