Protein Alignment Gycalpha99B and ADCY10

DIOPT Version :9

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_060887.2
• Gene: ADCY10 / 55811
• HGNCID: 21285
• Length: 1610
• Species: Homo sapiens
• Alignment Length: 822
• Identity: 150/822 - (18%)
• Similarity: 259/822 - (31%)
• Gaps: 239/822 - (29%)

  Fly     7 RRADSLTRQPSVIAEPGGHWALEDEELSDDALTLTHLQMAIQLLTAPSN---EDLNTAVTSLVAK 68
            |.|.::.:...||..| ..|.|.|..:.:.........:.:..|..|.|   ::..|..|:.:..
Human   176 RLAQNMAQMNDVILSP-NCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHY 239

  Fly    69 YRQNWPNIHK--------LKLDPQTFKSCANY---------------DYLADIQEL------LLK 104
            |..   ..||        ||.||:...|...|               .||::::.:      |:.
Human   240 YPS---GEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMF 301

  Fly   105 MDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTG--F 167
            .|:..|.||             ...|:.|:..:.:.|:.|.|.::.|:         :.|.|  |
Human   302 EDQDKAEEI-------------GPAIQDAYMHITSVLKIFQGQINKVF---------MFDKGCSF 344

  Fly   168 VCA----GE---GELIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLV 225
            :|.    ||   .||....|..:..:.....:..:..:...|...|....:.|...|:.|.....
Human   345 LCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQ 409

  Fly   226 KDN-SQTMLMGRPTSVS----------------KTIPETVQRSNSSNASDLQMNSSSFCKMFPWH 273
            |.| :..|:|..|..|:                |.:|:.|.:..:.:....|....:...||...
Human   410 KVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMA 474

  Fly   274 -FIMNEQLELVQLGRG-----FSKLYKPYMADFGCQATTYFDFKRPKGL--------TMKFRDIV 324
             .|.|.:.:...|||.     |....|.::.....|...|      :||        .||...:.
Human   475 CLICNRKEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMY------EGLPGYGKSQILMKIEYLA 533

  Fly   325 R-RTYTPFLIGLNNPPGAVDF------------PAIGLE------------------IKGQMVHC 358
            : :.:....|.||.    :.|            ..:||:                  :..:..:|
Human   534 QGKNHRIIAISLNK----ISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYC 594

  Fly   359 PESNSLLFIGSPFLDGLDGLT-------CNGLFISDIPLHDATREVILVGEQARAQDGLR-RRMD 415
             ..|.:..:..|....:..::       ...||:..:.|......:|.:.::|:..|... |.|:
Human   595 -LLNDIFHVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFME 658

  Fly   416 KIKNSIE---------------EANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDV 465
            |:..::.               .|..||.|.|.....::..:.|.:|:.|:.|..        :|
Human   659 KLIRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDL--------NV 715

  Fly   466 TILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYD 530
            :.:..::..:....|...||....:|:.|  :..|...|......|.....:   :.|.:.||..
Human   716 SCISKELDSYLGEGSCGIPFYCEELLKNL--EHHEVLVFQQTESEEKTNRTW---NNLFKYSIKL 775

  Fly   531 AHKVAWMALKMIDACSKHITH--DGEQIK------------------MRIGLHTGTVLAGVVGRK 575
            ..|:..:.|.. |..|:.:.|  .|.::|                  ||:........|.::|..
Human   776 TEKLNMVTLHS-DKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLT 839

  Fly   576 MPRYCLFG---------HSVTIANKFES--------GSE---ALKINVSPTTKDWLTKHEGFEFE 620
            .....||.         ...|:|...||        |.|   |||.| .|:            ||
Human   840 FTTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQN-DPS------------FE 891

  Fly   621 LQPRDPSFLPKEFPNPGGTETCYFLES---------FRNPAL 653
            :..|..|..|.|..:.|..|....||:         |.||.:
Human   892 VHYRSLSLKPSEGMDHGEEEQLRELENEVIECHRIRFCNPMM 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	32/169 (19%)
		HNOBA	259..451	CDD:285003	41/259 (16%)
		CYCc	430..619	CDD:214485	42/228 (18%)
		Guanylate_cyc	457..647	CDD:278633	45/229 (20%)
ADCY10	NP_060887.2	CHD	40..214	CDD:143636	8/38 (21%)
		AcyC	<42..197	CDD:225025	6/21 (29%)
		CHD	292..461	CDD:143636	34/190 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900