Protein Alignment Kul and adam22

DIOPT Version :10

• Sequence 1: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: XP_031759145.1
• Gene: adam22 / 100494669
• XenbaseID: XB-GENE-957019
• Length: 936
• Species: Xenopus tropicalis
• Alignment Length: 792
• Identity: 165/792 - (20%)
• Similarity: 262/792 - (33%)
• Gaps: 300/792 - (37%)

  Fly   471 PRLLYDRKTTCMLYLQADHTFFQK----MGSDEASIEAITRHVQRANTIYR---NT--------D 520
            ||.:.|......|.:..||..::|    :|...:..:::   |..|:.||:   ||        .
 Frog   233 PRNVEDETKYVELMIVNDHLMYKKHRLSVGHTNSYAKSV---VNMADLIYKEQLNTRIVLVAMET 294

  Fly   521 FNNDGK---PDNITFMIKRIKVHNMNAMKDPSYRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYR 582
            :..|.|   .:|....:|....:..:.:||.|                     ||   .::|:..
 Frog   295 WATDNKFSISENPLLTLKEFMKYRRDFIKDKS---------------------DA---VHLFSGS 335

  Fly   583 DFEMGTLGLAWTG---DLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEI 644
            .||....|.|:.|   .|...|||.|                     :||   |.|..||||..:
 Frog   336 QFESSRSGAAYIGGVCSLLKGGGVNE---------------------FGK---PDVMAVTLAQSL 376

  Fly   645 GHNFGSPHDPEQCTPG-------------GEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLN 696
            .||.|...|.::...|             |:.|.::            .:|||.|:::.....||
 Frog   377 AHNLGIFSDKKKLLSGECKCEDTWSGCIMGDIGYYL------------PSKFSVCNIEEYHEFLN 429

  Fly   697 AKARSMKGC-FTEPQSSI----CGNGVVEPGEQCDCGWEEDCK---DSCCFPMSRQPRLDETPCT 753
            ....|   | |.:|...:    ||||.||.||:||||...:|.   ..||           ..||
 Frog   430 NGGGS---CLFNKPLKLLDPPECGNGFVEAGEECDCGTIAECAVEGGECC-----------KKCT 480

  Fly   754 LTPHARCSPSQGPCCTTDCKLKFGDK---CRDD-NGCRDPSFCDGRVPQCPPSVNKPNKTIC-NK 813
            ||..:.|  |.|.|| :||  ||..|   ||:. |.|..|..|.|...|||.:::|.:...| :.
 Frog   481 LTQDSEC--SDGLCC-SDC--KFNPKEMICREAVNDCDIPETCTGNSSQCPANIHKLDGYQCESM 540

  Fly   814 EFVCYMGDC-----------------TGSICL----AYGLESCQC-------IPGPQDDRIKSCE 850
            :.:|:.|.|                 ....|.    ..|.|...|       |...:.|.:....
 Frog   541 QGLCFGGRCKTRERQCKYIWGEKVSAADKYCYEKLNIEGTEKGNCGRNKETWIQCNKQDVLCGYL 605

  Fly   851 LCCKLP-----GE-DSPCRSSFEWNEAPF------------DVPDMYSKPGTPCNDYNGYCDVFQ 897
            ||..:.     || |....:|...|:...            |....|.:.||||.  .|...:..
 Frog   606 LCTNISSVPRLGELDGDVTTSSVVNQGKLYNCSGGHVKLDEDTDLGYVEDGTPCG--TGMMCLEH 668

  Fly   898 KCREVDP---SGPLATLRKLLLSEESIASFKKWMQHNWYT------------------------- 934
            :|..:|.   |..|.:..|:.......::..|.:..:::|
 Frog   669 RCLPIDSFNFSTCLGSTNKICSGHGVCSNEVKCICDSFWTGDDCSNFLPYDGIIKPDEGHRDEGV 733

  Fly   935 ----VALAAV-GVILLLAL---------------------------------------------- 948
                :.:.|: |.||:|||
 Frog   734 ISTNIIIGAIAGTILVLALVLGITAWGYKNYRRERQIPQGDYVKKPGDADSFYSDLPPGVSSNSA 798

  Fly   949 --STKLLAKRSNLKLKSVTIIHSATTETV----------------RLPEN-------NNGVIVHT 988
              |.|..|..|:.::.:.:|.|.:.::.:                |:|:.       .||.....
 Frog   799 SSSKKRSAILSHFQISACSIPHYSISQNISLFCRRSNGLSHSWSERIPDTKHVSDVCENGRPRSN 863

  Fly   989 AVRTKV-PFKKKVRGERTKKPGTGAGVTAAAAVGTRNAAKSSANPEPKKTTRSQAMAKKKSF--- 1049
            :.:..| ..:||:||:|.:        ..:.:..|.:.|||     |..:|.|.|.::|..:
 Frog   864 SWQGNVSSSRKKLRGKRFR--------PRSNSTETLSPAKS-----PSSSTGSIASSRKYPYPMP 915

  Fly  1050 --EEEPKKSSKK 1059
              .:|.:|::|:
 Frog   916 PLPDEERKANKQ 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	56/268 (21%)
		Disintegrin	720..801	CDD:459709	33/87 (38%)
adam22	XP_031759145.1	Pep_M12B_propep	82..190	CDD:460254
		Reprolysin	241..440	CDD:426256	55/264 (21%)
		Disintegrin	455..528	CDD:459709	34/88 (39%)
		ACR	532..673	CDD:214743	25/142 (18%)
		EGF_2	688..712	CDD:400365	2/23 (9%)