Protein Alignment dmrt99B and DMRTB1

DIOPT Version :10

• Sequence 1: NP_524549.1
• Gene: dmrt99B / 43495
• FlyBaseID: FBgn0039683
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_149056.1
• Gene: DMRTB1 / 63948
• HGNCID: 13913
• Length: 342
• Species: Homo sapiens
• Alignment Length: 444
• Identity: 101/444 - (22%)
• Similarity: 142/444 - (31%)
• Gaps: 177/444 - (39%)

  Fly    32 SERYQRTPKCARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVMAAQVALRRQQAQEENE 96
            :::..|||||:||||||.:..:|||...|||:.|:|.||.||:|||::||||..|:.|.|:||.|
Human     2 ADKMVRTPKCSRCRNHGFLVPVKGHAGKCRWKQCLCEKCYLISERQKIMAAQKVLKTQAAEEEQE 66

  Fly    97 ARELGLLYTSVPGQQNGSDSATPTPHSPNHSGSGGSGSGGSGQNGVFHGGIPSPPSDGFEASSTP 161
            |    .|....|.|.:|:.:|.|.|                         :|.|     .||..|
Human    67 A----ALCAQGPKQASGAAAAAPAP-------------------------VPVP-----AASLRP 97

  Fly   162 NHHQQSQQQQQAHHQQHLSHPHQQSQRFNGNESDTDGRTRSEHLSVGFSPTRTELDESPVSKRGA 226
                                                           .||.....|..| ...|.
Human    98 -----------------------------------------------LSPGTPSGDADP-GPEGR 114

  Fly   227 ALSNETDQDTGSESGSPSSPRPKVAGLFNL-----TASLSPARTGPPSSPES---------DL-- 275
            |.:...:|.....:..|.:.:|.:.|..::     .|...|:..|||...|:         ||
Human   115 AAACFFEQPPRGRNPGPRALQPVLGGRSHVEPSERAAVAMPSLAGPPFGAEAAGSGYPGPLDLRR 179

  Fly   276 DVDSAP-----DEATPENLSLKKEDSQSPPNTPAENLHLLRSFSSSHAQGFLPYHHTQFLAAAGL 335
            .:.:.|     |...|.|::   .|....|..|..        ||.|.  :.|:......|..|:
Human   180 PMRTVPGPLFTDFVRPLNIN---PDRALGPEYPGG--------SSMHP--YCPFPLGYLDAPPGV 231

  Fly   336 PAHHHPAAHSPHHQQQQQQQQQQQNHLPQHHQQQQQQQQQQQRSPIDVLMRVFPNRRRSDVEQLM 400
            |.                  ||...|:                           :|.:.....|:
Human   232 PL------------------QQGFRHV---------------------------SRSQYQGGGLV 251

  Fly   401 QRFRGDVLQAMECMLAGEDLGQTPPQVPPSPPFPMKSAFSP---------LVPP 445
            ....||...:..       |...||.:||.||.|.:..|.|         |.||
Human   252 SEPGGDFQPSYY-------LPPPPPPLPPLPPLPPQPQFLPPGYLSALHFLPPP 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dmrt99B	NP_524549.1	DM	37..83	CDD:459924	28/45 (62%)
		CUE_DMA_DMRTA1	378..415	CDD:270600	4/36 (11%)
DMRTB1	NP_149056.1	DM	7..53	CDD:459924	28/45 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..131		11/92 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..342		16/61 (26%)