Protein Alignment dmrt99B and Dmrta2

DIOPT Version :9

• Sequence 1: NP_524549.1
• Gene: dmrt99B / 43495
• FlyBaseID: FBgn0039683
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_758500.2
• Gene: Dmrta2 / 242620
• MGIID: 2653629
• Length: 531
• Species: Mus musculus
• Alignment Length: 595
• Identity: 172/595 - (28%)
• Similarity: 216/595 - (36%)
• Gaps: 232/595 - (38%)

  Fly    18 VLGAL--PPAFFLRAASERYQRTPKCARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVM 80
            |.|.|  .|...|||| |:|.||||||||||||||||||||||||||:||:||||||||||||||
Mouse    45 VAGGLLRAPPLLLRAA-EKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCLCAKCTLIAERQRVM 108

  Fly    81 AAQVALRRQQAQEENEARELGLLYTSVPGQQNGSDSATPTPHSPNHSGSGGSGSGGSGQNGVFHG 145
            ||||||||||||||||||||.|||.:                        ..|...:..||:.
Mouse   109 AAQVALRRQQAQEENEARELQLLYGT------------------------AEGLALAAANGII-- 147

  Fly   146 GIPSPPSDGFEASSTPNHHQQSQQQQQAHHQQHLSHPHQQSQRFNGNESDTDGRTRSEHLSVGFS 210
                ||...:|..                                |:...|||.....
Mouse   148 ----PPRPAYEVF--------------------------------GSVCATDGGGPGA------- 169

  Fly   211 PTRTELDESPVSKRGAALSNETD-------QDTGSESGSPSSPRPKVAGLFNLTASLSPARTGPP 268
                   .:|....|.|...|..       ..|..::|.|.||:|                  ||
Mouse   170 -------GAPAGSAGGAGGAEAKLQKFDLFPKTLLQAGRPDSPQP------------------PP 209

  Fly   269 SSPESDLDVDSAPDEATPE---NLSLKKEDSQSPPNTPAENLHLLRSFSSSHAQGFLPYHHTQFL 330
            ..|.|....||.|..::||   ....:..|.:|...:|     |.|  :|..|.|..|    ...
Mouse   210 GKPLSPDGADSGPRTSSPEVRPGSGSENGDGESFSGSP-----LAR--ASKEAGGSCP----GSA 263

  Fly   331 AAAGLPAHHHPAAHSPHHQQQQQQQQQQQNHL-----------PQHHQQQQQQQQQQQRSPIDVL 384
            .|.|......|.:.||...:...:..:::...           |            :||:|:|:|
Mouse   264 GAGGGGEEDSPGSSSPLGSESGSEADKEEAEAAPTPGLGGGPGP------------RQRTPLDIL 316

  Fly   385 MRVFPNRRRSDVEQLMQRFRGDVLQAMECML------------------------AGEDLG---- 421
            .||||..||..:|.::|...|||:||:|.:|                        |.||..
Mouse   317 TRVFPGHRRGVLELVLQGCGGDVVQAIEQVLNHHRGGLAAGLGPAAPLEKAAVSAAVEDAWPGRV 381

  Fly   422 --------------QTPPQVPP----------SP----PFPMKSAFSPLVP-PSVFG-------- 449
                          ||.|..||          :|    ....:||||||.| .|.||
Mouse   382 EAAAAGGAGLPAPLQTGPTAPPHHRPLLAGAMTPGALGSLSSRSAFSPLQPNASHFGADAGAYPL 446

  Fly   450 ------SPTHRYHPFMQAHAKRF-LTAPYAGTGYLP-------------------GVLSAADIEQ 488
                  ||....:....||::.. ..|||:..|.:|                   ...:||.:.:
Mouse   447 GAPLGLSPLRLAYSAAAAHSRGLAFMAPYSTAGLVPTLGFRPPMDYAFSDLMRDRSAAAAAAVHK 511

  Fly   489 SESNGAGGIG 498
            ....|.|..|
Mouse   512 EPGYGGGLYG 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dmrt99B	NP_524549.1	DM	37..83	CDD:279137	43/45 (96%)
		CUE_DMA_DMRTA1	378..415	CDD:270600	18/36 (50%)
Dmrta2	NP_758500.2	DM	65..111	CDD:366283	43/45 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	197..312		31/155 (20%)
		CUE_DMA_DMRTA2	308..349	CDD:270601	20/40 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6689
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3790
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1573364at2759
OrthoFinder	1	1.000	-	-		FOG0003936
OrthoInspector	1	1.000	-	-		otm43630
orthoMCL	1	0.900	-	-		OOG6_108101
Panther	1	1.100	-	-	O	PTHR12322
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3693
SonicParanoid	1	1.000	-	-		X984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.950