DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Adcy5

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	304	Identity:	76/304 - (25%)
Similarity:	140/304 - (46%)	Gaps:	53/304 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 LDGLTCNGLFISDIPLHDATREVILVGEQAR------------------AQDGLRRRMDKIKNSI 421
            |.|:..:.|.:: |.||...::..|:.:...                  |:...|:...:.:..|
  Rat   353 LSGVLLSALHLA-ISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECI 416

  Fly   422 EEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAK------------TYPDVTILFSDIVG 474
             :|.....:|.::...||..:.|..:|  :.:.:.|:||            .:.:|:|||:||.|
  Rat   417 -QARLHSQRENQQQERLLLSVLPRHVA--MEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEG 478

  Fly   475 FTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMAL 539
            |||:.|:.|...::..|..|:..||:........:::.:||.|...|||..|....||....|.:
  Rat   479 FTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGM 543

  Fly   540 KMIDACS--KHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKIN 602
            .||:|.|  :.:|  |..:.||:|:|:|.|..||:|.:..::.::.:.||:||..|:|.:|.:|:
  Rat   544 DMIEAISLVREVT--GVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIH 606

  Fly   603 VSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTETCYFLE 646
            ::..|.::|..    ::|::           |..||....|..|
  Rat   607 ITKATLNYLNG----DYEVE-----------PGCGGERNAYLKE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	16/93 (17%)
		CYCc	430..619	CDD:214485	59/202 (29%)
		Guanylate_cyc	457..647	CDD:278633	60/204 (29%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	19/109 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..634	CDD:306677	56/189 (30%)
		DUF1053	669..761	CDD:399378
		Guanylate_cyc	1063..1257	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810