DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Adcy8

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_058838.1	Gene:	Adcy8 / 29241	RGDID:	2036	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	89/328 - (27%)
Similarity:	131/328 - (39%)	Gaps:	85/328 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 GLFISDIPLHD-ATREVILVGEQARAQDGLRR------RMDKIKNSI-------EEANSAVTKER 432
            |:|||  .|.| |.|:..|  |..|..:...|      |.:::..|:       |..|.....|.
  Rat   332 GIFIS--YLSDRAQRQAFL--ETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVED 392

  Fly   433 KKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKD 497
            :......|.|:               ...|.:|:|||:|:.|||::.:..:...::.||..|:..
  Rat   393 EHLQHQFHRIY---------------IHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFAR 442

  Fly   498 FDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDAC------SKHITHDGEQI 556
            ||.........:::.:||.|...|||.......||....|.|.||...      :||      .:
  Rat   443 FDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKH------DV 501

  Fly   557 KMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKD------------ 609
            .||||:|:|:||.||:|.:..::.::...|.||||.|||....:|::|..|.|
  Rat   502 DMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGH 566

  Fly   610 ------WLTKHEGFEFEL--QPRD-----PSFLPKEF------PNPGGTETCYFLESFRNPALDS 655
                  :|.|| ..|..|  ||.:     |..:.||.      .|.|.|    |.|...:|
  Rat   567 GKERNEFLRKH-NIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGAT----FTEGSWSP---- 622

  Fly   656 ELP 658
            |||
  Rat   623 ELP 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	19/82 (23%)
		CYCc	430..619	CDD:214485	57/212 (27%)
		Guanylate_cyc	457..647	CDD:278633	65/226 (29%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269\|PubMed:16258073, ECO:0000269\|PubMed:22494970, ECO:0000269\|PubMed:22976297	1..179
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269\|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..117
		AC_N	<158..397	CDD:292831	17/68 (25%)
		CYCc	363..561	CDD:214485	58/218 (27%)
		Guanylate_cyc	402..586	CDD:278633	57/205 (28%)
		DUF1053	614..708	CDD:283888	7/20 (35%)
		CYCc	941..1145	CDD:214485
		Guanylate_cyc	970..1169	CDD:278633
		Involved in CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	1106..1248
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269\|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1220..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900