DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001028494.1	Gene:	Gucy1a2 / 234889	MGIID:	2660877	Length:	730	Species:	Mus musculus

Alignment Length:	710	Identity:	261/710 - (36%)
Similarity:	384/710 - (54%)	Gaps:	98/710 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CPFFRRADSLTRQPSVIAEPGGHWALEDEELSDDA------------------------LTLTHL 43
            ||..|...:.:|.|     ||...:.|..:.:..|                        :.|..|
Mouse    29 CPLSRLCWNGSRSP-----PGPPGSREAAKAATSAPAASAAAASAAVAAEYKRAQRRGRVNLDSL 88

  Fly    44 QMAIQLLTAPSNEDLNTAVTSL-------VAKYRQNWPNIHKLKLDPQTFKSC-----ANYDYLA 96
            ..:|.|||||..:.::..:...       |..||....|.|.:.      |.|     :|.:.:.
Mouse    89 GESISLLTAPLPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNIS------KRCSYADHSNKEEIE 147

  Fly    97 DIQELLLKMDEASAS-------EILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDV 154
            |:..:|    :.:|:       ||....|||....|... .||..|.:|:.||:|....|.:.:.
Mouse   148 DVSGIL----QCTANVLGLQFQEIQERFGEEFFKICFDE-NERVLRAVGSTLQDFFNGFDALLEH 207

  Fly   155 LKL---QEEDVTDTGFVC--AGEGELIFTSERP--VIAWLLLGSLKALTRMLYKVDVNIKIEPVE 212
            ::.   ::..:..:.|:|  ..||.|:.....|  .:.:.:||.:||..:.:|  .:|:::|.:|
Mouse   208 IRTSFGKQATLESSSFLCKELPEGTLMLHYFHPHHTVGFAMLGMIKAAGKRIY--HLNVEVEQIE 270

  Fly   213 GDARRYRYLFSLVKDNSQ-------TMLMG--RPTSVSKTIPETVQRSNSSNASDLQMNSSSFCK 268
            .:        .|..|.|.       |.|:.  ..|.::|..|:    ..|...:||:::.::||:
Mouse   271 NE--------KLCFDGSNPSNCSCLTFLIKECETTQITKDNPQ----GTSQVPADLRISINTFCR 323

  Fly   269 MFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLI 333
            .||:|.:.:..:.::|||.|..|..: |......:....|:...|. :...|..::.|..|||:|
Mouse   324 AFPFHLMFDSNMVVLQLGEGLRKQLR-YDTHRALKFEDCFEIVSPM-INATFDRVLLRLSTPFVI 386

  Fly   334 GLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVI 398
            .........:.....:||||||:|.|||:::||:|||.:|.||.|...||.:||||:|||||:||
Mouse   387 RTKPEASGTENEDKVMEIKGQMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVI 451

  Fly   399 LVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYP 463
            ||||||:|||||::||||:|.::|..:.|:.:|:||.|.||:.|||.::|::||.|..:.|:.:.
Mouse   452 LVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD 516

  Fly   464 DVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASI 528
            |||:|||||||||:||::.||..|||||..||..||..|...|:||||||||||||||||||.|:
Mouse   517 DVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSL 581

  Fly   529 YDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFE 593
            ..|..:|.|||||::...:.:|.||:.|:||||:|:|:|||||||.:||||||||::||:|:|||
Mouse   582 CHAKPIALMALKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFE 646

  Fly   594 SGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPN--PGGTETCYFLESFRNP 651
            |||...:|||||||...|.:.:.|.|  .||....||..||.  ||   .|||||...:|
Mouse   647 SGSHPRRINVSPTTYQLLKREDSFTF--IPRSREELPDNFPKEIPG---VCYFLELRTDP 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	33/150 (22%)
		HNOBA	259..451	CDD:285003	80/191 (42%)
		CYCc	430..619	CDD:214485	110/188 (59%)
		Guanylate_cyc	457..647	CDD:278633	110/191 (58%)
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002	27/113 (24%)
		HNOBA	314..501	CDD:285003	79/188 (42%)
		CYCc	483..672	CDD:214485	110/188 (59%)
		Guanylate_cyc	512..696	CDD:278633	109/188 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2953
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H47953
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1867
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	1	1.000	-	-		FOG0008257
OrthoInspector	1	1.000	-	-		otm43925
orthoMCL	1	0.900	-	-		OOG6_106420
Panther	1	1.100	-	-	O	PTHR45655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4585
SonicParanoid	1	1.000	-	-		X3073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860