DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt99B and DMRT1

DIOPT Version :9

Sequence 1:	NP_524549.1	Gene:	dmrt99B / 43495	FlyBaseID:	FBgn0039683	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_011516072.1	Gene:	DMRT1 / 1761	HGNCID:	2934	Length:	390	Species:	Homo sapiens

Alignment Length:	348	Identity:	76/348 - (21%)
Similarity:	109/348 - (31%)	Gaps:	137/348 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 RFNGNESD-TDGRTRSE---HLSVGFSPTRTELDESPVSKR--GAALSNETDQ---------DTG 237
            |.:|:..| :|...|:|   .|..|| ||.:.    ||.:|  |.:|.:...:         ::|
Human    39 RRSGSAGDASDPARRAELRASLGSGF-PTISH----PVFRRSCGGSLCSRVPEIPDPALRAGNSG 98

  Fly   238 -SESGSPSSPRPKV----AGLFNLTASLSPARTGPPS--------SPESDLDVDSAPDEATPENL 289
             ..||.|..||.:|    .|...|..|...:.  |||        :.|.:|.:.......:...|
Human    99 VRPSGLPRDPRARVPTELGGFIALEESSGSSL--PPSEVALRRQQAQEEELGISHPIPLPSAAEL 161

  Fly   290 SLKKED--------------SQSPP----------------NTPA-------ENLHLLRS----F 313
            .:|:|:              ||.||                :.||       ||...|.|    :
Human   162 LVKRENNGSNPCLMTECSGTSQPPPASVPTTAASEGRMVIQDIPAVTSRGHVENTPDLVSDSTYY 226

  Fly   314 SSSHAQGFLPYHHTQF--------LAA------AGLPAHHHPAAHS------PHHQQQQQQQQQQ 358
            ||.:.....||::..:        |||      .|.|....|..:|      |:...|...|.||
Human   227 SSFYQPSLFPYYNNLYNCPQYSMALAADSASGEVGNPLGGSPVKNSLRGLPGPYVPGQTGNQWQQ 291

  Fly   359 QNHLPQHHQQQQQQQQQQQRSPIDVLMRVFPNRRRSDVEQLMQRFRGDVLQAMECMLAGEDLGQT 423
            ..::...|....|.:......|        |:.                            |||:
Human   292 MKNMENRHAMSSQYRMHSYYPP--------PSY----------------------------LGQS 320

  Fly   424 PPQV-----PPSPPFPMKSAFSP 441
            .||.     .||.|....|.|||
Human   321 VPQFFTFEDAPSYPEARASVFSP 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt99B	NP_524549.1	DM	37..83	CDD:279137
dmrt99B	NP_524549.1	CUE_DMA_DMRTA1	378..415	CDD:270600	2/36 (6%)
DMRT1	XP_011516072.1	Dmrt1	146..218	CDD:289167	12/71 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810