DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Phlpp1

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	251	Identity:	56/251 - (22%)
Similarity:	90/251 - (35%)	Gaps:	90/251 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RADSL-----------TRQPSVIAEPGGHWALEDEELSDDALTLTHLQMAIQLLTA-PSNEDLNT 60
            :||||           |..|:.::|.... .|::..|::::||    ...:.|||. |..:.|:.
  Rat   947 KADSLRFLNASANKLETLPPATLSEETSS-ILQELYLTNNSLT----DKCVPLLTGHPRLKILHM 1006

  Fly    61 AVTSLVAKYRQNWP---------------NIHKLKLDPQTFKSC-------ANYDYLADIQELL- 102
            |...|     |::|               :.:|||..|.|..:|       |:.:.:....|::
  Rat  1007 AYNRL-----QSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQ 1066

  Fly   103 ---LKMDEA----SASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEE 160
               :|..|.    |.|..|..|..:.:...|..:.|       ..|.|.|..        ||||.
  Rat  1067 LPEVKSTEGNGSLSRSSFLFPLFHQCVDLSCNELSE-------ITLPENLPP--------KLQEL 1116

  Fly   161 DVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKALTRM-LYKVDVNIKIEPVEGDA 215
            |:|       |...|....:          ||:.|..: .:|:|     :|..|||
  Rat  1117 DLT-------GNPRLALDHK----------SLELLNNIRCFKID-----QPSAGDA 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	32/147 (22%)
		HNOBA	259..451	CDD:285003
		CYCc	430..619	CDD:214485
		Guanylate_cyc	457..647	CDD:278633
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021
		RA_PHLPP1	<424..491	CDD:340760
		PH_PHLPP-like	498..594	CDD:270131
		PLN00113	602..>1109	CDD:215061	38/178 (21%)
		leucine-rich repeat	604..624	CDD:275380
		leucine-rich repeat	625..655	CDD:275380
		leucine-rich repeat	679..701	CDD:275380
		leucine-rich repeat	702..724	CDD:275380
		leucine-rich repeat	725..771	CDD:275380
		leucine-rich repeat	772..795	CDD:275380
		leucine-rich repeat	796..816	CDD:275380
		leucine-rich repeat	817..858	CDD:275380
		leucine-rich repeat	859..881	CDD:275380
		leucine-rich repeat	882..904	CDD:275380
		leucine-rich repeat	905..926	CDD:275380
		leucine-rich repeat	927..950	CDD:275380	1/2 (50%)
		leucine-rich repeat	951..974	CDD:275380	4/22 (18%)
		leucine-rich repeat	977..1000	CDD:275380	7/26 (27%)
		leucine-rich repeat	1001..1024	CDD:275380	5/27 (19%)
		leucine-rich repeat	1067..1112	CDD:275380	11/59 (19%)
		PP2Cc	1151..1403	CDD:214625	56/251 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900