DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and gcy-27

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001255957.2	Gene:	gcy-27 / 191654	WormBaseID:	WBGene00001550	Length:	616	Species:	Caenorhabditis elegans

Alignment Length:	705	Identity:	152/705 - (21%)
Similarity:	256/705 - (36%)	Gaps:	208/705 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 TAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELL---LKMDEASASEILVLLGEEL 121
            |.:.....||:..|      |:..::.|...|.:..|.:|..|   ...|||:|
Worm    22 TVIGENTRKYKMTW------KVPKESLKIIVNKNADARMQRELENRTAKDEANA----------- 69

  Fly   122 ITCCCTGIIER-----AFRCLGTDLQEFL------------GSLDGVYDVLKLQEEDVTDTGFVC 169
                   :..|     ::..:||...||:            .|||.:|::.:|:.:::.:
Worm    70 -------LTSRRRVFGSYALIGTQRAEFIQFRQIKHIDITNASLDFLYNLKQLKHDNLAN----- 122

  Fly   170 AGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNS-QTML 233
                                         .|.:.:|       .|......|.:||:..: :...
Worm   123 -----------------------------FYGIQLN-------DDLNTMTILHALVERGTLEEFC 151

  Fly   234 MGRPTSVSKTIPETVQRSNSSNASDLQMNSSSF--------CKMFPWHFIMNEQLELVQLGRGFS 290
            :.|...:.:|......|........|.::..::        |.:     .:|..|::...|
Worm   152 LDRDFGMDETFKSAFMRDILKGLQYLHLSPVAYHGHLHAATCLI-----DINWVLKIALYG---- 207

  Fly   291 KLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPP---------------- 339
                  :.:|.|.   .||   .:.:||..|.....:|..::.   .||
Worm   208 ------VTNFVCD---NFD---AENITMPDRSDYTISYAQYVC---FPPEHIREYDATGKLPTRF 257

  Fly   340 ------------GAVDFPAIGLEIKGQMVHC---PESNSLLFIGS----PFLDG--------LDG 377
                        |.:.:..|..|...:::|.   |.|..::.|..    ||:..        ||
Worm   258 VRGSKQGDIYCVGMIFYMMIEREDPYRLIHSVERPGSGLMMEILDHNLMPFISNNETQEDTLLD- 321

  Fly   378 LTCNGLFISD---IPLHDATREVILV---GEQARAQDGLRRRMDKIKNSIE---EANSA-VTKER 432
             .|...:..|   .|..:..|..|.:   ..:....|.:.|..:|..:.:|   .|.|| :...:
Worm   322 -KCKECWNRDPEKRPTIENLRNAIAICYADSKGNLIDQMIRMNEKYADELETLVAARSADLALAQ 385

  Fly   433 KKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKD 497
            .:.:.||:.:.||.||:.|..|....|::|...|::|..|..|..|..|..|..||..|..::..
Worm   386 MQTMRLLNEMLPASIAKDLKNGVIAPARSYASATVMFVQICDFIVILKRRPPKEVIGFLNDIFDQ 450

  Fly   498 FDEFCDFFDVYKVETIGDAYCVASGLHRAS----IYDAHKVAWMALKMIDACSKHITHDGE---Q 555
            ||......|.|||||.|:.|.||||:...:    :::   ||.|:|: |.|.|...|.:.:   :
Worm   451 FDTVIKRHDAYKVETTGETYMVASGVPNENEGRHVFE---VAEMSLE-IRAISLSYTLENDKNYK 511

  Fly   556 IKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSP-TTKDWLTKHEGFEF 619
            :::|||.|.|.:.|||:|.|.|||||||.:|..|::.:|....|:|..|. |.:..|..|   |:
Worm   512 LRVRIGFHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQTSEITARMLLATH---EY 573

  Fly   620 ELQPRDPSFLPKEFPNPGGTETCYFLESFRNPALDSELPLVEHINVSMKTISEGG 674
            :|..|....:..:     |...||:|.              |||:.. :.|.|.|
Worm   574 KLVKRGIVHVKGK-----GEVNCYWLN--------------EHIHKD-EEIEESG 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	22/151 (15%)
		HNOBA	259..451	CDD:285003	44/252 (17%)
		CYCc	430..619	CDD:214485	68/196 (35%)
		Guanylate_cyc	457..647	CDD:278633	67/197 (34%)
gcy-27	NP_001255957.2	PKc_like	75..338	CDD:304357	47/329 (14%)
		CYCc	383..573	CDD:214485	68/196 (35%)
		Guanylate_cyc	411..595	CDD:278633	66/195 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910