DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and si:dkey-206f10.1

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_009293230.1	Gene:	si:dkey-206f10.1 / 560719	ZFINID:	ZDB-GENE-041014-154	Length:	1187	Species:	Danio rerio

Alignment Length:	874	Identity:	174/874 - (19%)
Similarity:	278/874 - (31%)	Gaps:	327/874 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GHWALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKS 88
            |...||.|....:.|.|:.|...:.|       ::.:.:||:            ..:||||.|..
Zfish   336 GRMKLETENQRQERLVLSILPRFVAL-------EMISDMTSM------------DDELDPQQFHK 381

  Fly    89 CANYDY------LADIQELLLKMDEASASEILVLLGE---------ELITC-----------CCT 127
            ...:.|      .|||:...|.....||.|::.||.|         |...|           |.:
Zfish   382 VYIHQYKDVSILFADIKGFTLLSMNMSAQELVRLLNELFGRFDRLAEEYDCLRIKILGDCYYCVS 446

  Fly   128 GIIE--RAF-RC--------------------------------------LGTDLQEF------- 144
            |:.|  ||. ||                                      ||....:|
Zfish   447 GVPEPQRAHARCCVEMGLAMISTMRSLRKQQNFDMDMRIGIHTGSVLCGVLGLQKWQFDVWSWDV 511

  Fly   145 ---------------------LGSLDGVYDVLKLQEED-------------VTDTGFVCAGEGEL 175
                                 |..|||.:     |.||             ..||..:|..|.:|
Zfish   512 GIANMLEAGGIPGRIHISRATLDCLDGSF-----QTEDGRGYERNEFLRKHNIDTFLICHKEDDL 571

  Fly   176 -IFTSERP------------VIAWLLLGSLKAL-----TRMLYKVDVNIKIEPVEGDARRYRYLF 222
             ...:|.|            ::|....||...|     .|.:.| ::|.:||... |.|
Zfish   572 NEMEAEHPKTRHNNRPWNKEILASFSNGSYTQLPTSSACRSMSK-EINKRIEHAI-DLR------ 628

  Fly   223 SLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGR 287
                 :|:.|.....|.|:....:.......|...|....::..|.     |||...|..||...
Zfish   629 -----SSERMRQEHITPVTLVFKDAHIEEKFSQVRDEMFKTNLVCS-----FIMLLLLMAVQALI 683

  Fly   288 GFSKLYKPYMADFGCQATTYF---------DFKRPKGLTMKF------RDIVRRTYTPFLIGLN- 336
            ...::|...:..|......|.         :||...|:..:|      .:.:|...|...|.:|
Zfish   684 PVPRMYLWTVLQFCLFLLGYLLLLVMVLAEEFKHSPGVLQQFCCWIHENNSMRNLLTITAIAMNF 748

  Fly   337 ------------------------------NPPGAVDFPAIGLEIKG--QMVHCP---------E 360
                                          .|..|..:|.: ..:.|  .||.|.         :
Zfish   749 GMALFDMMWCNSSEMKEISTRETEGYKAGQKPLTACTYPEV-FVLSGVVSMVTCAVFLRMSSLLK 812

  Fly   361 SNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQ---------------------- 403
            ...|||:.:.:           .:..::..|     ::.|.:|
Zfish   813 LTILLFVVAVY-----------TYFIEVSFH-----MLYVHQQEHEHLSRSHFLRRKGVSILLMA 861

  Fly   404 ----ARAQDGLR----RRMD-----KIKNSIEEANSAVTKERKKNVSLLHLIFPAEIA----EKL 451
                |...:|.|    .|:|     :.:..::|....    |:.|..|||.|.||.:|    |:.
Zfish   862 MFMIAVLYNGRRWEATTRLDFLWRLQAQQEVQEMRDL----REHNECLLHNILPAHVARHFLERN 922

  Fly   452 WLGSSIDAKTYPDVTILFSDIVGFTSI------------CSRATPFMVISMLEGLYKDFDEFCD- 503
            .....:.:::|.:|.::|:.|.||...            |        :.:|..:..||||..:
Zfish   923 RNDQELYSQSYDEVGVMFASIAGFNDYYEQKEIKHEGVEC--------LKLLNEIIADFDELLEE 979

  Fly   504 --FFDVYKVETIGDAYCVASGL----HRASIYDAH---KVAWMALKMIDACSKHITHDGEQIKMR 559
              |.|:.|::|||..|..||||    ....:.|.|   ::...||.|.:...:...|.....::|
Zfish   980 SYFLDIEKIKTIGSCYMAASGLSPDKQSRVVNDWHHLSELVLFALAMQETLREINKHSMNNFQLR 1044

  Fly   560 IGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTK----DWLTKHEGFEFE 620
            :|:..|.|:|||:|...|:|.::|.:|.:|::.:|...:.:|.|...|:    ||     ||..|
Zfish  1045 VGIAHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGVSGRIQVPEATRNILADW-----GFVLE 1104

  Fly   621 LQPRDPSFLPKEFPNPGGTETCYFLESFR 649
            |  |...::.......|...| ||:.:.|
Zfish  1105 L--RGEIYIKGVSERKGRVRT-YFISTKR 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	49/257 (19%)
		HNOBA	259..451	CDD:285003	47/287 (16%)
		CYCc	430..619	CDD:214485	60/218 (28%)
		Guanylate_cyc	457..647	CDD:278633	57/215 (27%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:292831	14/62 (23%)
		CYCc	343..538	CDD:214485	37/213 (17%)
		Guanylate_cyc	382..564	CDD:278633	32/186 (17%)
		DUF1053	<611..661	CDD:283888	13/62 (21%)
		CYCc	899..1097	CDD:214485	56/205 (27%)
		Guanylate_cyc	928..1126	CDD:278633	56/213 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810