DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr24 and SPAC4F8.11

DIOPT Version :9

Sequence 1:	NP_733303.2	Gene:	Wdr24 / 43505	FlyBaseID:	FBgn0027518	Length:	777	Species:	Drosophila melanogaster
Sequence 2:	NP_593862.1	Gene:	SPAC4F8.11 / 2543518	PomBaseID:	SPAC4F8.11	Length:	846	Species:	Schizosaccharomyces pombe

Alignment Length:	863	Identity:	217/863 - (25%)
Similarity:	364/863 - (42%)	Gaps:	182/863 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NALALNKDNNQIALAGRSLLKVYSINSNGFTE----SCNMRGKNQNLSYSANDVAW-STLDSNLL 81
            :|:::||...::.:|||.||||.::|.|....    |..::...|....|.|||.| |:..|||:
pombe    43 SAISVNKSRTKVGVAGRELLKVLAVNPNSSKPPVCISDLLQKSTQTKHISCNDVKWGSSFASNLI 107

  Fly    82 ATAATNGVVSVWDLSKFGRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRSDKS 146
            .|.:..|.::|||::   .:..|..:|||.|..|.:...|..|:.:::.||||.||.:|.:...|
pombe   108 FTCSPLGNLNVWDVN---LEALLYDFNEHSRAVHKLDISSFHPSYVLTASQDGLIKLWDYKESSS 169

  Fly   147 INTYFCNSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRKWDKCMVQFTAHYGPVYTCDWHPTRN 211
            ..|:..|||:.|||.|||...|.|.|..::|.:|.||:|......::..||.|.|...::.|...
pombe   170 TITFRGNSEAARDVVFSPSEPNEFVAAYDSGILQKWDIRFPKLPFLKLAAHNGVVLCVNYSPNGV 234

  Fly   212 WLATGSRDKQIKVW-NMDGRPGLEHTIHTIAVVGRVKWRPER-----TYHIASCALVVDYSVHVW 270
            :||:..|||.|::| :...:.....||:.::.:..|:|||..     :..:||.:||.|.:::||
pombe   235 FLASCGRDKTIRIWDSTSNKKKSLITINNVSPLNCVRWRPANQQSRGSNQLASSSLVGDTAINVW 299

  Fly   271 DIRRPYIPFASFNEHTNVTTGIAWQGSDSHCLLSISKD----STIYKHAFKD-----------AT 320
            ||.|||||:.:.:.|.::.:.:.|  :.:..|.|.|||    .|..::||..           :|
pombe   300 DITRPYIPYRTVSCHDSIVSTMHW--ASTELLWSCSKDGIFSQTRVENAFNCIDMLPRATSSWST 362

  Fly   321 RPALKANAQGASLGRFGDISFANKIKEYEPKTSGASNTKSSSFISRRKTNVAGSIQFHLDHSKMY 385
            :.:|..::...|..|   :|..|::..:|   |..|:.||:.:.|:   |..||.      |...
pombe   363 KNSLVFSSNPISNQR---LSSLNRVASFE---SNISSLKSALYASQ---NSDGST------SNPV 412

  Fly   386 KFMVNDTFSGYP--------LSESVSRPTQEHESFIGCARELVISGKKLSELCEHNAEVSKKYGK 442
            .| |...|.|.|        .||.|::       |...|:...||| .:|..|:.||..::..|.
pombe   413 PF-VPHNFVGIPQELGILAYRSEDVAQ-------FCYLAKNYRISG-DISSACKENAFFARNVGA 468

  Fly   443 HNATTLWNFIKLFYG---------SNHFEPPF-EHRSSFSNQKNPMNSRRATQVASDWPQQRTEL 497
            ..|..:|:.:....|         |.....|| ...:|.::.:...|.:..||:::........|
pombe   469 EFAYQIWDALYFSLGVLNNSDKGISELINIPFVSANNSMADDEKGRNLKNLTQISTSSTPAHDNL 533

  Fly   498 G-----QDLNGNTPETAHEIDVA---NVDDDTLGSSGVEHPPTSSVILSETQI-ISEITFDNFEL 553
            .     :....:||..:....:.   |:|...|......|...:.::|.:.|. ::..:.|:...
pombe   534 SLNDFFEPREASTPSESSNSSIESEDNLDKAVLNKQSQWHDLENPIVLKKGQAPVNNFSTDSRAS 598

  Fly   554 LRNGFI-------YVGPTECPKALAFP--------------------------------ALHHDV 579
            :.:.::       |.|.:......:|.                                :||.|.
pombe   599 INSSYLLDSAASNYSGTSHNEMFNSFHRSSVTSASIKSREAVLSAGNSSRRASIFLDQLSLHGDT 663

  Fly   580 QAARPQLDLKASDHEKSPPPHVPTVLKVSHVPPIPMWEPHKFVSDALMLMNDVGDVQTALTVLIA 644
            .:..|..||        ||..:|.|:.             ..:||.:    ..||||||..|...
pombe   664 DSEIPIDDL--------PPIELPYVVT-------------SIISDCI----SRGDVQTAACVCSV 703

  Fly   645 LGEARKLLP---IDDALVEHWFYTYVDQLHRYELWNEACEVINRSWLRSVQQLN----------Q 696
            .......||   :||.|     .:|||.|.|:.:::||..:||.|..::::.::          :
pombe   704 FSYLTIDLPRIQLDDLL-----ESYVDLLRRFGMFSEATLLINMSGSKNLKYIHSSSRDLIFEME 763

  Fly   697 HSTAMHTNCGECGRPMGGKVGWYCDKCKSMQSAKCCV-CGLIVRGVYAWCQGCSHGGHIEHLQKY 760
            :..|......|.|:          :..|::.|.|.|| |.|.:|||..:...|.|.||...|:.:
pombe   764 NKKATGNEQSEKGK----------ENAKTVTSLKKCVYCELPLRGVLVYPPVCGHIGHESCLRSW 818

  Fly   761 FAKHSK-----C--PKCG 771
            :..::.     |  |.||
pombe   819 YFDNTDDALPVCPVPGCG 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr24	NP_733303.2	WD40	13..311	CDD:238121	101/303 (33%)
		WD40	22..>312	CDD:225201	102/304 (34%)
		WD40 repeat	70..109	CDD:293791	13/39 (33%)
		WD40 repeat	115..152	CDD:293791	12/36 (33%)
		WD40 repeat	157..194	CDD:293791	14/36 (39%)
		WD40 repeat	202..236	CDD:293791	8/34 (24%)
		WD40 repeat	243..283	CDD:293791	18/44 (41%)
		Zn_ribbon_17	<720..777	CDD:305234	19/60 (32%)
SPAC4F8.11	NP_593862.1	WD40	83..337	CDD:295369	88/258 (34%)
		WD40	<92..336	CDD:225201	86/248 (35%)
		WD40 repeat	138..175	CDD:293791	12/36 (33%)
		WD40 repeat	180..217	CDD:293791	14/36 (39%)
		WD40 repeat	225..260	CDD:293791	8/34 (24%)
		WD40 repeat	267..312	CDD:293791	18/44 (41%)
		Zn_ribbon_17	783..844	CDD:293725	18/54 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I2665
eggNOG	1	0.900	-	-		E1_KOG0269
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6870
Inparanoid	1	1.050	198	1.000	Inparanoid score	I1007
OMA	1	1.010	-	-		QHG56054
OrthoFinder	1	1.000	-	-		FOG0005790
OrthoInspector	1	1.000	-	-		oto101160
orthoMCL	1	0.900	-	-		OOG6_104440
Panther	1	1.100	-	-	LDO	PTHR46200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1781
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900