Protein Alignment Gycalpha99B and Gucy1b2

DIOPT Version :9

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001257640.1
• Gene: Gucy1b2 / 25206
• RGDID: 2770
• Length: 742
• Species: Rattus norvegicus
• Alignment Length: 658
• Identity: 194/658 - (29%)
• Similarity: 305/658 - (46%)
• Gaps: 92/658 - (13%)

  Fly    58 LNTAVTSLVAKY--RQNWPNIHKLKLDPQ---TFKSCANYDYLADIQ--ELLLKMDEASASEILV 115
            :||.:.|||.:.  .:.|   .|||...:   .|.:...||.:..|:  :...|:.:.|...||.
  Rat     5 INTCLQSLVTEKFGEETW---EKLKASAEVQDVFMTYTVYDDIITIKLIQEACKVLDVSMEAILK 66

  Fly   116 LLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVC--AGEGELI-- 176
            |.||.....|.....:|..|.||.:|.||:.:||.::..|.|..:::....|..  ..:|.::
  Rat    67 LFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEEGADGAMLLH 131

  Fly   177 FTSERPVIAWLLLGSLKALTRMLYKVDVNIKI----EPVEGDARRYRYLFSLVKDNSQTMLMG-- 235
            :.|:|..:..::.|.::|:.:..:..||.:.|    |.||...::...:| ||...:...:.|
  Rat   132 YYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVF-LVVQKAHRQIRGAK 195

  Fly   236 --RP--TSVSKTIPETVQ---------------------RSNSSNAS------------------ 257
              ||  :..|:...|.:|                     .|.:..||
  Rat   196 ASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLRDTFQPVYPE 260

  Fly   258 DLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRD 322
            .|.:....||..||:|.:.:|.|.:.|.|....| |.|.:.........||....|: :|.....
  Rat   261 RLWVEEEVFCDAFPFHIVFDEALRVKQAGVNIQK-YVPGILTQKFALDEYFSIIHPQ-VTFNISS 323

  Fly   323 IVRRTYTPFLIGLNN---PPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLF 384
            |.:...:.|::....   |......|.  |:::|||:.......::|:.||.|..|..|..:.:.
  Rat   324 ICKFINSQFVLKTRKEMMPKARKSQPM--LKLRGQMIWMESLRCMIFMCSPKLRSLQELEESKMH 386

  Fly   385 ISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAE 449
            :|||..||.||::||:.:|..|:..|..:::|.|..:...::.:..|:||..:||:.:.|..:|.
  Rat   387 LSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVAN 451

  Fly   450 KLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIG 514
            :|..|..:.|..:...||||||:|.||:||:...|..:::||..:|..||......|||||||||
  Rat   452 QLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIG 516

  Fly   515 DAYCVASGLHRASIYDAHKVAWMALKM-IDACSKHITH--DGEQIKMRIGLHTGTVLAGVVGRKM 576
            |||.|..|:.......|.:||..||.| |.|  |.:.:  .||.|::|:|:|||.|||||||.||
  Rat   517 DAYMVVGGVPVPVESHAQRVANFALGMRISA--KEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKM 579

  Fly   577 PRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEF----ELQPRDPSFLPKEFPNPG 637
            |||||||.:|..|::.||.....|:::|||....| |::|||.    |::.:..
  Rat   580 PRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRAL-KNKGFEIVRRGEIEVKGK----------- 632

  Fly   638 GTETCYFL 645
            |..|.|||
  Rat   633 GKMTTYFL 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	34/140 (24%)
		HNOBA	259..451	CDD:285003	52/194 (27%)
		CYCc	430..619	CDD:214485	86/191 (45%)
		Guanylate_cyc	457..647	CDD:278633	84/196 (43%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	40/160 (25%)
		HNOBA	267..453	CDD:285003	51/189 (27%)
		CYCc	432..622	CDD:214485	87/192 (45%)
		Guanylate_cyc	459..642	CDD:278633	84/196 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820