Protein Alignment Kul and kuz

DIOPT Version :9

• Sequence 1: NP_001287589.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Alignment Length: 1485
• Identity: 409/1485 - (27%)
• Similarity: 607/1485 - (40%)
• Gaps: 407/1485 - (27%)

  Fly    39 RLTPYIKHWEAANFDRQVLQAAQVRHLEQARFRQKREVTPSASGLAHTIRLNFSAHDRDFRLVLR 103
            ||..||.|:|..|:|.:        |:..:..|.:|.||..     ..:.|.|::|.|||.|.|:
  Fly    36 RLNEYISHYETLNYDHE--------HIRASHNRARRSVTKD-----QYVHLKFASHGRDFHLRLK 87

  Fly   104 QQPHSVFAHDVEIENTLGPIDYDVSRIYTGSLEDDEAAHVQAILTSDNLLDGTIETQAEHYYIEP 168
            :..:: |::.::..::.||||.....||.|.:..|..::|...: .:.:.:|.|.|:.:.||:|.
  Fly    88 RDLNT-FSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSI-HNGVFEGKIITERDAYYVEH 150

  Fly   169 AHRYSQQLAESGVHSIVYKLSDVNMQKQQFTGGGLNSATPAKTHCASEKLRKKRWLPEELAMSDA 233
            |..|                         |......:.||                |.....|.|
  Fly   151 AKHY-------------------------FPTNRTATTTP----------------PSTSTTSSA 174

  Fly   234 PAPTYNRNPPLPLDLEVPYNDDFRVLASEEDKSEESPRKY-PTTSTTRSTVRSTESFLATLT--K 295
            ...|.:..|..||   ...|.....:.|   |:|...:|. .:|:|::.....|||..::.|  .
  Fly   175 TTATKSTQPTRPL---AKSNTSTTAVNS---KTENFIKKIAESTTTSQQLPEYTESSSSSTTTFP 233

  Fly   296 PTS-------NRN---------ILVNNYNPSNLGEGSRSYSSGNNNANSNSNNNNSNNNNNNNNS 344
            ||:       .||         |:   |..|::.:...:...| :.|.....:..|....|..||
  Fly   234 PTTEYFEDEKERNAEDELDFHSII---YKESHVEDAYENVREG-HVAGCGITDEVSQWMENIQNS 294

  Fly   345 ---------NNNVRKLYTK--HKNIIVSTYNRPIEPE----FGTPYEEPNNNGTRELPSNF---- 390
                     :.:.:||:.|  ||........:|..|:    ....::.|:...|:|  :||
  Fly   295 AVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKE--ANFAEGA 357

  Fly   391 FNANWTTLFLGNNNNGND--RPSHKTHVEIITKNGATKKPNIIVNNYNPEIIFAPNPHNPSFNSM 453
            |....|...||::.|..|  :..|: .|...|.|||..:.
  Fly   358 FYDPSTGRRLGSSANVADWHQLVHE-RVRRATDNGAGDRG------------------------- 396

  Fly   454 MMTNLLSGRGGEDIHSSPRLLYDRKTTCMLYLQ-------------ADHTFFQKMGSDEASIEAI 505
              ::..||||.|          |.|.||.||:|             |||...:|...||.:.|.|
  Fly   397 --SSGGSGRGRE----------DNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEI 449

  Fly   506 T----RHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGN------YGVEK 560
            |    .||...|.|||||.|:...:..||.|.::|||:.:.:|.:: ||..|.|      ..|..
  Fly   450 TSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRN-SYNGPHNAFCNEHMDVSN 513

  Fly   561 FLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNA-GGVCEK--------NGHYRGSLKS 616
            ||.|.|.||:..|||||:||||||..|||||||......| ||:|||        .|.|:.:.:|
  Fly   514 FLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRS 578

  Fly   617 LNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHD-PEQCTPGGEDGNFIMFARATSGDKKNN 680
            |||||:|.:||...|||.||.:||||||||||||||| |::|.|||.:||:||||.|||||:.||
  Fly   579 LNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNN 643

  Fly   681 NKFSTCSLKSIEPVLNAKARSMK-GCFTEPQSSICGNGVVEPGEQCDCGW-EEDCKDSCCFPMSR 743
            :|||.||:::|..||:....:.| .||...:.:.|||.:||.||:||||: ||:|||.||:
  Fly   644 SKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCY---- 704

  Fly   744 QPRL----DET------PCTLTPHARCSPSQGPCC-TTDCKL---KFGDKCRDDNGCRDPSFCDG 794
             |||    |::      .||.....:||||||||| :..|..   .:..||:::..|...|.|:|
  Fly   705 -PRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNG 768

  Fly   795 RVPQCPPSVNKPNKTICNK-EFVCYMGDCTGSICLAYGLESC--QCIPGPQDDRIKSCELCCKLP 856
            ...:||...::.:||:||. ..:|..|:|:||.||.:.:..|  .....|...:.|.|:|.|:..
  Fly   769 TTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDG 833

  Fly   857 GEDSPCRSSFEWNEAPFDVPDMYS--------KPGTPCNDYNGYCDVFQKCREVDPSGPLATLRK 913
            .:.|.|||:.|:       .|.|:        :||:||:::.||||||.|||.||..|||..|:.
  Fly   834 NDTSTCRSTSEF-------ADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKN 891

  Fly   914 LLLSEESIASFKKWMQHNWYTVALAAVGVILLLALSTKLLA---KRSNLKLKSVTIIHSATTETV 975
            |||:.:::.:..:|:..|||.|.|..|..|:::....|..|   ..||.|.:....|    :||:
  Fly   892 LLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRI----SETL 952

  Fly   976 RLPENNNGVIVHTAVRTKVPFKKKVRGERTKKP-------------GTGAGVTAAAAVGTRNAAK 1027
            |.|.|       |..|.:....::..|.|:..|             |.|.|   ....|....::
  Fly   953 RAPMN-------TLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGG---GGGGGRHGGSR 1007

  Fly  1028 SSANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGKHMKEII------DYSNRNNNGDDASNLSTT 1086
            |.....|....|.|                   |.|  .|:      .:|:||:..:.|......
  Fly  1008 SHHQQHPHDWDRHQ-------------------GGH--SIVPLPTGGSHSSRNSAANQARRSDGR 1051

  Fly  1087 NNHTNTFGKVQKWLLESPIVAQPLSHIEHSSRVRKVMSKSQSTPERLVQKTPQKTKSMGNLSNEK 1151
            ...:.:.|:.|       .:|........::|........|:.|              |:
  Fly  1052 GPRSTSSGRPQ-------AIASGSGAASGAARSHGGYGAEQAIP--------------GS----- 1090

  Fly  1152 VKLQVVYKPPFKFSLRLSKKPKVKTHVVGAGVRPKRSQKTSNRTGGQSSSKEVSTRAKRSALLLC 1216
                                       :|.||:...|      :||      |..||:
  Fly  1091 ---------------------------IGGGVQAAIS------SGG------VVARAQ------- 1109

  Fly  1217 NEAEDDNQILTLNEPNYETLKPPTPPRSMEHCYENVDMQAEASSSKPSSSSKVAPSSQNRASLEV 1281
                               |..|.||.:.:   :.:..|.:....:|:    ::|..|.:.:. .
  Fly  1110 -------------------LPLPLPPPNGQ---QQMQQQQQLQLQQPA----ISPQQQPQQAF-Y 1147

  Fly  1282 TPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTRNFGSTQNLINLSQNLSKNKKRSS 1346
            ||.....||..|.|.:.:|.|........:::..||||:
  Fly  1148 TPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSGSVS-------------------------- 1186

  Fly  1347 LNLKASGSGATRSGKDPPTMGVASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNS 1401
                ..||||..|.|.  ..|.::..:.|.|..:.:.::|.||||...|.|.|.:
  Fly  1187 ----GPGSGAGSSSKS--KSGKSAKAKDSKSQKSQQANNSRSSSKEKGVKPVRRN 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_001287589.1	Pep_M12B_propep	72..174	CDD:279848	29/101 (29%)
		ZnMc_TACE_like	479..713	CDD:239798	125/267 (47%)
		Reprolysin_2	502..696	CDD:290307	110/213 (52%)
		Disintegrin	720..803	CDD:278623	38/97 (39%)
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	125/267 (47%)
		Reprolysin_2	450..659	CDD:290307	108/209 (52%)
		Disintegrin	684..776	CDD:278623	38/96 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4570
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14962at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45702
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3482
	5	4.970