Protein Alignment Kul and ADAM9

DIOPT Version :10

• Sequence 1: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_003807.1
• Gene: ADAM9 / 8754
• HGNCID: 216
• Length: 819
• Species: Homo sapiens
• Alignment Length: 718
• Identity: 165/718 - (22%)
• Similarity: 242/718 - (33%)
• Gaps: 269/718 - (37%)

  Fly   381 NGTRELPSNFFNANWTTLF------LGNNNNGNDRPSHKTHVEIITKNGATKKPNIIVNNYNPEI 439
            :|.| .||......|..|.      ||....|..:.||.:..||||....|:           |.
Human     3 SGAR-FPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTR-----------ER 55

  Fly   440 IFAPNPHNPSFNSMMMTNLLSGRGGEDIHSSPR---LL--------YDRKTTCMLYLQADHTFFQ 493
            ..||.|:     |..::.::...|.|.|....|   ||        |:::.|    |..||...|
Human    56 REAPRPY-----SKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT----LITDHPNIQ 111

  Fly   494 KMGSDEASIEAITR---------------HVQRA--------------NTIYRNTDF-------- 521
            ........:|.:..               |::.|              :.|||..|.
Human   112 NHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCG 176

  Fly   522 ------------NNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGNYGVEKFLELFSEEDYD--- 571
                        :.:.:|.::|.:::|.:.      ..|..|:     ||.|: :..:|.||
Human   177 VSNKDIEKETAKDEEEEPPSMTQLLRRRRA------VLPQTRY-----VELFI-VVDKERYDMMG 229

  Fly   572 -------------AFCLAYMFTYRDFEMGTLGL-AWT-GDLKN-AGGVCEKNGHY---------- 610
                         |..|..|:...:..:..:|| .|| |:|.| .||..:..|::
Human   230 RNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLIT 294

  Fly   611 -----------------------------RGSLKSLNT-GIVTLLNYGKHVPPAVSHVTLAHEIG 645
                                         |.....:|. |.:|:..:...|         |||:|
Human   295 RRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIV---------AHELG 350

  Fly   646 HNFGSPHDP-EQCTPGGEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCFTEP 709
            ||.|..||. ..|:.|.:  :.||    .||...:.| ||:||.:..|.:...|..:......:|
Human   351 HNLGMNHDDGRDCSCGAK--SCIM----NSGASGSRN-FSSCSAEDFEKLTLNKGGNCLLNIPKP 408

  Fly   710 QSSI----CGNGVVEPGEQCDCGWEEDCK-DSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCT 769
            ..:.    |||.:|:.||:||||..::|: |.||         :.:.|.|...|.|  :.|.||
Human   409 DEAYSAPSCGNKLVDAGEECDCGTPKECELDPCC---------EGSTCKLKSFAEC--AYGDCC- 461

  Fly   770 TDCK-LKFGDKCRDDNG-CRDPSFCDGRVPQCPPSVNKPNKTIC-NKEFVCYMGDCTGSICLAYG 831
            .||: |..|..||.... |..|.:|:|....|.|.|...|...| |.:..||.|.|      .|.
Human   462 KDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMC------QYY 520

  Fly   832 LESCQCIPG------PQD---------DRIKSC--------------ELCCKLPGED-------- 859
            ...||.|.|      |:|         ||..:|              .||.||..|:
Human   521 DAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFG 585

  Fly   860 -------SPCRSSFEWN---EAPFDVPD--MYSKPGTPCN----------------DYNGYCDVF 896
                   :|.|.:..|.   :...||||  |.:: ||.|.                :|:  |||.
Human   586 IVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNE-GTKCGAGKICRNFQCVDASVLNYD--CDVQ 647

  Fly   897 QKC 899
            :||
Human   648 KKC 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	64/342 (19%)
		Disintegrin	720..801	CDD:459709	28/83 (34%)
ADAM9	NP_003807.1	Pep_M12B_propep	44..163	CDD:460254	25/138 (18%)
		ZnMc_adamalysin_II_like	212..404	CDD:239797	47/213 (22%)
		Disintegrin	423..496	CDD:459709	28/84 (33%)
		ACR	500..636	CDD:214743	33/142 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..763
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	780..819