DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt99B and dmrt2a

DIOPT Version :9

Sequence 1:	NP_524549.1	Gene:	dmrt99B / 43495	FlyBaseID:	FBgn0039683	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_571027.1	Gene:	dmrt2a / 30129	ZFINID:	ZDB-GENE-990621-7	Length:	507	Species:	Danio rerio

Alignment Length:	375	Identity:	107/375 - (28%)
Similarity:	136/375 - (36%)	Gaps:	97/375 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RYQRTPKCARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVMAAQVALRRQQAQEENEAR 98
            :..|||||||||||||||.||||||:||||||.||.|.|:.|||||||||||||||||.|:.:
Zfish    54 KLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKK-- 116

  Fly    99 ELGLLYTSVPGQQNGSDSATPTP-----------HSPNHSGSGGSGSGGSGQNGVFHG---GIPS 149
              |:....:|.::.........|           :.|             .||..|.|   .:|.
Zfish   117 --GITGKQIPVERRNIYQRHIRPSTMLAKSILEGYRP-------------VQNDPFLGANPALPP 166

  Fly   150 PPSDG----------------FEASSTPNHHQQSQQQQQAH-----HQQHLSHPHQQSQRFNGNE 193
            |.||.                .|.........:|.|...|.     ...|.:..:.....|:...
Zfish   167 PLSDRMRKRRAFADKELETIMLEREYKERELLESTQSNSASLFMPGSMVHAAEYNSYKTAFSSAS 231

  Fly   194 SDTDGRTRSEHLSVGFSPTRTELDESPVSKRGAALSNETDQDTGSESGS----PSSPR----PKV 250
            :.:......:.| .||.|...:|.....:..|...:.|......|.:.:    |.|||    |:.
Zfish   232 APSTVEPSPKDL-CGFLPGCLDLSLQYAATGGTTANVELISSNVSVATTYRQYPLSPRFVMWPRG 295

  Fly   251 AG-----------LFNLTA--SLSPARTGPP---SSPESDLDVDSAP------DEATPENLSLKK 293
            :.           |.|.||  :|.|.....|   ||.||......||      ....||:
Zfish   296 SSSISDALLYQQCLLNATAVQNLKPGAVWDPKMMSSTESHPPEQDAPASRLEGSRVAPES----- 355

  Fly   294 EDSQSPPNTPAENLHLLRSFSSSHAQGFLPYHHTQ---FLAAAGLPAHHH 340
            .|.|..|......|    ..:......|.|...|.   |...||  :|.|
Zfish   356 SDLQPGPREAQTGL----GHNGGARSAFSPPKRTYGQVFSPQAG--SHEH 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt99B	NP_524549.1	DM	37..83	CDD:279137	38/45 (84%)
dmrt99B	NP_524549.1	CUE_DMA_DMRTA1	378..415	CDD:270600
dmrt2a	NP_571027.1	DM	57..103	CDD:279137	38/45 (84%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810