DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and gcy-17

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	820	Identity:	189/820 - (23%)
Similarity:	301/820 - (36%)	Gaps:	264/820 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VIAEPGGHWALEDEELSDDALTL----THLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHK 78
            |:.|.||.|....|...||:.|.    :...|| .||....|..:|..||.....:.:|  .|..
Worm   268 VVEEVGGKWHYLWEGKFDDSDTFSTEDSRTSMA-NLLFLVDNMGMNNVVTPQYLNFSKN--VIEM 329

  Fly    79 LKLDP---------QTFKSCANY-DYLADI----------------------------------- 98
            :|.:|         :.:.|.|.| ..|||.
Worm   330 MKDEPFNCVEDCVGEEYSSVAKYAGQLADAFYAYAVAVNRLLTANPQAEIRNGTMILRNIGMTFE 394

  Fly    99 ----QELLLKMDEASASEILV--------------------------LLGEELI----------- 122
                .:|.:..|.|..|||::                          |..:|::
Worm   395 GVGGGDLTVDPDSARTSEIIMIGLNSSRLPETYGKLIINNQSVHFEQLYSDEVMDVWNGRQRPKA 459

  Fly   123 --TCCCTGIIERAFRCLGTDLQEFL---------------GSLDGVYDVLKLQEEDVTDTGFVCA 170
              ||..||.     :|....::::|               .::..|:..::.:.:::.....:..
Worm   460 KPTCGFTGT-----QCPPDFVRDYLVIVIIIVMFLIFAVSAAVGAVFYAIRQKRKEIERQDELWH 519

  Fly   171 GEGELI---------------FTSERPVIAWLLLGSLKALTRM---LYKVDVNIKIEPVEGDAR- 216
            .|...:               |.|.......|.:.|....||.   :|:|..|..:...:.|.|
Worm   520 VEASHLKPISKKSKSEASQRSFASGPSTSTKLTVESRTETTRFIFYIYQVRNNEVVAANKHDFRP 584

  Fly   217 --------RYRYLFSLVKD----------NSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNS 263
                    ..|.:.||..|          |||.:|.........::.:.:.||:      :||:|
Worm   585 QLTDVERSELRQMRSLDHDNLNKFIGLCLNSQQLLSIWRYCSRGSLADVISRSS------MQMDS 643

  Fly   264 SSFCKMFPWHFIMNEQLELVQLGRGF---SKL----------------YKPYMADFGCQATTYFD 309
                      |.|...:..:..|.||   |.|                ::..::|||.......|
Worm   644 ----------FFMLSLIRDIANGLGFIHTSMLHFHGYLSSRSCLIDDRWQVKISDFGLNEVRGMD 698

  Fly   310 --------FKRP---KGLTMKFR------------DIVRRTYTPFLIGLNNPPGAV-------DF 344
                    :..|   :||..:.:            :::.|:....|......|..:       .|
Worm   699 KLSTENMLWWAPEVLRGLEQRSKEADIYSFGIICSEVITRSSAFDLENRKEKPEEIIYQLKKGGF 763

  Fly   345 PAI--------GLEIKGQMVH----CPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREV 397
            .||        .|||...:||    |       :...|               |:.|..|..|.:
Worm   764 NAIRPSLLTDEALEINPALVHLIRDC-------WTEKP---------------SERPPIDQVRSL 806

  Fly   398 IL---VGEQARAQDGLRRRMDKIKNSIEEANSAVTK----ERKKNVSLLHLIFPAEIAEKLWLGS 455
            :.   .|::....|.:...::...:::||..:..||    |:||:..||:.:.|..:||||..|.
Worm   807 LRGMNDGKKGNLMDHVFNMLETYASTLEEEVNERTKELVEEQKKSDVLLYRMLPKTVAEKLKAGI 871

  Fly   456 SIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVA 520
            ||:.:|:..|||.|||:|.||::.|:.||..|:.:|..||..||...:..||||||||||.|...
Worm   872 SIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQNDVYKVETIGDGYLCV 936

  Fly   521 SGLHRASIYDAHK-VAWMALKMIDACSK-HITH-DGEQIKMRIGLHTGTVLAGVVGRKMPRYCLF 582
            |||...:.:|..| :|.|:|..:.:.:: .:.| ..|:|.:|||::.|:|:|||||..|||||||
Worm   937 SGLPHRNGHDHIKHIARMSLAFLSSLAEFRVAHMPSERINLRIGINCGSVVAGVVGLTMPRYCLF 1001

  Fly   583 GHSVTIANKFESGSEALKINVSPTTKDWLTKH--EGFEFE 620
            |.:|..|::.||..:..:|:||......|| |  .||..|
Worm  1002 GDAVNTASRMESNGKPGRIHVSSEANHLLT-HVVGGFRTE 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	34/252 (13%)
		HNOBA	259..451	CDD:285003	48/259 (19%)
		CYCc	430..619	CDD:214485	85/197 (43%)
		Guanylate_cyc	457..647	CDD:278633	73/169 (43%)
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141	28/138 (20%)
		ANF_receptor	47..398	CDD:279440	27/132 (20%)
		PKc_like	539..808	CDD:304357	55/306 (18%)
		Pkinase	567..803	CDD:278497	48/273 (18%)
		HNOBA	<824..867	CDD:285003	12/42 (29%)
		CYCc	846..1038	CDD:214485	83/192 (43%)
		Guanylate_cyc	873..1060	CDD:278633	73/169 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810