Protein Alignment Gycalpha99B and NPR1

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 185/662 - (27%)
• Similarity: 279/662 - (42%)
• Gaps: 167/662 - (25%)

  Fly    66 VAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELLLKMDEASASEILVLLGEELITCCCTGII 130
            |:..:.|||    |...|.....|.     .|.::.....|..|..|:|.|:|    :....||:
Human   436 VSGRKLNWP----LGYPPPDIPKCG-----FDNEDPACNQDHLSTLEVLALVG----SLSLLGIL 487

  Fly   131 ERAF---RCLGTDLQEFLGSLDGVYDVLKLQEEDV----------------------TDTGFVCA 170
            ..:|   |.:  .|::.|.|     ::.:::.|||                      ::.|.:..
Human   488 IVSFFIYRKM--QLEKELAS-----ELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLT 545

  Fly   171 GEGEL-IFTSERPVIAWLLLGSLKALTRMLYK-VDVNIKIEPVEGDARRYRYLFSL-----VKDN 228
            .||:. :|....     ...|:|.|:.|:..| :::..|:            ||.|     |::.
Human   546 TEGQFQVFAKTA-----YYKGNLVAVKRVNRKRIELTRKV------------LFELKHMRDVQNE 593

  Fly   229 SQTMLMGRPTSVSKTIPETV----QRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGF 289
            ..|..:|..|.     |..:    :.....:..|:..|.|.   ...|.|..:...::|   :|.
Human   594 HLTRFVGACTD-----PPNICILTEYCPRGSLQDILENESI---TLDWMFRYSLTNDIV---KGM 647

  Fly   290 SKLYKPYMADFG------CQATTYFDFKRPKGLTMKFRDI---------VRRTYT-PFLIGLNNP 338
            ..|:...:...|      |.....|..|........|||:         .::.:| |.|:.:.:|
Human   648 LFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASP 712

  Fly   339 P----GAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLD----------------------- 376
            |    .|.|..:.|:.::         ...|..|...::|||
Human   713 PVRGSQAGDVYSFGIILQ---------EIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLA 768

  Fly   377 --------GLTCNGLFISD-----------IPLHDATREVILVGEQARAQDGLRRRMDKIKNS-- 420
                    ||.....:..|           :.|....||     ..:...|.|..||::..|:
Human   769 LQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-----NSSNILDNLLSRMEQYANNLE 828

  Fly   421 --IEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRAT 483
              :||...|..:|::|..:||:.|.|..:||:|..|.::.|:.:..|||.||||||||::.:.:|
Human   829 ELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAEST 893

  Fly   484 PFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLH-RASIYDAHKVAWMALKMIDAC-S 546
            |..|:::|..||..||...|.|||||||||||||.|.|||. |.....|.:||.|||.::||. |
Human   894 PMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRS 958

  Fly   547 KHITH-DGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDW 610
            ..|.| ..||:::|||:|||.|.|||||.|||||||||.:|..|::.||..|||||::|..||..
Human   959 FRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAV 1023

  Fly   611 LTKHEGFEFELQ 622
            |.:..|||.||:
Human  1024 LEEFGGFELELR 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	24/125 (19%)
		HNOBA	259..451	CDD:462234	49/257 (19%)
		Guanylate_cyc	457..647	CDD:425528	91/169 (54%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:380608	1/6 (17%)
		PK_GC-A_B	534..807	CDD:270944	50/309 (16%)
		HNOBA	<813..861	CDD:462234	16/47 (34%)
		CYCc	840..1032	CDD:214485	98/191 (51%)