DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and gucy1b2

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	718	Identity:	196/718 - (27%)
Similarity:	320/718 - (44%)	Gaps:	121/718 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LNTAVTSLVAKY--RQNWPNIHKLKLDPQTFKSCANYDYLADIQELLL-----KMDEASASEILV 115
            :||.:.|||.:.  .:.|.|:..:....:||.:...||   ||..|.|     ||.:.|:..:|.
Zfish     5 INTCLKSLVIERFGEETWENLRLMAGVQETFMTYEIYD---DIITLRLVQEACKMLDVSSEVVLK 66

  Fly   116 LLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVC--AGEGELI-- 176
            |.||...:.|.....:...|.||.:|.||:.:||.::..|.|..|.:....|..  ..:|.::
Zfish    67 LFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYEAMNAPSFRVERMDDGRILLH 131

  Fly   177 FTSERPVIAWLLLGSLKALTRMLYKVDVNIKI----EPVEGDARRYRYLFSLV------------ 225
            :.|:|..:..::.|.::|:.:..:..:|.:.|    |..|...::...:|.:|
Zfish   132 YYSDRKGLYHIVPGIIEAVAKDFFDSEVTMTILNQSEEDERTGKKEHVVFHMVQKEKVTKRKAQT 196

  Fly   226 -KDNSQTMLMGRPTSVSKTIPETVQRSNSSNAS-------------------------------- 257
             ::||:..::    .|.|...||::|..:..|:
Zfish   197 RQNNSEEEIL----EVKKDKEETMRRMKARYANLQLCPRKRSPWELVRSIVMLGQGNLRQSFTPS 257

  Fly   258 ---DLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRP------ 313
               .|.:...:||..||:|.:.:..|.:...|....| :.|.:...|.:...||....|
Zfish   258 YPKTLWIEEQAFCNAFPFHIVFDSDLVVKHTGVNIQK-FVPGLQTAGIRLDEYFTIVHPEVIFNI 321

  Fly   314 ----KGLTMKFRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDG 374
                |.:..:|....||...| .:..|.|.         |:::|||:.....|.::::.||.|..
Zfish   322 QSIKKFINSQFVLKTRREMLP-EVQQNQPT---------LKLRGQMMWMESLNCMIYLCSPKLRS 376

  Fly   375 LDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLL 439
            |..|...||.::||..||.||::||:.:|..|:..|..::::.|..:...:..:..|::|:..||
Zfish   377 LQELEERGLHLADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELRILSRNLEIEKQKSEKLL 441

  Fly   440 HLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDF 504
            :.:.|..:|.:|..|..::|..:...||||||:|.||:||:...|..:::||..:|..||.....
Zfish   442 YAMLPTHVANQLKEGKRVEAGEFKVCTILFSDVVTFTNICAACEPIQIVNMLNAMYSRFDRLTSI 506

  Fly   505 FDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDACSKHITH--DGEQIKMRIGLHTGTV 567
            .:|||||||||||.|..|:...:...|.:||..||.|..| ::.:|:  .|:.|::|:|||||.|
Zfish   507 HNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALGMRIA-AREVTNPITGQPIQIRVGLHTGPV 570

  Fly   568 LAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRD------- 625
            ||||||.|||||||||.:|..|::.||......|:|||.|.. :.|.:|. ||:..|.
Zfish   571 LAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFS-VIKDKGI-FEMAERGEIEVKGK 633

  Fly   626 ----PSFLPKEFPNPG-------GTETCYFLESFRNPALDSELPLVEHINVSMKT-------ISE 672
                ..||.|......       ..|.|.:.|.......|.:....|.:|..:|.       ::|
Zfish   634 GLMRTYFLLKNLQKSDEQIMGLVDGEMCVYQEDLEEETDDLKEVSPEDMNAVLKVEEDAHKEVAE 698

  Fly   673 GGD 675
            .|:
Zfish   699 NGN 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	34/140 (24%)
		HNOBA	259..451	CDD:285003	51/201 (25%)
		CYCc	430..619	CDD:214485	82/190 (43%)
		Guanylate_cyc	457..647	CDD:278633	82/209 (39%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002	41/160 (26%)
		CAF-1_p150	<166..277	CDD:288454	17/114 (15%)
		HNOBA	269..453	CDD:285003	50/194 (26%)
		CYCc	432..618	CDD:214485	81/187 (43%)
		Guanylate_cyc	459..642	CDD:278633	78/185 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820