Protein Alignment Kul and Adam39

DIOPT Version :10

• Sequence 1: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001020551.3
• Gene: Adam39 / 546055
• MGIID: 3045694
• Length: 756
• Species: Mus musculus
• Alignment Length: 702
• Identity: 162/702 - (23%)
• Similarity: 228/702 - (32%)
• Gaps: 267/702 - (38%)

  Fly   352 YTKHKNIIVSTYNRPIEPEFGTPYEEPNNNGTRELPSNFFNANWTT--LFLGNNNNGNDRPSHKT 414
            |.:|.::          ||...|.....|.       ..:...|.|  |..|..       .|..
Mouse    49 YAQHTSL----------PEVVIPLRVTGNR-------PMWAMGWLTYSLHFGGQ-------KHFI 89

  Fly   415 HVE-------------IITKNGATKKPNIIVNN---Y------NPEIIFAPNPHNPSFNSMMMTN 457
            |::             ..||.||..|....|.|   |      :||.:.|.......|..::..|
Mouse    90 HIKAKKFLVSRLFSVFTYTKQGALHKDQPYVQNDCYYHGHMDGDPESMVAITTCYGGFQGILQIN 154

  Fly   458 LLSGRGGEDIHSSPRLLYDRKTTCMLYLQADHTF---FQKMGSDEASIE----AITRHVQRANTI 515
                  |......|:.|             ..||   ..||.|:|..:.    |:|..:.:...:
Mouse   155 ------GTVYEIKPKNL-------------SSTFEHLVHKMDSEETELYPMRCALTEEIAKQMKL 200

  Fly   516 YRNTDFNNDGKPDNITFM---------------------IKRIKVHNMNAMKDPSYRFPGNYGVE 559
            .:|         :|.|.|                     .:|:..||.|.         .:..||
Mouse   201 QQN---------ENPTLMQSHYEGWWTHRSFLDLALVVDCERVHYHNNNT---------SHVLVE 247

  Fly   560 KF---------------------LELFSEEDY----------DAFC--------------LAYMF 579
            .|                     :|:::|:::          ..||              :|::|
Mouse   248 VFTIVNIINNIYETLDVELVLLGVEMWNEKNHVQGRNINEFLVEFCDWKARSLNFRIPNDIAHIF 312

  Fly   580 TYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLN----YGKHVPPAVSHVTL 640
            ...||:: .||:|:      .||||         |.|.|.|:..||.    |..|:        :
Mouse   313 VNLDFQI-YLGVAY------VGGVC---------LPSYNCGVDCLLGGNLFYFGHI--------I 353

  Fly   641 AHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGC 705
            |||||||.|..||...||.|   .|..:.|.|.:|    .:|||.||..    ....|..:.| |
Mouse   354 AHEIGHNLGMEHDSSSCTCG---RNVCLMAPADNG----ISKFSNCSYS----YFWTKYPTAK-C 406

  Fly   706 FTEPQSSI-------CGNGVVEPGEQCDCGWEEDCKDS-CCFPMSRQPRLDETPCTLTPHARCSP 762
            ..:.:.||       ||:|||:.|||||||..::|.|. ||          :..|||...|.|
Mouse   407 MHKEKKSIGILRGKLCGDGVVDDGEQCDCGSAKNCADDPCC----------KRSCTLKDGAAC-- 459

  Fly   763 SQGPCCTTDCKLKFGDKCRD-DNGCRDPSFCDGRVPQCPPSVNKPNKTICNKEFVCYMGDCTG-- 824
            :.|.||.....::.|..||. ||.|..|.:|:|...:||..|...:.:.|.....||...|..
Mouse   460 AFGLCCKYCQIMEAGTVCRKRDNECDLPEWCNGHSHKCPNDVYLLDGSPCRDGGYCYEKRCNNRD 524

  Fly   825 SIC-LAYGLE------SCQCIPGPQDDRIKSC------ELCCKLPGEDSPC-------------- 862
            ..| ..:|.|      ||......|.||..:|      .|.|..|  |..|
Mouse   525 KQCKQIFGKEARSADHSCYRELNTQGDRFGNCGMIRDAYLRCHDP--DILCGRVQCENVTRIPFL 587

  Fly   863 --RSSFEWNEA------------PFDVPDM-YSKPGTPCNDYNGYCDVFQKC 899
              .|:..|...            ...:||: ..|.||.|...: .| :.:||
Mouse   588 RDHSTVHWTHLNGVTCWGTDYHFGMTIPDIGIVKDGTDCGPEH-VC-INKKC 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	67/310 (22%)
		Disintegrin	720..801	CDD:459709	29/82 (35%)
Adam39	NP_001020551.3	Pep_M12B_propep	57..173	CDD:460254	27/148 (18%)
		ZnMc_adamalysin_II_like	222..408	CDD:239797	55/230 (24%)
		Disintegrin	428..500	CDD:459709	30/83 (36%)
		ACR	504..640	CDD:214743	29/138 (21%)