DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and Phlpp2

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	89/405 - (21%)
Similarity:	151/405 - (37%)	Gaps:	88/405 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQ---EFLGSLDGVYDVLKLQEEDV 162
            |:|...|..||||....|.|.:.....|.:.|........||   ::|..| |..|.:::||| .
  Rat   100 LVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRL-GFEDPVRIQEE-A 162

  Fly   163 TDTGFVC---------------------------AGEGELIFTSERPVI---AWLLLGSLK-ALT 196
            |:....|                           .|:.:|...:||.|:   ..|::.|:| ..|
  Rat   163 TNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQT 227

  Fly   197 RMLYKVD-VNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRPT---------SVSKTIPETVQRS 251
            ..::.:. |..|||.|:  .|::...||.....:||..:...|         ..||.:.:.:
  Rat   228 GKMHILPLVGGKIEEVK--RRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRI--- 287

  Fly   252 NSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGL 316
               :..||...|   .:..|.|...::.:..:.|...|.:|.:|...|      |.:.|.:.|||
  Rat   288 ---STVDLSCYS---LEEVPEHLFYSQDITYLNLRHNFMQLERPGGLD------TLYKFSQLKGL 340

  Fly   317 TMKFRDI--------VRRTYTPFLIGLNNPPGAVDFPA-IGLEIKGQMVHCPESNSLLFIGSPFL 372
            .:....:        ...|.|...:..|   |..|.|: ||..:..|.: |.:.|.|..:... |
  Rat   341 NLSHNKLGLFPVLLCEISTLTELNLSCN---GFHDLPSQIGNLLNLQTL-CLDGNVLTALPDE-L 400

  Fly   373 DGLDGLTCNGLF---ISDIP--LHDATR--EVILVGEQARAQD-GLRRRMDKIKN---SIEEANS 426
            ..|..||..|:.   .|.||  |...|.  :|::.|.:....: |:..||:.:|:   .:....:
  Rat   401 GNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVDLRMNHLKT 465

  Fly   427 AVTKERKKNVSLLHL 441
            .:.:..:.|..:.|:
  Rat   466 VIIENLEGNKHITHM 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	32/141 (23%)
		HNOBA	259..451	CDD:285003	44/203 (22%)
		CYCc	430..619	CDD:214485	2/12 (17%)
		Guanylate_cyc	457..647	CDD:278633
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761	22/79 (28%)
		PH_PHLPP-like	185..279	CDD:270131	20/95 (21%)
		PLN00113	284..>762	CDD:215061	45/217 (21%)
		leucine-rich repeat	289..309	CDD:275380	5/22 (23%)
		leucine-rich repeat	310..336	CDD:275380	7/31 (23%)
		leucine-rich repeat	337..359	CDD:275380	3/21 (14%)
		leucine-rich repeat	360..382	CDD:275380	7/24 (29%)
		leucine-rich repeat	383..405	CDD:275380	6/23 (26%)
		leucine-rich repeat	406..428	CDD:275380	7/21 (33%)
		leucine-rich repeat	429..452	CDD:275380	5/22 (23%)
		leucine-rich repeat	453..476	CDD:275380	2/22 (9%)
		leucine-rich repeat	477..497	CDD:275380	1/4 (25%)
		leucine-rich repeat	498..517	CDD:275380
		leucine-rich repeat	518..539	CDD:275380
		leucine-rich repeat	540..562	CDD:275380
		leucine-rich repeat	563..584	CDD:275380
		leucine-rich repeat	586..607	CDD:275380
		leucine-rich repeat	608..631	CDD:275380
		leucine-rich repeat	632..681	CDD:275380
		leucine-rich repeat	682..705	CDD:275380
		leucine-rich repeat	706..728	CDD:275380
		leucine-rich repeat	751..772	CDD:275380
		PP2Cc	820..1069	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900