Protein Alignment Gycalpha99B and Gucy1b2

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: XP_011243363.2
• Gene: Gucy1b2 / 239134
• MGIID: 2660873
• Length: 829
• Species: Mus musculus
• Alignment Length: 667
• Identity: 201/667 - (30%)
• Similarity: 309/667 - (46%)
• Gaps: 102/667 - (15%)

  Fly    58 LNTAVTSLVAKY--RQNWPNIHKLKLDPQTFKSCANYDYLAD------IQELLLKMDEASASEIL 114
            :||.:.|||.:.  .:.|   .|||...:.......|....|      |||....:| .|...||
Mouse   118 INTCLQSLVTEKFGEETW---EKLKASAEVQDVFMTYTVYDDTITVKLIQEACKALD-VSMEAIL 178

  Fly   115 VLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVCAGEGE----L 175
            .|.||.....|.....:|..|.||.:|.||:.:||.::..|.|..:::....|...|..:    |
Mouse   179 KLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEGGADGAMRL 243

  Fly   176 IFTSERPVIAWLLLGSLKALTRMLYKVDVNIKI----EPVEGDARRYRYLFSLVKDNSQTMLMG- 235
            .:.|:|..:..::.|.::|:.:..:..||.:.|    |.||...::...:| ||...::..:.|
Mouse   244 HYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVF-LVVQKARRQIRGA 307

  Fly   236 ---RPTSVSKTI---PETVQ-------------------RSNSS--NAS---------------- 257
               ||.. |:.|   .|::|                   :|:|:  .||
Mouse   308 KVNRPRD-SENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKGPLGDTFQPVF 371

  Fly   258 --DLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKP--YMADFGCQATTYFDFKRPKGLTM 318
              .|.:....||..||:|.:.:|.|.:.|.|....| |.|  ....||..  .||....|: :|.
Mouse   372 PERLWIEEEVFCNAFPFHVVFDEALRVKQAGVNIQK-YVPGILTQKFGLD--EYFSIVHPQ-VTF 432

  Fly   319 KFRDIVRRTYTPFLIGLNN---PPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTC 380
            ....|.:...:.|::....   |......|.  |:::|||:.......::|:.||.|..|..|..
Mouse   433 NISSICKFINSQFILKTRREMMPEAWKSQPT--LKLRGQMIWMESLKCMVFMCSPKLRSLQELEE 495

  Fly   381 NGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPA 445
            :.:.:|||..||.||::||:.:|..|:..|..:::|.|..:...::.:..|:||..:||:.:.|.
Mouse   496 SKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPE 560

  Fly   446 EIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKV 510
            .:|.:|..|..:.|..:...||||||:|.||:||:...|..:::||..:|..||...:..|||||
Mouse   561 HVANQLKEGKKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTNIHDVYKV 625

  Fly   511 ETIGDAYCVASGLHRASIYDAHKVAWMALKM-IDACSKHITH--DGEQIKMRIGLHTGTVLAGVV 572
            |||||||.|..|:.......|.:||..||.| |.|  |.:.:  .||.|::|:|:|||.||||||
Mouse   626 ETIGDAYMVVGGVPVPVESHAQRVANFALGMRISA--KEVMNPVTGEPIQIRVGIHTGPVLAGVV 688

  Fly   573 GRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEF----ELQPRDPSFLPKEF 633
            |.|||||||||.:|..|::.||.....|:::|||....| :::|||.    |::.:..
Mouse   689 GDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRAL-ENKGFEIVTRGEIEVKGK------- 745

  Fly   634 PNPGGTETCYFLESFRN 650
                |..|.|||  .||
Mouse   746 ----GKMTTYFL--IRN 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	27/102 (26%)
		HNOBA	259..451	CDD:462234	54/196 (28%)
		Guanylate_cyc	457..647	CDD:425528	83/196 (42%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:462233	42/161 (26%)
		HNOBA	380..566	CDD:462234	53/191 (28%)
		Guanylate_cyc	572..754	CDD:425528	83/197 (42%)