DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Kul and Adam10

DIOPT Version :10

Sequence 1:NP_651716.1 Gene:Kul / 43501 FlyBaseID:FBgn0039688 Length:1537 Species:Drosophila melanogaster
Sequence 2:NP_062127.1 Gene:Adam10 / 29650 RGDID:2032 Length:749 Species:Rattus norvegicus


Alignment Length:972 Identity:320/972 - (32%)
Similarity:434/972 - (44%) Gaps:288/972 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 VLFLWLLWLPGEILAIPTPLKLPG-YTHRLTPYIKHWEAANFDRQVLQAAQVRHLEQARFRQKRE 75
            ||.|.|.|..|          |.| |.:.|..||:|:|..:::        |..|.|...|.||.
  Rat     6 VLILLLSWAAG----------LGGQYGNPLNKYIRHYEGLSYN--------VDSLHQKHQRAKRA 52

  Fly    76 VTPSASGLAHTIRLNFSAHDRDFRLVLRQQPHSVFAHDVEIENTLGPIDYDVSRIYTGSL--EDD 138
            |:.....|.    |:|.||.|.|.|.:::.. |:|:.:.::|.:...:|||.|.||||.:  |:.
  Rat    53 VSHEDQFLL----LDFHAHGRQFNLRMKRDT-SLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEG 112

  Fly   139 EAAHVQAILTSDNLLDGTIETQAEHYYIEPAHRYSQQLAESGVHSIVYKLSDVNMQKQQFTGGGL 203
            ..:|...:   |...:|.|:|:...:|||||.||.:... ...||::|...|:|...:....|| 
  Rat   113 SFSHGSVV---DGRFEGFIQTRGGTFYIEPAERYIKDRI-LPFHSVIYHEDDINYPHKYGPQGG- 172

  Fly   204 NSATPAKTHCASEKLRKKRWLPEELAMSDAPAPTYNRNPPLPLDLEVPYNDDFRVLASEEDKSEE 268
                 ...|...|::||                                                
  Rat   173 -----CADHSVFERMRK------------------------------------------------ 184

  Fly   269 SPRKYPTTSTTRSTVRSTESFLATLTKPTSNRNILVNNYNPSNLGEGSRSYSSGNNNANSNSNNN 333
                                                  |..:.:.||:|::|             
  Rat   185 --------------------------------------YQMTGVEEGTRAHS------------- 198

  Fly   334 NSNNNNNNNNSNNNVRKLYTKHKNIIVSTYNRPIEPEFGTPYEEPNNNGTRELPSNFFNANWTTL 398
                                                      ||                     
  Rat   199 ------------------------------------------EE--------------------- 200

  Fly   399 FLGNNNNGNDRPSHKTHVEIITKNGATKKPNIIVNNYNPEIIFAPNPHNPSFNSMMMTNLLSGRG 463
                                                           |..|.             
  Rat   201 -----------------------------------------------HAASM------------- 205

  Fly   464 GEDIHSSPRLLYDRKTTCMLYLQADHTFFQKMGSDEASIEAITRHVQRANTIYRNTDFNNDGKPD 528
            |.::....|.....:.||.||:|.||.||:..|:.||.|..|:.||:..:|||:.|||:.   ..
  Rat   206 GPELLRKKRTTLAERNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSG---IR 267

  Fly   529 NITFMIKRIKVHNMNAMKDPS--YRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGL 591
            ||:||:|||:::..:..|||:  :||| |.||||||||.||:::|.:||||:||.|||:.|.|||
  Rat   268 NISFMVKRIRINTTSDEKDPTNPFRFP-NIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGL 331

  Fly   592 AWTG-DLKNAGGVCEKNGHYR-GSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDP 654
            ||.| ...::||:|||:..|. |..|||||||:|:.|||.||||.|||:|.|||:|||||||||.
  Rat   332 AWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDS 396

  Fly   655 -EQCTPG-------GEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCFTEPQS 711
             .:||||       .|:||:||:||||||||.||||||.||:::|..||..|..:   ||.|...
  Rat   397 GTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNN---CFVESGQ 458

  Fly   712 SICGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKF 776
            .|||||:||.||:||||:.:.|||.|||. :.||  :...|.|.|..:||||||||||..|..|.
  Rat   459 PICGNGMVEQGEECDCGYSDQCKDECCFD-ANQP--EGKKCKLKPGKQCSPSQGPCCTAQCAFKS 520

  Fly   777 -GDKCRDDNGCRDPSFCDGRVPQCPPSVNKPNKTICNKEF-VCYMGDCTGSICLAYGLESCQCIP 839
             .:|||||:.|.....|:|....||.|..|||.|.||:.. ||..|.|.||||..|.||.|.|..
  Rat   521 KSEKCRDDSDCAKEGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYDLEECTCAS 585

  Fly   840 GPQDDRIKSCELCCKLPGEDSPCRS--SFEWNEAPFDVPDMYSKPGTPCNDYNGYCDVFQKCREV 902
            ....|..:.|.:||......|.|.|  |.:||: .|:...:..:||:||||:.||||||.:||.|
  Rat   586 SDGKDDKELCHVCCMKKMAPSTCASTGSLQWNK-QFNGRTITLQPGSPCNDFRGYCDVFMRCRLV 649

  Fly   903 DPSGPLATLRKLLLSEESIASFKKWMQHNWYTVALAAVGVILLLALSTKLLA---KRSNLKL 961
            |..||||.|:|.:.|.:...:..:|:..:|:.|.|..:.:|:|:|...|:.:   ..||.||
  Rat   650 DADGPLARLKKAIFSPQLYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKL 711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KulNP_651716.1 Pep_M12B_propep 70..186 CDD:460254 38/117 (32%)
ZnMc_TACE_like 479..713 CDD:239798 133/245 (54%)
Disintegrin 720..801 CDD:459709 39/81 (48%)
Adam10NP_062127.1 Pep_M12B_propep 46..156 CDD:460254 38/118 (32%)
Cysteine switch 171..178 3/12 (25%)
ZnMc_TACE_like 221..460 CDD:239798 133/245 (54%)
DISIN 467..546 CDD:214490 39/81 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 705..749 4/7 (57%)
SH3-binding. /evidence=ECO:0000255 709..716 2/3 (67%)
SH3-binding. /evidence=ECO:0000255 723..729
Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000250|UniProtKB:O35598 735..749
Blue background indicates that the domain is not in the aligned region.

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