DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	715	Identity:	259/715 - (36%)
Similarity:	384/715 - (53%)	Gaps:	122/715 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CPFFRRADSLTRQPSVIAEP-----GG-------------------HWALEDEELSDDALTLTHL 43
            |||     ||.....|..||     ||                   ..:|...:.|.:.:.|..|
Mouse    15 CPF-----SLLAPGQVPKEPTEEVAGGSEGCQATLPICQYFPEKNAEGSLPQRKTSRNRVYLHTL 74

  Fly    44 QMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELLLKMDEA 108
            ..:|..|..|..|.||.|:...:||        ||::.:.::.:.       .|:::::.:...|
Mouse    75 AESICKLIFPECERLNLALQRTLAK--------HKIEENRKSSEK-------EDLEKIIAEEAIA 124

  Fly   109 SASEILVL---LGEELITCC------CTGIIERAFRCLGTDLQEFLGSLDGVYDVLK----LQEE 160
            :.:.:..|   |||||...|      ..|::       |..|::||.|..   .:||    .||.
Mouse   125 AGAPVEALKDSLGEELFKICYEEDEHILGVV-------GGTLKDFLNSFS---TLLKQSSHCQEA 179

  Fly   161 D----VTDTGFVCAGEGE----LIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEP--VEGDA 215
            :    :.|...:|..:.:    :.:...:...|.||.|.:||..|:||:..|.:.:.|  ...|.
Mouse   180 ERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSDC 244

  Fly   216 RRY----RYLFSL-VKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFI 275
            ..:    ..|:|: ||....::..|:|.| |..||                 :|.|||.||:||:
Mouse   245 TEFVNQPYLLYSVHVKSTKPSLSPGKPQS-SLVIP-----------------ASLFCKTFPFHFM 291

  Fly   276 MNEQLELVQLGRGFSKLY-------KPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLI 333
            ::..|.::|||.|..:|.       ||...:|       |:...|| :...|..|:......|:|
Mouse   292 LDRDLAILQLGNGIRRLVNKRDFQGKPNFEEF-------FEILTPK-INQTFSGIMTMLNMQFVI 348

  Fly   334 GLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVI 398
            .:.....:|...:..:::||||::..||:::||:|||.:|.|:..|..||::||||:|:|.|:|:
Mouse   349 RVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVV 413

  Fly   399 LVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYP 463
            |:||||||||||::|:.|:|.::|.|:.|:.:|:|:.|.||..|||:|:|::||.|..:.||.:.
Mouse   414 LIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQIVQAKKFS 478

  Fly   464 DVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASI 528
            :||:|||||||||:|||:.:|..||:||..||..||:.|...|||||||||||||||.||||.|.
Mouse   479 EVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESD 543

  Fly   529 YDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFE 593
            ..|.::|.|||||::..::.::..||.||||||||:|:|.|||||.|||||||||::||:|||||
Mouse   544 THAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 608

  Fly   594 SGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPN--PGGTETCYFLESFRNPALDSE 656
            |.|...||||||||...|....||.|  .||....||..||:  ||   .|:||:::.:...:|:
Mouse   609 SCSVPRKINVSPTTYRLLKDCPGFVF--TPRSREELPPNFPSDIPG---ICHFLDAYHHQGPNSK 668

Fly 657 656
Mouse 669 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	33/152 (22%)
		HNOBA	259..451	CDD:285003	76/198 (38%)
		CYCc	430..619	CDD:214485	112/188 (60%)
		Guanylate_cyc	457..647	CDD:278633	111/191 (58%)
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	78/213 (37%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	102/172 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2953
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1867
Isobase	1	0.950	-	0	Normalized mean entropy	S5432
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43925
orthoMCL	1	0.900	-	-		OOG6_106420
Panther	1	1.100	-	-	LDO	PTHR45655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4585
SonicParanoid	1	1.000	-	-		X3073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.800