DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gycalpha99B and GUCY1A2

DIOPT Version :9

Sequence 1:NP_477088.2 Gene:Gycalpha99B / 43493 FlyBaseID:FBgn0013972 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_001243353.1 Gene:GUCY1A2 / 2977 HGNCID:4684 Length:763 Species:Homo sapiens


Alignment Length:684 Identity:256/684 - (37%)
Similarity:368/684 - (53%) Gaps:104/684 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 LTLTHLQMAIQLLTAPSNEDLNTAVTSL-------VAKYRQNWPNIHKLKLDPQTFKSCANYDYL 95
            :.|..|..:|..|||||.:.:...:...       |..||....|.|.:. :..::...:|.:.:
Human    85 VNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNIS-NRCSYADHSNKEEI 148

  Fly    96 ADIQELL--------LKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVY 152
            .|:..:|        ||.:     ||....|||....|... .||..|.:|..||:|....|.:.
Human   149 EDVSGILQCTANILGLKFE-----EIQKRFGEEFFNICFHE-NERVLRAVGGTLQDFFNGFDALL 207

  Fly   153 DVLKL---QEEDVTDTGFVC--AGEGELIFTSERP--VIAWLLLGSLKALTRMLYKVDVNIKIEP 210
            :.::.   ::..:....|:|  ..||.|:.....|  ::.:.:||.:||..:.:|::||  ::|.
Human   208 EHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDV--EVEQ 270

  Fly   211 VEGDARRYRYLFSLVKDNSQ-------TMLMG--RPTSVSKTIPETVQRSNSSNASDLQMNSSSF 266
            |..:        .|..|.|.       |.|:.  ..|::.|.:|:    ..|...:||:::.::|
Human   271 VANE--------KLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQ----GTSQVPADLRISINTF 323

  Fly   267 CKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQA------TTYFDFKRPKGLTMKFRDIVR 325
            |:.||:|.:.:..:.::|||.|..|..:       |..      ...|:...|| :...|..::.
Human   324 CRAFPFHLMFDPSMSVLQLGEGLRKQLR-------CDTHKVLKFEDCFEIVSPK-VNATFERVLL 380

  Fly   326 RTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPL 390
            |..|||:|.........:.....:|:||||:|.|||||:||:|||.:|.||.|...||.:||||:
Human   381 RLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPI 445

  Fly   391 HDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGS 455
            |||||:||||||||:|||||::||||:|.::|..:.|:.:|:||.|.||:.|||.::|::||.|.
Human   446 HDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQ 510

  Fly   456 SIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVA 520
            .:.|:.:.|||:|||||||||:||::.||..|||||..||..||..|.|.|:|||||||||||||
Human   511 QVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVA 575

  Fly   521 SGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQI----------------------------- 556
            :||||.|:..|..:|.|||||::...:.:|.||..|                             
Human   576 AGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLG 640

  Fly   557 --KMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEF 619
              |||||:|:|:|||||||.:||||||||::||:|:||||||...:|||||||...|.:.|.|.|
Human   641 TEKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTF 705

  Fly   620 ELQPRDPSFLPKEFPN--PGGTETCYFLESFRNP 651
              .||....||..||.  ||   .|||||....|
Human   706 --IPRSREELPDNFPKEIPG---ICYFLEVRTGP 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gycalpha99BNP_477088.2 HNOB 76..208 CDD:285002 33/146 (23%)
HNOBA 259..451 CDD:285003 82/197 (42%)
CYCc 430..619 CDD:214485 112/219 (51%)
Guanylate_cyc 457..647 CDD:278633 112/222 (50%)
GUCY1A2NP_001243353.1 HNOB <159..270 CDD:285002 29/118 (25%)
HNOBA 316..503 CDD:285003 81/194 (42%)
CYCc 485..705 CDD:214485 112/219 (51%)
Guanylate_cyc 514..729 CDD:278633 111/219 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 205 1.000 Domainoid score I2928
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H47953
Inparanoid 1 1.050 411 1.000 Inparanoid score I1865
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D245586at33208
OrthoFinder 1 1.000 - - FOG0008257
OrthoInspector 1 1.000 - - otm41877
orthoMCL 1 0.900 - - OOG6_106420
Panther 1 1.100 - - O PTHR45655
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4585
SonicParanoid 1 1.000 - - X3073
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.860

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