Protein Alignment Gycalpha99B and npr1b

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: XP_009290669.2
• Gene: npr1b / 555911
• ZFINID: ZDB-GENE-100805-4
• Length: 1070
• Species: Danio rerio
• Alignment Length: 690
• Identity: 183/690 - (26%)
• Similarity: 290/690 - (42%)
• Gaps: 191/690 - (27%)

  Fly    57 DLNTAVTSLVAKYRQ-------------NWPNIHKLKLDPQT--FK----SC-----ANYDYLAD 97
            |:||....:||.|..             .||. .|:.:|..|  ||    :|     |.:..::.
Zfish   424 DINTGDFQIVAVYNGTQKEMNILPGMAIQWPG-GKVPMDVPTCGFKNENPACRARTIAMHQMISI 487

  Fly    98 IQELL--------------LKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFL--- 145
            :..|:              ||:::...:::..:..:::    ....:|:|.|..|:.|...|
Zfish   488 VLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDI----QMSHLEKALRSTGSKLTLSLRGS 548

  Fly   146 --GSL---DGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVN 205
              |||   ||.:.|.       ..||:.   :|.::              ::|.:.|.  :|::.
Zfish   549 NYGSLLTTDGNFQVF-------AKTGYF---KGNIV--------------AIKYINRR--RVELT 587

  Fly   206 IKIEPVEGDARRYRYLFSL-----VKDNSQTMLMGR---PTSVSKTIPETVQRSNSSNASDLQMN 262
            .|:            ||.|     |::...|..:|.   |.::. .:.|...|.:..|.  |:.:
Zfish   588 RKV------------LFELKHMRDVQNEHLTRFIGACIDPPNIC-IVTEYCPRGSLQNI--LEND 637

  Fly   263 SSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPY---------------------MADFGC---- 302
            |.:...||.:..|.:       :.:|.:.|:...                     :.|:|.
Zfish   638 SITLDWMFKYSLISD-------IVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIR 695

  Fly   303 ------QATTYFDFKR------------PKGLTMK---------FRDIVRRTYTPFLIG-LNNPP 339
                  .|.:|:..|.            |.|.|.|         .:::..|....:|.| |.:|.
Zfish   696 TESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDLLSPK 760

  Fly   340 GAVDFPAIG-----LEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVIL 399
            ..||..|:|     ........|..|...|:            ..|.....||.|  :.:...:|
Zfish   761 EIVDRVALGEWPYLRPSLNPQAHSEELGQLM------------QRCWAEEPSDRP--EFSHISVL 811

  Fly   400 VGEQARAQ-----DGLRRRMDKIKNS----IEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGS 455
            :.:|.|..     |.|..||::..|:    :||...|..:|::|..:||:.|.|..:||:|..|.
Zfish   812 LRKQNREHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGE 876

  Fly   456 SIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVA 520
            ::.|:.:..|||.|||||||||:.:.:||..|:::|..||..||...|.|||||||||||||.|.
Zfish   877 TVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVV 941

  Fly   521 SGLH-RASIYDAHKVAWMALKMIDACSK-HITH-DGEQIKMRIGLHTGTVLAGVVGRKMPRYCLF 582
            |||. |.......::|.|:|.:::|... .|.| ..||:|:|||:|:|.|.|||||.||||||||
Zfish   942 SGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLF 1006

  Fly   583 GHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQ 622
            |.:|..:::.||..|.|||:||..|:..|.:...|:.||:
Zfish  1007 GDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELR 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	18/106 (17%)
		HNOBA	259..451	CDD:462234	51/258 (20%)
		Guanylate_cyc	457..647	CDD:425528	83/169 (49%)
npr1b	XP_009290669.2	Periplasmic_Binding_Protein_type1	50..453	CDD:471960	6/28 (21%)
		PK_GC-A_B	544..818	CDD:270944	58/335 (17%)
		HNOBA	<818..872	CDD:462234	16/53 (30%)
		CYCc	851..1036	CDD:214485	89/184 (48%)