Protein Alignment Gycalpha99B and gcy-27

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001255957.2
• Gene: gcy-27 / 191654
• WormBaseID: WBGene00001550
• Length: 616
• Species: Caenorhabditis elegans
• Alignment Length: 705
• Identity: 152/705 - (21%)
• Similarity: 256/705 - (36%)
• Gaps: 208/705 - (29%)

  Fly    60 TAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELL---LKMDEASASEILVLLGEEL 121
            |.:.....||:..|      |:..::.|...|.:..|.:|..|   ...|||:|
 Worm    22 TVIGENTRKYKMTW------KVPKESLKIIVNKNADARMQRELENRTAKDEANA----------- 69

  Fly   122 ITCCCTGIIER-----AFRCLGTDLQEFL------------GSLDGVYDVLKLQEEDVTDTGFVC 169
                   :..|     ::..:||...||:            .|||.:|::.:|:.:::.:
 Worm    70 -------LTSRRRVFGSYALIGTQRAEFIQFRQIKHIDITNASLDFLYNLKQLKHDNLAN----- 122

  Fly   170 AGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNS-QTML 233
                                         .|.:.:|       .|......|.:||:..: :...
 Worm   123 -----------------------------FYGIQLN-------DDLNTMTILHALVERGTLEEFC 151

  Fly   234 MGRPTSVSKTIPETVQRSNSSNASDLQMNSSSF--------CKMFPWHFIMNEQLELVQLGRGFS 290
            :.|...:.:|......|........|.::..::        |.:     .:|..|::...|
 Worm   152 LDRDFGMDETFKSAFMRDILKGLQYLHLSPVAYHGHLHAATCLI-----DINWVLKIALYG---- 207

  Fly   291 KLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPP---------------- 339
                  :.:|.|.   .||   .:.:||..|.....:|..::.   .||
 Worm   208 ------VTNFVCD---NFD---AENITMPDRSDYTISYAQYVC---FPPEHIREYDATGKLPTRF 257

  Fly   340 ------------GAVDFPAIGLEIKGQMVHC---PESNSLLFIGS----PFLDG--------LDG 377
                        |.:.:..|..|...:::|.   |.|..::.|..    ||:..        ||
 Worm   258 VRGSKQGDIYCVGMIFYMMIEREDPYRLIHSVERPGSGLMMEILDHNLMPFISNNETQEDTLLD- 321

  Fly   378 LTCNGLFISD---IPLHDATREVILV---GEQARAQDGLRRRMDKIKNSIE---EANSA-VTKER 432
             .|...:..|   .|..:..|..|.:   ..:....|.:.|..:|..:.:|   .|.|| :...:
 Worm   322 -KCKECWNRDPEKRPTIENLRNAIAICYADSKGNLIDQMIRMNEKYADELETLVAARSADLALAQ 385

  Fly   433 KKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKD 497
            .:.:.||:.:.||.||:.|..|....|::|...|::|..|..|..|..|..|..||..|..::..
 Worm   386 MQTMRLLNEMLPASIAKDLKNGVIAPARSYASATVMFVQICDFIVILKRRPPKEVIGFLNDIFDQ 450

  Fly   498 FDEFCDFFDVYKVETIGDAYCVASGLHRAS----IYDAHKVAWMALKMIDACSKHITHDGE---Q 555
            ||......|.|||||.|:.|.||||:...:    :::   ||.|:|: |.|.|...|.:.:   :
 Worm   451 FDTVIKRHDAYKVETTGETYMVASGVPNENEGRHVFE---VAEMSLE-IRAISLSYTLENDKNYK 511

  Fly   556 IKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSP-TTKDWLTKHEGFEF 619
            :::|||.|.|.:.|||:|.|.|||||||.:|..|::.:|....|:|..|. |.:..|..|   |:
 Worm   512 LRVRIGFHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQTSEITARMLLATH---EY 573

  Fly   620 ELQPRDPSFLPKEFPNPGGTETCYFLESFRNPALDSELPLVEHINVSMKTISEGG 674
            :|..|....:..:     |...||:|.              |||:.. :.|.|.|
 Worm   574 KLVKRGIVHVKGK-----GEVNCYWLN--------------EHIHKD-EEIEESG 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	13/115 (11%)
		HNOBA	259..451	CDD:462234	44/252 (17%)
		Guanylate_cyc	457..647	CDD:425528	67/197 (34%)
gcy-27	NP_001255957.2	Protein Kinases, catalytic domain	75..338	CDD:473864	47/329 (14%)
		CYCc	383..573	CDD:214485	68/196 (35%)