Protein Alignment Kul and Adam26b

DIOPT Version :10

• Sequence 1: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001009547.1
• Gene: Adam26b / 382007
• MGIID: 3588304
• Length: 699
• Species: Mus musculus
• Alignment Length: 724
• Identity: 171/724 - (23%)
• Similarity: 261/724 - (36%)
• Gaps: 272/724 - (37%)

  Fly   315 GSRSYSS--------------GNNNAN---SNSNNNNSNNN------NNNNNSNNNVRKLYTKHK 356
            |...|||              |||.:.   |.|.|.....:      ..|..|.|.:...||:..
Mouse    20 GHAKYSSLPEVVTPLRVTVTRGNNTSPGWLSYSLNIGGQRHIITMKPKKNLMSRNLILLTYTQQG 84

  Fly   357 NIIVSTYNRPIEPE----FGTPYEEPNN-----------NGTRELPSNFFNANWTTLFLGNNNNG 406
            :::   ..||..|.    .|...|:|.:           .||.|:                  ||
Mouse    85 DLL---EQRPFVPNDCYYHGYVDEDPESLVILNTCFGSLQGTLEI------------------NG 128

  Fly   407 NDRPSHKTHVEIITKNGATKKPNII--VNNYNPEIIFAPNPHNPSFNSMMMTNLLSGRGGEDIHS 469
                   |..||:.|:..:...::.  ::|.:.|    |:|            :..|...|:| :
Mouse   129 -------TTYEIMPKSSTSTFEHLAYKMDNGDSE----PSP------------MRCGLSEEEI-A 169

  Fly   470 SPRLLYDRKTTCMLYLQAD-----HTFFQKMGSDEASIEAITRHVQRANTIYRNTDFNNDGKPDN 529
            ..|.|.:|....:|.:..:     |.|.:..        .:..|.|   .::||         :|
Mouse   170 QQRKLRERNAPTLLQIPHENWWTHHRFIEYF--------VVIDHKQ---YVHRN---------NN 214

  Fly   530 ITFMIKRIK--VHNMNAMKDPSYRFPGNY------GVEKFLELFSEEDY-----------DAFCL 575
            ||..|:.:.  |:.:|          |.|      .|...||:::|::|           ..||
Mouse   215 ITTCIQDMLQIVNGVN----------GYYLQIDTDVVLTALEIWNEKNYINVELSIFKVLGDFC- 268

  Fly   576 AYMFTYRDFEMGT------------------LGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIV 622
                |::....|.                  ||||:..|      ||          ...|.|:.
Mouse   269 ----TWKQNMFGNRIRHDIIHLLVRQGYGLYLGLAYLAD------VC----------TPYNCGVS 313

  Fly   623 TLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDKKNNNKFSTCS 687
            :.|:   .|...::|: :|||:|||.|..||...||.|.:|.....:       |.|:.|||.||
Mouse   314 SFLS---DVMSDMAHI-VAHEMGHNLGMKHDGIGCTCGLKDCLMAPY-------KTNSPKFSNCS 367

  Fly   688 LKSIEPVLNAKARSMKGCFTE-PQS-----SICGNGVVEPGEQCDCGWEEDC-KDSCCFPMSRQP 745
            .:.:..|:     :.:.|..: |::     ::|||.|||.||:||||..|.| :|.||
Mouse   368 YEEMYSVV-----TKRSCLYDIPEALVTNLTVCGNKVVEEGEECDCGSTESCLQDPCC------- 420

  Fly   746 RLDETPCTLTPHARCSPSQGPCCTTDCK-LKFGDKCRDD-NGCRDPSFCDGRVPQCPPSVNKPNK 808
               .:.|.|.|.|:|  :.|.|| .||: ||.|..||:: |.|..|.:|:|...:||..|.|.:.
Mouse   421 ---SSDCVLKPGAQC--AFGLCC-QDCQFLKTGTVCREEKNECDLPEWCNGTSAECPGDVYKADG 479

  Fly   809 TICNKEFVCYMGDC------------TGS-----ICL--------AYGLESCQCIPGPQDDRIKS 848
            ..|:.|..||..:|            .||     ||.        .:|  :|    |....:.|.
Mouse   480 IPCSGEGYCYKMECHQRDEQCRKIFGNGSRSADEICYMEMNRRGDRFG--NC----GNDSSKYKI 538

  Fly   849 CE----LCCKLPGED---SPCRSSFE------------WN---EAPFDVPDMYS-KPGTPCNDYN 890
            ||    ||.::..|:   .|.|.:.|            |.   .....:.|:.: ..||.|..|:
Mouse   539 CELADVLCGRIQCENVIQLPQRRNHETVHYTHFSNVTCWTMDYHFGITIDDIGAVSDGTACAPYH 603

  Fly   891 GYCDVFQKC 899
             .| |.:||
Mouse   604 -IC-VDRKC 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	59/281 (21%)
		Disintegrin	720..801	CDD:459709	33/83 (40%)
Adam26b	NP_001009547.1	Pep_M12B_propep	29..147	CDD:460254	26/145 (18%)
		ZnMc_adamalysin_II_like	195..383	CDD:239797	56/254 (22%)
		Disintegrin	401..473	CDD:459709	34/84 (40%)
		ACR	477..613	CDD:214743	31/142 (22%)