DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and gcy-19

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001348702.1	Gene:	gcy-19 / 191650	WormBaseID:	WBGene00001544	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	686	Identity:	163/686 - (23%)
Similarity:	263/686 - (38%)	Gaps:	187/686 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 WALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCA 90
            :.:..:.|..|.:. ...|:.:..|.||...|........:.....|..:..|:..| .||   :
Worm   534 YVMRQKRLERDRID-AEWQIPLVKLQAPPKRDKERMSKRSLQSGPSNITDTSKMTFD-NTF---S 593

  Fly    91 NYD-YLADIQELLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDV 154
            ||. :..|.:.:|.....||                         ..:.||...|:       .:
Worm   594 NYSIFYLDKEPVLSTAHPAS-------------------------NLIRTDYDTFV-------RL 626

  Fly   155 LKLQEEDVTD-TGFVCAGEGELIFTSERPVIAWLLL--GSLKALTRMLYKVDV----NIKIEPVE 212
            .||..|:|.. .|....|...|        ..|.|.  |||:         |:    |..|:|.
Worm   627 RKLDHENVNKFVGMSIDGPEYL--------AVWKLCMRGSLQ---------DIIGQGNFSIDPF- 673

  Fly   213 GDARRYRYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMN 277
                   ::|.:::|                           .|..|:...:||..:   |..:.
Worm   674 -------FMFCVIRD---------------------------MAEGLKYLHNSFLHV---HANLR 701

  Fly   278 EQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFR------DIVRRTYTPFLI--- 333
            ....||      ::.::..:.|||  ..|..:.|:|    ||.|      :::|.|..|..|
Worm   702 SGTVLV------NESWQAKLTDFG--LGTLAEEKKP----MKRRQLWMAPEVIRGTLLPHQIEKS 754

  Fly   334 --------------------GLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGL 378
                                .:......||  .|...||....:.|.         |.|| :||:
Worm   755 ADIYSLAVIASEVLTRKEAWNMAERKDTVD--EIVYRIKKGGPNAPR---------PELD-MDGV 807

  Fly   379 TCN-GLFI------SDIPLHDATREVI--LVGEQARAQDGLRRRMDKIKN-----------SIEE 423
            ..| .|.|      |:.|....:.:||  |:......:..|   ||.:.|           .:|:
Worm   808 EINHNLLILIRDCWSEEPADRPSADVICNLLKNMMPKKGNL---MDHVFNILEDYTTNLEVEVED 869

  Fly   424 ANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVI 488
            ....:|.|:||...||..:.|.::||:|..|.:::.:.:..||:.|||:|.||.:.::.:||.|:
Worm   870 RTKELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVV 934

  Fly   489 SMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAH--KVAWMALKMIDAC-SKHIT 550
            ::|..||.:||...:....||||:|||.|...|||...: .:||  ::..::|..:..| |..|.
Worm   935 NLLNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKN-GNAHIKQIVELSLDFMSYCKSFKIP 998

  Fly   551 H-DGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKH 614
            | ..|::::|||:::|..:|||||..||||||||.:|..|::.||..:|..|::|..:...|.||
Worm   999 HLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMKH 1063

  Fly   615 EGFEFELQPRDPSFLPKEFPNPGGTETCYFLESFRN 650
            ...::....|....:    ...|..||.:..|  ||
Worm  1064 YPNQYNTASRGDVII----KGKGVMETFWVFE--RN 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	27/139 (19%)
		HNOBA	259..451	CDD:285003	52/240 (22%)
		CYCc	430..619	CDD:214485	72/192 (38%)
		Guanylate_cyc	457..647	CDD:278633	66/193 (34%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347
		PKc_like	571..841	CDD:328722	71/384 (18%)
		CYCc	876..1065	CDD:214485	72/189 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810