Protein Alignment Kul and Adam5

DIOPT Version :10

• Sequence 1: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001423543.1
• Gene: Adam5 / 498654
• RGDID: 621471
• Length: 773
• Species: Rattus norvegicus
• Alignment Length: 537
• Identity: 118/537 - (21%)
• Similarity: 185/537 - (34%)
• Gaps: 181/537 - (33%)

  Fly   471 PRLLYDRKTTCMLYLQADHTFFQKMGSD-EASIEAITRHVQRANTIYRNTDFNNDGKPDNITFMI 534
            ||.:   ||..::    |...|..|||| ...::.:.:.:...||::...         .:|.:|
  Rat   184 PRYI---KTDIVV----DKKLFDYMGSDTRVVLQKVIQIIGFINTMFSKL---------KLTVLI 232

  Fly   535 KRIKVHNMNAMKDPSYRFPGNYGVEKFLELFS--EEDYDAFCLAYMFTYRDFEMGTLGLAWTGDL 597
            ..:::.:    |:....||  ...|..|..|.  :..|....::|:..:.:....| |..:.|:|
  Rat   233 NSVEIWS----KENRIDFP--EAPENLLVQFLHWKHKYRPQHISYLLAFVEHPAST-GALYPGNL 290

  Fly   598 KNAGGVCEK-NG-----HYRG-SLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPE 655
                  |:. .|     :.:| ||:|.:..::.||:.|         :.|.::   |..|.|
  Rat   291 ------CKPIYGAAIALYPKGLSLESYSVIVLQLLSIG---------IGLTYD---NADSCH--- 334

  Fly   656 QCTPGGEDGNF-IMFARAT-SGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCFTEPQSS------ 712
             ||     |:. :|..:|. ||..|:   ||||||...:.:.......::....|.|..
  Rat   335 -CT-----GDVCLMTPKAIYSGGVKD---FSTCSLDDFKYLSTQDLECLQDLPMERQKKKPSRPR 390

  Fly   713 -ICGNGVVEPGEQCDCGWEEDC-KDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLK 775
             |||||::|..||||||..::| ...||.|||         |.|...|.|  ..|.||..|||:|
  Rat   391 RICGNGILEMNEQCDCGTLKNCTHKKCCDPMS---------CRLKSKAVC--GSGECCGQDCKVK 444

  Fly   776 -FGDKCR-DDNGCRDPSFCDGRVPQCPPSVNKPNKTICNK-EFVCYMGDCTGSICLAYGLESCQC 837
             ....|| ..|.|....:|:|....|.|.....|...|:. :..||.|.|..|        :.||
  Rat   445 PVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTS--------NNQC 501

  Fly   838 IP-----------------GPQDDRIKSC------------------------------------ 849
            :.                 ..::||..:|
  Rat   502 MNLLGKYVRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKRLLMKDNMSAAYGQ 566

  Fly   850 ---ELCCKLPGEDSPCRSSFEWNEAPFDVPDMYSKPGT--------------------------- 884
               :||..|.....|.:::........:..:.:.|.||
  Rat   567 IRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMFCLETQCKETRFLVDFQQCNT 631

  Fly   885 --PCNDYNGYCDVFQKC 899
              .|||: |.|:.|..|
  Rat   632 SRDCNDH-GVCNNFNHC 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	52/252 (21%)
		Disintegrin	720..801	CDD:459709	31/83 (37%)
Adam5	NP_001423543.1	Pep_M12B_propep	26..142	CDD:460254
		Reprolysin	185..378	CDD:426256	52/245 (21%)
		Disintegrin	399..473	CDD:459709	31/84 (37%)
		ACR	477..620	CDD:214743	19/150 (13%)