Protein Alignment Gycalpha99B and adcy7

DIOPT Version :9

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: XP_021333246.1
• Gene: adcy7 / 568726
• ZFINID: ZDB-GENE-040713-1
• Length: 1119
• Species: Danio rerio
• Alignment Length: 621
• Identity: 128/621 - (20%)
• Similarity: 225/621 - (36%)
• Gaps: 183/621 - (29%)

  Fly    78 KLKLDPQTFKSCANYDYLADIQELLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQ 142
            |..||.|..|..|.|...:.|.:.         .:.::|||..::||....::..:|:....:..
Zfish     6 KYSLDKQELKQEALYRKFSGISQY---------RQFVLLLGLSIVTCATLLVLFFSFKLKAQNHG 61

  Fly   143 EFLGSLDG-------VYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAW-LLLGSLKALTRM- 198
            .|:|.:.|       |:.::      .|:|            .|:|    | .|||.....|.:
Zfish    62 IFVGVVGGALCLFLAVFVLV------CTET------------LSQR----WRTLLGLGVWATHLT 104

  Fly   199 -----LYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASD 258
                 ::....:::|:|  .|...: :||.::  ...|||   |..:|..:..::..|.|
Zfish   105 MGFTFIFSTKSDLQIQP--WDQVPF-FLFIII--TVYTML---PFQMSYAVILSIISSLS----- 156

  Fly   259 LQMNSSSFCKMFPWHFI-MNEQLELVQLGRG---FSKLYKPYMADFGCQATTYFDFKRPKGLTMK 319
                          |.| ::..|.:.||...   |..|....:...|.....:......|.|...
Zfish   157 --------------HIIVLSVYLTVAQLHSNPITFQLLSNAVVFGCGIMVGIFHKVLMEKALKQT 207

  Fly   320 FRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLF 384
            |:|.:|                    .:|:.:|.::....:.|                    |.
Zfish   208 FQDTLR--------------------CLGIRMKLEIEKRQQEN--------------------LL 232

  Fly   385 ISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAE 449
            .|.:|::.:.:..:.:.|:.:.:|.            ||....|   |..|...|::
Zfish   233 QSVLPVYISMKMKLAIMERCKCKDK------------EEQQRMV---RDNNFHSLYV-------- 274

  Fly   450 KLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIG 514
                      |.:.:|:||::||||||.:.|..:|..::.||..|:..||:.....:..:::.:|
Zfish   275 ----------KRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKENECMRIKILG 329

  Fly   515 DAYCVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRY 579
            |.|...|||..:....|.....|.|.|.:|..:.....|..|.||:|:|:|.||.||:|.:..::
Zfish   330 DCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVREATGVDINMRVGVHSGNVLCGVIGLRKWQF 394

  Fly   580 CLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFE---------------------LQP 623
            .::.|.||:||..|||....:::::..|...|.|  .:|.|                     :.|
Zfish   395 DVWSHDVTLANHMESGGLPGRVHITEATLKHLNK--AYEVEEGNGHLRDTYLKELNIKTFLVIDP 457

  Fly   624 R--DPSFLPKEFPNP---------GGTETCYFLESF 648
            |  |.|.:......|         .......||||:
Zfish   458 RSKDSSLMAPSITKPRVSDGLKMRASVRMTRFLESW 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	27/143 (19%)
		HNOBA	259..451	CDD:285003	27/195 (14%)
		CYCc	430..619	CDD:214485	54/188 (29%)
		Guanylate_cyc	457..647	CDD:278633	60/221 (27%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	28/182 (15%)
		Guanylate_cyc	272..455	CDD:306677	54/202 (27%)
		DUF1053	487..613	CDD:310728	4/7 (57%)
		Guanylate_cyc	909..1106	CDD:306677

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810