DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and npr1b

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	690	Identity:	183/690 - (26%)
Similarity:	290/690 - (42%)	Gaps:	191/690 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DLNTAVTSLVAKYRQ-------------NWPNIHKLKLDPQT--FK----SC-----ANYDYLAD 97
            |:||....:||.|..             .||. .|:.:|..|  ||    :|     |.:..::.
Zfish   424 DINTGDFQIVAVYNGTQKEMNILPGMAIQWPG-GKVPMDVPTCGFKNENPACRARTIAMHQMISI 487

  Fly    98 IQELL--------------LKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFL--- 145
            :..|:              ||:::...:::..:..:::    ....:|:|.|..|:.|...|
Zfish   488 VLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDI----QMSHLEKALRSTGSKLTLSLRGS 548

  Fly   146 --GSL---DGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVN 205
              |||   ||.:.|.       ..||:.   :|.::              ::|.:.|.  :|::.
Zfish   549 NYGSLLTTDGNFQVF-------AKTGYF---KGNIV--------------AIKYINRR--RVELT 587

  Fly   206 IKIEPVEGDARRYRYLFSL-----VKDNSQTMLMGR---PTSVSKTIPETVQRSNSSNASDLQMN 262
            .|:            ||.|     |::...|..:|.   |.::. .:.|...|.:..|.  |:.:
Zfish   588 RKV------------LFELKHMRDVQNEHLTRFIGACIDPPNIC-IVTEYCPRGSLQNI--LEND 637

  Fly   263 SSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPY---------------------MADFGC---- 302
            |.:...||.:..|.:       :.:|.:.|:...                     :.|:|.
Zfish   638 SITLDWMFKYSLISD-------IVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIR 695

  Fly   303 ------QATTYFDFKR------------PKGLTMK---------FRDIVRRTYTPFLIG-LNNPP 339
                  .|.:|:..|.            |.|.|.|         .:::..|....:|.| |.:|.
Zfish   696 TESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDLLSPK 760

  Fly   340 GAVDFPAIG-----LEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVIL 399
            ..||..|:|     ........|..|...|:            ..|.....||.|  :.:...:|
Zfish   761 EIVDRVALGEWPYLRPSLNPQAHSEELGQLM------------QRCWAEEPSDRP--EFSHISVL 811

  Fly   400 VGEQARAQ-----DGLRRRMDKIKNS----IEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGS 455
            :.:|.|..     |.|..||::..|:    :||...|..:|::|..:||:.|.|..:||:|..|.
Zfish   812 LRKQNREHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGE 876

  Fly   456 SIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVA 520
            ::.|:.:..|||.|||||||||:.:.:||..|:::|..||..||...|.|||||||||||||.|.
Zfish   877 TVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVV 941

  Fly   521 SGLH-RASIYDAHKVAWMALKMIDACSK-HITH-DGEQIKMRIGLHTGTVLAGVVGRKMPRYCLF 582
            |||. |.......::|.|:|.:::|... .|.| ..||:|:|||:|:|.|.|||||.||||||||
Zfish   942 SGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLF 1006

  Fly   583 GHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQ 622
            |.:|..:::.||..|.|||:||..|:..|.:...|:.||:
Zfish  1007 GDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELR 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	28/164 (17%)
		HNOBA	259..451	CDD:285003	51/258 (20%)
		CYCc	430..619	CDD:214485	91/191 (48%)
		Guanylate_cyc	457..647	CDD:278633	83/169 (49%)
npr1b	XP_009290669.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810