DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Adcy7

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_445848.1	Gene:	Adcy7 / 84420	RGDID:	619966	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	87/375 - (23%)
Similarity:	155/375 - (41%)	Gaps:	99/375 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 IGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLR 411
            :||::.        :|:::.:|..|         .|.|... .|.||:|::.:...:...   :|
  Rat   178 LGLQLL--------ANAVILLGGNF---------TGAFHKH-QLQDASRDLFIYTVKCIQ---IR 221

  Fly   412 RRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIA--------EKLWLGS-----------SI 457
            |::            .|.|.:::|  ||..:.||.|:        |:|..|.           |:
  Rat   222 RKL------------RVEKRQQEN--LLLSVLPAHISMGMKLAIIERLKEGGDRHYTPDNNFHSL 272

  Fly   458 DAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASG 522
            ..|.:.:|:||::||||||.:.|..:|..::.:|..|:..||:.....:..:::.:||.|...||
  Rat   273 YVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSG 337

  Fly   523 LHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVT 587
            |..:....|.....|.|.:.:|..:.....|..|.||:|:|:|.||.||:|.:..:|.::.|.|:
  Rat   338 LPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVS 402

  Fly   588 IANKFESGSEALKINVSPTTKDWLTKHEGFEFE---------------------LQPR--DPSFL 629
            :||:.|:.....:::::..|.:.|.|  .:|.|                     :.||  .|...
  Rat   403 LANRMEAAGVPGRVHITEATLNHLDK--AYEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPLP 465

  Fly   630 PKEFPNPGGTET---------CYFLESF-----------RNPALDSELPL 659
            ......|.|..|         ..:|||:           |.....||:|:
  Rat   466 SHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSEIPI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	22/111 (20%)
		CYCc	430..619	CDD:214485	58/207 (28%)
		Guanylate_cyc	457..647	CDD:278633	56/221 (25%)
Adcy7	NP_445848.1	AC_N	<21..251	CDD:318454	21/107 (20%)
		Guanylate_cyc	272..422	CDD:306677	44/149 (30%)
		DUF1053	487..593	CDD:399378	7/29 (24%)
		Guanylate_cyc	891..1087	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810