DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Kul and Adam17

DIOPT Version :10

Sequence 1:NP_651716.1 Gene:Kul / 43501 FlyBaseID:FBgn0039688 Length:1537 Species:Drosophila melanogaster
Sequence 2:NP_064702.2 Gene:Adam17 / 57027 RGDID:620404 Length:827 Species:Rattus norvegicus


Alignment Length:660 Identity:184/660 - (27%)
Similarity:299/660 - (45%) Gaps:147/660 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 KTTCMLYLQADHTFFQKMGSDEASIEA--ITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVH 540
            |.||.|.:.|||.|::.||..|.|...  :...:.|.:.|||||.::|.|      |....:::.
  Rat   222 KNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAG------FKGYGVQIE 280

  Fly   541 NMNAMKDPSYRFPGN----------------YGVEKFLELFS---EEDYDAFCLAYMFTYRDFEM 586
            .:..:|.|....||.                :.|:..||.||   .|:....|||::|||:||:|
  Rat   281 QIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDM 345

  Fly   587 GTLGLAWTGD--LKNAGGVCEKNGHYRGSLKS---LNTGIVTLLNYGKHVPPAVSHVTLAHEIGH 646
            ||||||:.|.  ..:.||||.| .:|...:|.   ||:|:.:..||||.:....:.:...||:||
  Rat   346 GTLGLAYVGSPRANSHGGVCPK-AYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGH 409

  Fly   647 NFGSPHDPE---QCTPGGED--GNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCF 706
            |||:.|||:   :|.| .||  |.::|:..|.|||.:||..||.||.:||...:.:||:.   ||
  Rat   410 NFGAEHDPDGLAECAP-NEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQE---CF 470

  Fly   707 TEPQSSICGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTD 771
            .|..:.:|||..|:.||:||.|......|:||          .:.|||.|..:||....||| .:
  Rat   471 QERSNKVCGNSRVDEGEECDPGIMYLNNDTCC----------NSDCTLKPGVQCSDRNSPCC-KN 524

  Fly   772 CKLKFGD-KCRD--DNGCRDPSFCDGRVPQCPPSVNKPNKTICNKEFVCYMGDCTGSICLAY--- 830
            |:.:... ||::  :..|:..|:|.|...:|||..:..:.|:|     ..:|.|....|:.:   
  Rat   525 CQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVC-----LDLGKCKAGKCIPFCKR 584

  Fly   831 --GLESCQCIPGPQDDRIKSCELCCK-LPGEDSPCRSSFEWNEAPF---DVPDMYSKPGTPCNDY 889
              .||||.|.     |...||::||: |.|   ||        .|:   :..:::.:.|.||.  
  Rat   585 EQELESCACA-----DTDNSCKVCCRNLSG---PC--------VPYVDAEQKNLFLRKGKPCT-- 631

  Fly   890 NGYCDVFQKCREVDPSGPLATLRKLL------LSEESIASFKKWMQHNWYTVALAAVGVILLLAL 948
            .|:||:..||.:        .::.::      :.:.||.:|.|::..|       .||.:|:.:|
  Rat   632 VGFCDMNGKCEK--------RVQDVIERFWDFIDQLSINTFGKFLADN-------IVGSVLVFSL 681

  Fly   949 --------STKLLAKRSNLKLKSVTIIHSATTETVRLPENNNGVIVHTAVRTKVPFKKKVRGERT 1005
                    ....:.|:.:.:.:|:::.|.:..|.:...::       .:||...||      ...
  Rat   682 IFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDS-------ASVRIIKPF------PAP 733

  Fly  1006 KKPGTGAGVTAAAAVGTRNAAKSSANPEPK----------KTTRSQAMAKKKSFEEEPKKSSKKV 1060
            :.||....:..||.:...:||       ||          :...:.:......||::|..:|...
  Rat   734 QTPGRLQALQPAAMMPPVSAA-------PKLDHQRMDTIQEDPSTDSHVDDDGFEKDPFPNSSAA 791

  Fly  1061 GKHMKEIIDY 1070
            .|..:::.|:
  Rat   792 AKSFEDLTDH 801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KulNP_651716.1 Pep_M12B_propep 70..186 CDD:460254
ZnMc_TACE_like 479..713 CDD:239798 93/264 (35%)
Disintegrin 720..801 CDD:459709 25/83 (30%)
Adam17NP_064702.2 Pep_M12B_propep 52..167 CDD:460254
Cysteine switch. /evidence=ECO:0000250 182..189
ZnMc_TACE_like 223..477 CDD:239798 93/264 (35%)
DISIN 484..559 CDD:214490 27/85 (32%)
ADAM17_MPD 581..642 CDD:465239 22/78 (28%)
Crambin-like 603..671 19/88 (22%)
SH3-binding. /evidence=ECO:0000255 731..738 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..827 6/36 (17%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.