DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Ac78C

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	149/759 - (19%)
Similarity:	270/759 - (35%)	Gaps:	192/759 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DSLTRQPSVIAEPGGHW----ALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYR 70
            |.|.|..|::.:.....    |:.|||:.:      .::..||:   .||:::.       .:|.
  Fly   949 DGLNRADSILVDTKEDHRVSVAVLDEEIDE------FIEQNIQI---NSNKEIR-------REYL 997

  Fly    71 QNWPNIHKLKLDPQTF-----------KSCANYDYLADIQELLLKMDEASASEILVLLGEELITC 124
            ..|....|.|...|.|           ..|....::..:...::.:...:...|.:.:|..::|.
  Fly   998 NPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTF 1062

  Fly   125 CCTGIIERAF----RCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIA 185
            ||..::...|    |||.|             :..||..:....|.|:|   |.::.......|.
  Fly  1063 CCVLVMAEEFPGLPRCLKT-------------NSAKLVHQRQRRTLFIC---GVIVSMCMLSAIG 1111

  Fly   186 WLL------LGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDN--SQTMLMGRPT---- 238
            .:|      :|:....:|.|..|.....|...|.:.:...||.:.:..|  ..|...|.||
  Fly  1112 LVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVD 1176

  Fly   239 --------------------SVSKTIPE------------TVQRSNSSNASDLQMNSSSFCK--- 268
                                :::..:|:            :|..||.|.:....|.|||..:
  Fly  1177 ITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQC 1241

  Fly   269 MFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLI 333
            ..|.:.:....|.||.|.... |||....|........::...    :.|||
  Fly  1242 AHPEYLVFTWVLCLVSLATAL-KLYYLVKALMALAMVAFYTTL----IMMKF------------- 1288

  Fly   334 GLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVI 398
            |..:....|:...:|:.:..||:       :|.|.  ||                         :
  Fly  1289 GSGDSFSLVELSRLGMPLGVQML-------ILLIS--FL-------------------------V 1319

  Fly   399 LVGEQARAQDGLRRRMDKI-KNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSID---A 459
            :|...||..: :..|:|.| |...|...:.:...|..|.:|:..|.|..:|.........|   :
  Fly  1320 MVCYHARLVE-VTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYS 1383

  Fly   460 KTYPDVTILFSDIVGFTSICS------RATPFMVISMLEGLYKDFDEFCD---FFDVYKVETIGD 515
            |.:....::|:.|..|....|      :|    .|.:|..:..||||..:   |..|.|::|:|.
  Fly  1384 KMHNLCGVMFASIPNFQDFYSEDIDNGKA----CIRILNEIICDFDELLEEPRFASVEKIKTVGA 1444

  Fly   516 AYCVASGLHRA-----------SIYDAHKVAWMALKMIDACSKHITHDG-EQIKMRIGLHTGTVL 568
            .|..|:||:..           |:.|..:.|:...:.::    .|..|. ...::|:|:.:|.::
  Fly  1445 TYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLE----EINGDAFNNFQLRVGICSGPLV 1505

  Fly   569 AGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGF----EFELQPRDPSFL 629
            :||:|.:.|.|.::|::|.:|::.:|..|..::.|...|.:.|.. .|:    ..|:..:....:
  Fly  1506 SGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCS-RGYTCVKRGEIAVKGKGMM 1569

  Fly   630 PKEFPNPGGTETCYFLESFRNPALDSELPLVEHINVSMKTISEG 673
            ...:.:|.|......:...|.||   .:||.:..|:..:|...|
  Fly  1570 TTFYVHPKGISESQLISPVRMPA---GIPLAQTPNLQRQTSHHG 1610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	27/152 (18%)
		HNOBA	259..451	CDD:285003	39/195 (20%)
		CYCc	430..619	CDD:214485	50/216 (23%)
		Guanylate_cyc	457..647	CDD:278633	47/217 (22%)
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831
		CYCc	526..729	CDD:214485
		Guanylate_cyc	566..753	CDD:278633
		DUF1053	929..1020	CDD:283888	18/86 (21%)
		CYCc	1353..1554	CDD:214485	50/209 (24%)
		Guanylate_cyc	1381..1576	CDD:278633	44/203 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810