DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gycalpha99B and Adcy8

DIOPT Version :10

Sequence 1:NP_477088.2 Gene:Gycalpha99B / 43493 FlyBaseID:FBgn0013972 Length:676 Species:Drosophila melanogaster
Sequence 2:NP_058838.1 Gene:Adcy8 / 29241 RGDID:2036 Length:1248 Species:Rattus norvegicus


Alignment Length:328 Identity:89/328 - (27%)
Similarity:131/328 - (39%) Gaps:85/328 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   382 GLFISDIPLHD-ATREVILVGEQARAQDGLRR------RMDKIKNSI-------EEANSAVTKER 432
            |:|||  .|.| |.|:..|  |..|..:...|      |.:::..|:       |..|.....|.
  Rat   332 GIFIS--YLSDRAQRQAFL--ETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVED 392

  Fly   433 KKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKD 497
            :......|.|:               ...|.:|:|||:|:.|||::.:..:...::.||..|:..
  Rat   393 EHLQHQFHRIY---------------IHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFAR 442

  Fly   498 FDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDAC------SKHITHDGEQI 556
            ||.........:::.:||.|...|||.......||....|.|.||...      :||      .:
  Rat   443 FDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKH------DV 501

  Fly   557 KMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKD------------ 609
            .||||:|:|:||.||:|.:..::.::...|.||||.|||....:|::|..|.|            
  Rat   502 DMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGH 566

  Fly   610 ------WLTKHEGFEFEL--QPRD-----PSFLPKEF------PNPGGTETCYFLESFRNPALDS 655
                  :|.|| ..|..|  ||.:     |..:.||.      .|.|.|    |.|...:|    
  Rat   567 GKERNEFLRKH-NIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGAT----FTEGSWSP---- 622

  Fly   656 ELP 658
            |||
  Rat   623 ELP 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gycalpha99BNP_477088.2 HNOB <109..208 CDD:462233
HNOBA 259..451 CDD:462234 19/82 (23%)
Guanylate_cyc 457..647 CDD:425528 65/226 (29%)
Adcy8NP_058838.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297 1..179
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297 1..106
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 38..40
Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..117
AcyC 211..564 CDD:441717 70/256 (27%)
Guanylate_cyc 402..586 CDD:425528 57/205 (28%)
Adcy_cons_dom 614..709 CDD:461877 7/20 (35%)
Guanylate_cyc 970..1169 CDD:425528
Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073 1106..1248
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019 1197..1212
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1248
Blue background indicates that the domain is not in the aligned region.

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