DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and npr3

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_005165413.1	Gene:	npr3 / 569395	ZFINID:	ZDB-GENE-060531-91	Length:	503	Species:	Danio rerio

Alignment Length:	232	Identity:	49/232 - (21%)
Similarity:	89/232 - (38%)	Gaps:	42/232 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELLLKMDEASAS-- 111
            |:..|..|...::||.:.:.:  |.|.|....|..........|.:|..|....|||.|...:
Zfish    97 LVLGPVCEYAASSVTRVASHW--NIPVISAGALATGFNSKTPEYSHLTRIAPTYLKMAETFQAIF 159

  Fly   112 ------EILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVCA 170
                  ...::..::.....|...:|..|    |.|.|:..|.|  :.||...||.|...|.:.:
Zfish   160 GHFGWRTAYLIYDDDKDERNCYFTMEGVF----TVLSEYHISTD--FAVLNSNEERVDPDGIITS 218

  Fly   171 --GEGELIFTSERPVIAWLLLGS----LKALTRMLYKVDVNIKIEPVEGDARR-----------Y 218
              |...:|..|:..::..|:|.:    |.:.:.:.:.:::.......:|..||           |
Zfish   219 VYGSEVVIMCSKADIVRDLMLAAHRRKLTSDSHIFFNIELFNSSSYGDGSWRRRDKYDDEARAAY 283

  Fly   219 RYLFSLVKDNSQTMLMG-RP--TSVSKTIPETVQRSN 252
            .:|      |:.|:|.. :|  ...|..:.:::|:||
Zfish   284 SFL------NTVTLLRSTKPEFEDFSIEMKKSLQQSN 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	29/145 (20%)
		HNOBA	259..451	CDD:285003
		CYCc	430..619	CDD:214485
		Guanylate_cyc	457..647	CDD:278633
npr3	XP_005165413.1	Periplasmic_Binding_Protein_Type_1	29..416	CDD:299141	49/232 (21%)
		ANF_receptor	46..389	CDD:279440	49/232 (21%)
		TM_EphA1	436..468	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900