Protein Alignment Kul and Adam23

DIOPT Version :10

• Sequence 1: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001025070.3
• Gene: Adam23 / 301460
• RGDID: 1305739
• Length: 828
• Species: Rattus norvegicus
• Alignment Length: 792
• Identity: 170/792 - (21%)
• Similarity: 270/792 - (34%)
• Gaps: 243/792 - (30%)

  Fly   215 SEKLRKKRWLPEELAMSDAPAPTYNRNPPLPLDLEVPYNDDFRVLASEEDKSEESPRKYPTTSTT 279
            |..::|:..||..|        .|..|.    |.|.||:    ||.::....::..:.......:
  Rat   100 SSAVQKEITLPSRL--------VYYINQ----DSESPYH----VLDTKARHQQKHNKAVHLAQAS 148

  Fly   280 RSTVRSTESFLATLTKPTSNRNILVNNYNPSNLGEGSRSYSSGNNNANSNSNNNNSNNNNNNNNS 344
            .........|:..|   ..|..:|.::|...:..:|.:.||.|..:...:.:.....::....::
  Rat   149 FQIEAFGSKFILDL---ILNNGLLSSDYVEIHYEDGKQMYSKGGEHCYYHGSIRGVKDSRVALST 210

  Fly   345 NNNVRKLYTKHKNIIVSTYNRPIEPEFGTPYEEPNNNGTRELPSNFFNANWTTLFLGNNNNGNDR 409
            .|.:..::..      .|:...|||                            |.|.::.....|
  Rat   211 CNGLHGMFED------DTFVYMIEP----------------------------LELTHDEKSTGR 241

  Fly   410 P---------SHKTHVEIITKNGATKKPNIIVNNYNPEIIF------APNPHNPSFNSMMMTNLL 459
            |         .:...::.::.:|:.:.|.:      ||:.:      |.||....|..|....|:
  Rat   242 PHIIQKTLAGQYSKQMKNLSTDGSDQWPLL------PELQWLRRRKRAVNPSRGVFEEMKYLELM 300

  Fly   460 SGRGGEDIHSSPRLLYDRKTTCMLYLQADHTFFQKMGSDEASIEAITRH-VQRANTIYR---NT- 519
                                     :..||..::|..|..|......:. |...::||:   ||
  Rat   301 -------------------------IVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTR 340

  Fly   520 ----DFNNDGKPDNITFMIKRIK-VHNMNAMKDPSYRFPGNYGVEKFLELFSEEDYDAFCLAYMF 579
                ......:.|.|...|..:: :|..:     .||       ::.     ::..||..|....
  Rat   341 VVLVAVETWTEKDQIDITINPVQMLHEFS-----KYR-------QRI-----KQHADAVHLISRV 388

  Fly   580 TYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEI 644
            |:. ::..:|..        .||||.:   .:|         |.:..||  :|.||:.| |:..:
  Rat   389 TFH-YKRSSLSY--------FGGVCSR---VKG---------VGVNEYG--LPMAVAQV-LSQSL 429

  Fly   645 GHNFGSPHDPEQCTPGGED----GNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGC 705
            ..|.|...:|....|..|.    |..||.....|    ::.|||.||:......|.   |....|
  Rat   430 AQNLGIQWEPSSRKPKCECIESWGGCIMEETGVS----HSRKFSKCSILEYRDFLQ---RGGGAC 487

  Fly   706 -FTEP----QSSICGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQG 765
             |..|    :.:.||||.||.||:||||:..:|...||           ..|:|:..|.|  |.|
  Rat   488 LFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGVCC-----------KKCSLSNGAHC--SDG 539

  Fly   766 PCC-TTDCKLKF-GDKCRDD-NGCRDPSFCDGRVPQCPPSVNKPNKTICNK-EFVCYMGDC---- 822
            ||| .|.|..:. |.:|||. |.|....:|.|...||||:::|.:...||: :..||.|:|
  Rat   540 PCCNNTSCLFQSRGYECRDAVNSCDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRD 604

  Fly   823 -----------TGSICLAY------GLESCQCIPGPQDDRIKSCE---------LCC-------- 853
                       :||....|      |.|...|  |...||...|.         ||.
  Rat   605 NQCQYIWGTKASGSDKFCYEKLNTEGTEKGNC--GKDGDRWIQCSKHDVFCGFLLCTNLTRAPRI 667

  Fly   854 -KLPGEDSP-----------CRSSFEWNEAPFDVPDMYSKPGTPCNDYNGYCDVFQKCREVD--- 903
             :|.||..|           |..:....:...||.  |.:.||||.......|  :||.::.
  Rat   668 GQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVG--YVEDGTPCGPSMMCLD--RKCLQIQALN 728

  Fly   904 -PSGPLATLRKL 914
             .|.||.:..|:
  Rat   729 MSSCPLDSKGKV 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	53/252 (21%)
		Disintegrin	720..801	CDD:459709	31/83 (37%)
Adam23	NP_001025070.3	None