DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gycalpha99B and CYR1

DIOPT Version :9

Sequence 1:NP_477088.2 Gene:Gycalpha99B / 43493 FlyBaseID:FBgn0013972 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_012529.3 Gene:CYR1 / 853452 SGDID:S000003542 Length:2026 Species:Saccharomyces cerevisiae


Alignment Length:589 Identity:123/589 - (20%)
Similarity:206/589 - (34%) Gaps:180/589 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 YRQNWPNIHKLKL----DPQTF--KSCANYDYLADIQELLLKMDEASASEILVLLGEELITCCCT 127
            |..||.|..:||.    ..:.|  ||..::|..||:.:|.:...       |.:||...:|...|
Yeast  1278 YDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLPQ-------LKVLGLMDVTLNTT 1335

  Fly   128 GIIER--AFRCLGTDLQEFLGSLDGVYDVL----KLQEEDVT--------DTGFVC--------A 170
            .:.:.  .|| |.|......|...||.|.|    .:...|||        |...:|        |
Yeast  1336 KVPDENVNFR-LRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNA 1399

  Fly   171 GEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMG 235
            ..|..|....|.:...:|   ::.|.|...:.|.|||      .|.|:.:| .|.|:     :.|
Yeast  1400 DYGHNISRIVRDIYDKIL---IRQLERYGDETDDNIK------TALRFSFL-QLNKE-----ING 1449

  Fly   236 RPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADF 300
            ...||          .|.::.::|.           :..:::.....|...|| .||:...:.| 
Yeast  1450 MLNSV----------DNGADVANLS-----------YADLLSGACSTVIYIRG-KKLFAANLGD- 1491

  Fly   301 GCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIG---LNNP--PGAVD----------FPAIGLE 350
             |.|....:....:.||.:.....|..|....|.   :||.  .|.||          .|.|...
Yeast  1492 -CMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHAS 1555

  Fly   351 IKGQMVHCPESNSLLFIGSPFL-DGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRM 414
            ....:|...:::.:|.:.:..| :.:|..|     :.||...::|                    
Yeast  1556 PDISVVTLTKADEMLIVATHKLWEYMDVDT-----VCDIARENST-------------------- 1595

  Fly   415 DKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEK----LWLGSSIDAK-TYPDVTI------- 467
            |.::.:.|..:.|:.....:|:::|.|.....|.::    |...|.:..: |:.|.|:       
Yeast  1596 DPLRAAAELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEI 1660

  Fly   468 ---------LFSDIVGFTSICSRATPFMVISMLEGLYKDFDEF----CDFFDVYKVETIGDAYCV 519
                     :|:||...|.:..     :..:.:....|..::.    ...:..|:|:|.|||:.|
Yeast  1661 SPPTGNLAMVFTDIKSSTFLWE-----LFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMV 1720

  Fly   520 A-----SGLHRASIYDAHKVAW---MALKMIDA-CSKHIT--HDGEQI------------KMRIG 561
            |     |||           .|   :.||::|| ..:.||  .||.|:            .:|:|
Yeast  1721 AFPTPTSGL-----------TWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMG 1774

  Fly   562 LHTG 565
            :|.|
Yeast  1775 IHWG 1778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gycalpha99BNP_477088.2 HNOB 76..208 CDD:285002 38/159 (24%)
HNOBA 259..451 CDD:285003 36/211 (17%)
CYCc 430..619 CDD:214485 39/184 (21%)
Guanylate_cyc 457..647 CDD:278633 33/153 (22%)
CYR1NP_012529.3 Ad_cyc_g-alpha 368..418 CDD:369912
RA_PHLPP_like 678..776 CDD:340473
PLN00113 792..>1273 CDD:215061
leucine-rich repeat 796..817 CDD:275380
leucine-rich repeat 818..839 CDD:275380
leucine-rich repeat 840..864 CDD:275380
leucine-rich repeat 865..887 CDD:275380
leucine-rich repeat 888..910 CDD:275380
leucine-rich repeat 911..933 CDD:275380
leucine-rich repeat 934..956 CDD:275380
leucine-rich repeat 957..978 CDD:275380
leucine-rich repeat 979..1018 CDD:275380
leucine-rich repeat 1019..1041 CDD:275380
leucine-rich repeat 1042..1065 CDD:275380
leucine-rich repeat 1066..1088 CDD:275380
leucine-rich repeat 1089..1111 CDD:275380
leucine-rich repeat 1167..1187 CDD:275380
leucine-rich repeat 1191..1211 CDD:275380
leucine-rich repeat 1236..1258 CDD:275380
leucine-rich repeat 1259..1287 CDD:275380 4/8 (50%)
PP2C 1374..1617 CDD:395385 57/306 (19%)
CYCc 1613..1825 CDD:214485 39/182 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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