Protein Alignment Kul and Adam19

DIOPT Version :10

• Sequence 1: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001153700.1
• Gene: Adam19 / 303068
• RGDID: 1585017
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 1151
• Identity: 250/1151 - (21%)
• Similarity: 376/1151 - (32%)
• Gaps: 390/1151 - (33%)

  Fly   241 NPPLPLDLEVPYNDDFRVLASEEDKSEESPR--KYPTTSTTRSTVRSTESFLATLTKPTSNRNIL 303
            :|||..:|.:|           :.::.||||  |:|.|:..|......|..| .|.|   |.::.
  Rat    39 SPPLQHELIIP-----------QWRTSESPRGGKHPLTAELRVMAEGRELIL-DLEK---NEHLF 88

  Fly   304 VNNYNPSNLGEGSRSY-SSGNNNANSNSNNNNS---------NNNNNNNNSNNNVRKLYTKHKNI 358
            ...|..:       .| :|||....:..:.::.         :.::...::...:|.|.     |
  Rat    89 APAYTET-------CYTASGNPQTTTLKSEDHCFYHGTVRKVDESSVTLSTCRGIRGLI-----I 141

  Fly   359 IVSTYNRPIEPEFGTPYEEPNNNGTRELPSNFFNANWTTLFLGNNNNGNDRPSHK------THVE 417
            :.|..:..|||       .||::....:    :.:....|..||....:.||:.|      ||
  Rat   142 VRSNLSYIIEP-------VPNSDNQHRI----YRSEHLKLPPGNCGFEHSRPTSKDWTLQFTH-- 193

  Fly   418 IITKNGATKKPNIIVNNYNPEIIFAPNPHNPSFNSMMMTNLLSGRGGEDIHSSPRLLYDRKTTCM 482
                  .|||                .|....              .||:||...:        .
  Rat   194 ------QTKK----------------QPRRMK--------------REDLHSMKYV--------E 214

  Fly   483 LYLQADHTFFQKMGSDEASIEAITRH--VQRANTI---YRNTDFNNDGKPDNITFMIKRIKVH-- 540
            |||.||:..|||...|:.:    |:|  ::.||.:   ||:...       .|..:...:..|
  Rat   215 LYLVADYAEFQKNRHDQDA----TKHKLMEIANYVDKFYRSLSI-------RIALVGLEVWTHGD 268

  Fly   541 NMNAMKDP--------SYRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLA---WT 594
            .....::|        |:|          .:|.:::.:|.   |.:.|.|.|:..|:|||   ..
  Rat   269 KCEVSENPYSTLWSFLSWR----------RKLLTQKSHDN---AQLITGRSFQGTTIGLAPLMAM 320

  Fly   595 GDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQ-CT 658
            ..:..:|||  ...|...::     |:.:               |:|||||||||..||... |:
  Rat   321 CSVYQSGGV--SMDHSENAI-----GVAS---------------TVAHEIGHNFGMSHDSAHCCS 363

  Fly   659 PGGEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNA----------KARSMKGCFTEPQSSI 713
            ....||..||.|.......|   .||:|:.|.::..|.:          ..|::.|      ...
  Rat   364 TSAADGGCIMAAATGHPFPK---VFSSCNRKELDRYLQSGGGMCLSNMPDTRTLYG------GRR 419

  Fly   714 CGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKF-G 777
            ||||.:|.||:||||.|::||:.||         :.:.|||...|.|  :.|.|| ..|||.. |
  Rat   420 CGNGYLEDGEECDCGEEDECKNPCC---------NASNCTLKEGAEC--AHGSCC-HQCKLVAPG 472

  Fly   778 DKCRDD-NGCRDPSFCDGRVPQCPPSVNKPNKTIC-NKEFVCYMGDCTGSICLAYGLESCQCIPG 840
            .:||:. ..|..|.||.|:.|.||.:..:.:.|.| ..:..||.|     :||.| .|.||.:.|
  Rat   473 TQCREQVRQCDLPEFCTGKSPHCPTNYYQMDGTPCEGGQAYCYNG-----MCLTY-QEQCQQLWG 531

  Fly   841 PQDDRIKSCELCCKLPGEDSPCRSSFEWNEAPFDVPDMYSKPGTPCNDYNGYCDVFQKCREVDPS 905
            |  ....:.:||             ||...|   ..|.|...|      .|....::||...|
  Rat   532 P--GARPALDLC-------------FERVNA---AGDTYGNCG------KGLNGKYRKCSPRD-- 570

  Fly   906 GPLATLRKLLLSEESIASFKKWMQHNWYTVALAAVGVILLLALSTKLLAKRSNLKLKSVTI---- 966
                                            |..|.|  ...||:.....||......||
  Rat   571 --------------------------------AKCGKI--QCQSTQARPLESNAVSIDTTITLNG 601

  Fly   967 --IHSATTETVRLPENNNGVIVHTAVRTKVPFKKKVRGERTKKPGTGAGVTAAAAVGTRNAAKSS 1029
              ||...|...|.||...|                 .|:.. .||.   |......|..:..
  Rat   602 RRIHCRGTHVYRGPEEEEG-----------------EGDML-DPGL---VMTGTKCGHNHIC--- 642

  Fly  1030 ANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGKHMKEIIDYSNRN------------NNGDDASN 1082
                      .:...:..|| .|.:...||...|.   :..:|:|            |...|..:
  Rat   643 ----------FEGQCRNTSF-FETEGCGKKCNGHG---VCNNNKNCHCFPGWAPPFCNTPGDGGS 693

  Fly  1083 LSTTNNHTNTFGKVQKWLLESPIVAQPLSHIEHSSRVRKVMSKSQSTPERLVQK--TPQKTKSMG 1145
            :.:......:.|.|...:..:..|...|..:.|..|....:.|..:.|.:|.|:  .|.:....|
  Rat   694 IDSGPLPPKSAGPVIAGVFSALFVLAVLVLLCHCYRQSHKLGKPSALPFKLRQQFSCPFRVSQNG 758

  Fly  1146 NL--SNEKVKLQ-------VVYKPPFKFSLRLSKKP---------KVKTHVVGAGVRPKRSQKTS 1192
            ..  :|...|||       |...|.   :||....|         :|::|.........|:..:|
  Rat   759 GTGHANPTFKLQTPQGKRKVTNTPE---TLRKPSHPPPRPPPDYLRVESHPAPLPAHLNRAAGSS 820

  Fly  1193 NRTGGQSSSKEVSTRAKRSALLLCNEAEDDNQILTLNEPNYETLKPPTPPRSMEHCYENVDMQAE 1257
            ...|.|...||.:.|...|..:                       ||.|     :|..:.|.
  Rat   821 PEAGAQIERKESARRPPPSRPM-----------------------PPAP-----NCLLSQDF--- 854

  Fly  1258 ASSSKPSSSSKVAPSSQNRASLEVTPPVTAQRNSYRRSNSLSTHNP 1303
               |:|....|..|::          ||..||...|...:...|.|
  Rat   855 ---SRPRPPQKALPAN----------PVPGQRTVPRPGGTSLFHPP 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	61/262 (23%)
		Disintegrin	720..801	CDD:459709	33/82 (40%)
Adam19	NP_001153700.1	Pep_M12B_propep	45..163	CDD:460254	29/155 (19%)
		Reprolysin	211..409	CDD:426256	59/254 (23%)
		DISIN	440..500	CDD:214490	25/71 (35%)
		ACR	502..650	CDD:214743	46/247 (19%)