DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt99B and Dmrt3

DIOPT Version :9

Sequence 1:	NP_524549.1	Gene:	dmrt99B / 43495	FlyBaseID:	FBgn0039683	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001099828.1	Gene:	Dmrt3 / 293976	RGDID:	1306043	Length:	476	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	135/492 - (27%)
Similarity:	177/492 - (35%)	Gaps:	214/492 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QRTPKCARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVMAAQVALRRQQAQEENEAREL 100
            ||||||||||||||:|.|||||||||::||.|.||.||.|||||||||||||||||.|.
  Rat    24 QRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANES------ 82

  Fly   101 GLLYTSVPGQQNGSDSATPTPHSPNHSGSGGSGSGGSGQNGVFHGGIPSPPSDGFEASSTPNHHQ 165
              |.:.:|      ||..                           .:|.||..| :|::|.....
  Rat    83 --LESLIP------DSLR---------------------------ALPGPPPPG-DAAATAATAS 111

  Fly   166 QSQQQQQAHHQQHLSHPHQQSQRFNGNESDTDGRTRSEHLSVGFSPTR--TELDESPVSKRGAAL 228
            ||....||      |.|.                          :|.|  |||      ...|||
  Rat   112 QSSPASQA------SQPP--------------------------APPRPATEL------AAAAAL 138

  Fly   229 SNETDQDTGSESGSPSSPRPKVAGLFNLTASLSPARTGPPSSPE------SDLDVD--SAPDEA- 284
            ....:...|:.....:.|            .|:..|.|..||.:      ||.|.|  |:||..
  Rat   139 RWVAEPQPGTLPAQIAKP------------DLTEDRLGDSSSADNAAESFSDKDTDQRSSPDVVK 191

  Fly   285 -----TPENLSLKKEDS------------QSPPNTP---AENLHLLRSFSSSHAQGFLPYHHTQF 329
                 |||:..:...|.            :|.|::|   ||..|||....|....  ||:
  Rat   192 SKNCFTPESPEIVSVDEGGYAVQKNGGNPESCPDSPKYHAEQSHLLIEGPSGTVS--LPF----- 249

  Fly   330 LAAAGLPAHHHPAAHSPHHQQQQQQQQQQQNHLPQHHQQQQQQQQQQQRSPIDVLMRVFPNRRRS 394
                .|.|:                                       |.|::||.::|||::.:
  Rat   250 ----SLKAN---------------------------------------RPPLEVLKKIFPNQKPT 271

  Fly   395 DVEQLMQRFRGDVLQAMECML------AGED-------------------LGQTPP--------- 425
            .:|.:::...||::.|:|.:|      ||.:                   ||..|.
  Rat   272 VLELILKGCGGDLVSAVEVLLSSRSSAAGAERTAEESLVLPSSGHIFEHTLGSYPISSSKWSVGS 336

  Fly   426 --QVPPSPPFPMKSAFSPLVPPSVFGSPTHRYHPFMQ 460
              :||.:..|   ||.|..|.|:....|..  |||.|
  Rat   337 AFRVPDTLRF---SADSSNVVPNPLAVPLQ--HPFPQ 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt99B	NP_524549.1	DM	37..83	CDD:279137	37/45 (82%)
dmrt99B	NP_524549.1	CUE_DMA_DMRTA1	378..415	CDD:270600	12/36 (33%)
Dmrt3	NP_001099828.1	DM	25..71	CDD:395608	37/45 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..130		16/100 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..195		14/59 (24%)
		CUE_DMA_DMRTA3	253..295	CDD:270602	14/80 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12176
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12322
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910