Protein Alignment dmrt99B and DMRTA2

DIOPT Version :9

• Sequence 1: NP_524549.1
• Gene: dmrt99B / 43495
• FlyBaseID: FBgn0039683
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_115486.1
• Gene: DMRTA2 / 63950
• HGNCID: 13908
• Length: 542
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 177/625 - (28%)
• Similarity: 215/625 - (34%)
• Gaps: 282/625 - (45%)

  Fly    18 VLGAL--PPAFFLRAASERYQRTPKCARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVM 80
            |.|.|  .|...|||| |:|.||||||||||||||||||||||||||:||:||||||||||||||
Human    46 VAGGLLRGPPLLLRAA-EKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCLCAKCTLIAERQRVM 109

  Fly    81 AAQVALRRQQAQEENEARELGLLYTSVPG----QQNG----------------SDSATPTPHSPN 125
            ||||||||||||||||||||.|||.:..|    ..||                :|...|...:|.
Human   110 AAQVALRRQQAQEENEARELQLLYGTAEGLALAAANGIIPPRPAYEVFGSVCAADGGGPGAGAPA 174

  Fly   126 HSGSGGSGSGGSG--------------QNGVFHGGIPSPP------SDGFEASSTPNHHQQSQQQ 170
            .:|.|.:|:|||.              |.|  ..|.|.||      .||  |.|.|.
Human   175 GTGGGAAGAGGSEAKLQKFDLFPKTLLQAG--RPGSPLPPPVKPLSPDG--ADSGPG-------- 227

  Fly   171 QQAHHQQHLSHPHQQSQRFNGNESDTDGRTRSEHLSVGFSPTRTELDESPVSKRGAALSNETDQD 235
                                                          ..||..:.|:...|   .|
Human   228 ----------------------------------------------TSSPEVRPGSGSEN---GD 243

  Fly   236 TGSESGSPSSPRPKVAGLFNLTASLSPARTGPPSSPESDLDVDSAPDEATP----ENLSLKKEDS 296
            ..|.||||.:...|.||      ...|...||....|.|     :|..|:|    ......||:.
Human   244 GESFSGSPLARASKEAG------GSCPGSAGPGGGGEED-----SPGSASPLGSESGSEADKEEG 297

  Fly   297 QSPPNTPAENLHLLRSFSSSHAQGFLPYHHTQFLAAAGLPAHHHPAAHSPHHQQQQQQQQQQQNH 361
            ::.|                               |.||.....|
Human   298 EAAP-------------------------------APGLGGGSGP-------------------- 311

  Fly   362 LPQHHQQQQQQQQQQQRSPIDVLMRVFPNRRRSDVEQLMQRFRGDVLQAMECML----AGEDLGQ 422
                          :||:|:|:|.||||..||..:|.::|...|||:||:|.:|    .|...|.
Human   312 --------------RQRTPLDILTRVFPGHRRGVLELVLQGCGGDVVQAIEQVLNHHRGGLAAGL 362

  Fly   423 TPPQVP-------------------------------PSPPFPM--------------------- 435
            .|...|                               |..|.|:
Human   363 GPAAPPDKAAVGAAAAADDAWPSRVDAAAAAAAAAGGPGLPAPLQAGPAAPPHHRPLLAGAMAPG 427

  Fly   436 -------KSAFSPLVP-PSVFG--------------SPTHRYHPFMQAHAKRF-LTAPYAGTGYL 477
                   :||||||.| .|.||              ||....:....||::.. ..|||:..|.:
Human   428 ALGSLSSRSAFSPLQPNASHFGADAGAYPLGAPLGLSPLRLAYSAAAAHSRGLAFMAPYSTAGLV 492

  Fly   478 P-------------------GVLSAADIEQSESNGAGGIG 498
            |                   ...:||.:.:..:.|.|..|
Human   493 PTLGFRPPMDYAFSDLMRDRSAAAAAAVHKEPTYGGGLYG 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dmrt99B	NP_524549.1	DM	37..83	CDD:279137	43/45 (96%)
		CUE_DMA_DMRTA1	378..415	CDD:270600	18/36 (50%)
DMRTA2	NP_115486.1	DM	66..112	CDD:279137	43/45 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..316		41/251 (16%)
		CUE_DMA_DMRTA2	312..353	CDD:270601	20/40 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6705
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3743
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1573364at2759
OrthoFinder	1	1.000	-	-		FOG0003936
OrthoInspector	1	1.000	-	-		oto90419
orthoMCL	1	0.900	-	-		OOG6_108101
Panther	1	1.100	-	-	O	PTHR12322
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3693
SonicParanoid	1	1.000	-	-		X984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.950