DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kul and ADAM8

DIOPT Version :10

Sequence 1:NP_651716.1 Gene:Kul / 43501 FlyBaseID:FBgn0039688 Length:1537 Species:Drosophila melanogaster
Sequence 2:XP_047280379.1 Gene:ADAM8 / 101 HGNCID:215 Length:847 Species:Homo sapiens


Alignment Length:702 Identity:169/702 - (24%)
Similarity:258/702 - (36%) Gaps:193/702 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   440 IFAPNPHNPSFNSMMMTNLLSGRGGEDIHSSPRLLYDRKTTCM-LYLQADHTFFQKMGSDEASIE 503
            :|.|.|                  |:.:.|       |:|..: ||:..|:..||.:||:.|...
Human   208 VFRPRP------------------GDSLPS-------RETRYVELYVVVDNAEFQMLGSEAAVRH 247

  Fly   504 AITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVHN----MNAMKDPSYRFPGNYGVEKFLEL 564
            .:...|...:.:|:..:|.         .::..:::.|    .:...|||..      :|..|..
Human   248 RVLEVVNHVDKLYQKLNFR---------VVLVGLEIWNSQDRFHVSPDPSVT------LENLLTW 297

  Fly   565 FSEED-----YDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTL 624
            .:.:.     :|.   ..:.|..||...|:|.|      ....:|   .|..|::..        
Human   298 QARQRTRRHLHDN---VQLITGVDFTGTTVGFA------RVSAMC---SHSSGAVNQ-------- 342

  Fly   625 LNYGKHVPPAVSHVTLAHEIGHNFGSPHDPE----QCTPGGEDGNFIMFARATSGDKKNNNKFST 685
             ::.|: |..|: .|:|||:|||.|..||..    :|....|.|..||   |.|........||.
Human   343 -DHSKN-PVGVA-CTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIM---AGSIGSSFPRMFSD 401

  Fly   686 CSLKSIEPVLNAKARSMKGCFTE-PQSS------ICGNGVVEPGEQCDCGWEEDCKDSCCFPMSR 743
            ||...:|..|.   |....|... |..|      :|||..||.|||||||..|||::.||     
Human   402 CSQAYLESFLE---RPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCC----- 458

  Fly   744 QPRLDETPCTLTPHARCSPSQGPCCTTDCKLK-FGDKCRDDNG-CRDPSFCDGRVPQCPPSVNKP 806
                :.|.|.|...|:|  :.|.|| .:||:| .|:.||.... |....|||||.|:||....:.
Human   459 ----NSTTCQLAEGAQC--AHGTCC-QECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 516

  Fly   807 NKTICNKEFVCYMGDC--TGSICLAY-------GLESC---QCIPGPQDDRIKSCELC----CKL 855
            |.|.|:..: ||.|.|  ....|.|:       ..|||   ..:||.:..|.:: ::|    || 
Human   517 NGTPCSGGY-CYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRA-DMCGVLQCK- 578

  Fly   856 PGEDSP----------CRS-SFEWNEAPFDVPDMYSKPGTPCN---------------------- 887
             |...|          |.: :.|...|...||:     ||.|.                      
Human   579 -GGQQPLGRAICIVDVCHALTTEDGTAYEPVPE-----GTRCGPEKVCWKGRCQDLHVYRSSNCS 637

  Fly   888 ---DYNGYCDVFQKCREVDPSGPLATLRKLLLSEESIASFKKWMQHNWYTVALAAVGVILLLALS 949
               ..:|.|:..|:|.......|....:  ||:|...||....:    :.|.:..:..::|:.|:
Human   638 AQCHNHGVCNHKQECHCHAGWAPPHCAK--LLTEVHAASGSLPV----FVVVVLVLLAVVLVTLA 696

  Fly   950 TKLLAKRSNLKLKSVTIIHSATTETVRLPENNNGVIVHTAVRTKVPFK----KKVRGERTKKPGT 1010
            ..::.:::..::.|..:....|.       ..:..:.|.|. ::||.|    ...||.:...|.|
Human   697 GIIVYRKARSRILSRNVAPKTTM-------GRSNPLFHQAA-SRVPAKGGAPAPSRGPQELVPTT 753

  Fly  1011 GAGVTAAAAVGTRNAAKSSA----NPEPKKTTRSQAMAKKKSFEEEPKKSSK 1058
            ..|..|      |:.|.|.|    .|.|..|..|..........:.||:..|
Human   754 HPGQPA------RHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIK 799

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KulNP_651716.1 Pep_M12B_propep 70..186 CDD:460254
ZnMc_TACE_like 479..713 CDD:239798 58/254 (23%)
Disintegrin 720..801 CDD:459709 35/82 (43%)
ADAM8XP_047280379.1 Pep_M12B_propep 65..178 CDD:460254
Reprolysin 223..423 CDD:426256 55/243 (23%)
DISIN 440..514 CDD:214490 36/85 (42%)
ACR 517..628 CDD:214743 28/119 (24%)
PHA03378 <729..847 CDD:223065 21/78 (27%)
Blue background indicates that the domain is not in the aligned region.

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