DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and phlp-2

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	301	Identity:	64/301 - (21%)
Similarity:	101/301 - (33%)	Gaps:	113/301 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLA 96
            :|..|...|..||...::||. |:|:|.|..||..
Worm    71 QLKSDTSPLAILQDFCRILTM-SDENLETESTSKA------------------------------ 104

  Fly    97 DIQELLLKMDEASASEIL-VLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEE 160
             ::::|...|..:...|. ..||...|         ||...|..|:               |.||
Worm   105 -LEDILSYTDSPAFRHIFSFFLGRPRI---------RAKSTLNLDI---------------LSEE 144

  Fly   161 DVTDTGFVCAGEGELIFTSERPVIAWLLLGSL---------------KALTRMLYKVDVNIKIEP 210
                   |...:|:||.|       |....::               :||.....||||:
Worm   145 -------VVIRKGKLIHT-------WQNARAVFYNSNIRLQTKNNQDEALQIRNMKVDVH----- 190

  Fly   211 VEGDARRYRYLFSLVKDNSQTMLMGRPTSVSK--TIPETVQRSNSSNASDLQMNSSSFCKMFPWH 273
               :::|.|.|.....|....::..||..:..  |..:.|::||..:|||.|:.      :.|..
Worm   191 ---ESKRGRALRLKDDDVCYLIIFQRPNILEAWLTRAQQVEKSNHVDASDEQLT------LIPEQ 246

  Fly   274 FIMNE-QLELVQLGRGFSKLYKP----YMADFGCQATTYFD 309
            .:.|| :::::.|.|. |.:.:|    .||..|     |.|
Worm   247 ILNNEARVQILNLRRN-SLISRPPTEKSMAPLG-----YID 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	25/147 (17%)
		HNOBA	259..451	CDD:285003	13/56 (23%)
		CYCc	430..619	CDD:214485
		Guanylate_cyc	457..647	CDD:278633
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	7/26 (27%)
		leucine-rich repeat	254..288	CDD:275380	9/34 (26%)
		PLN00113	283..>718	CDD:331614
		leucine-rich repeat	289..311	CDD:275380
		leucine-rich repeat	312..334	CDD:275380
		leucine-rich repeat	335..357	CDD:275380
		leucine-rich repeat	358..379	CDD:275380
		leucine-rich repeat	380..440	CDD:275380
		leucine-rich repeat	441..485	CDD:275380
		leucine-rich repeat	486..508	CDD:275380
		leucine-rich repeat	509..534	CDD:275380
		leucine-rich repeat	554..577	CDD:275380
		leucine-rich repeat	578..602	CDD:275380
		leucine-rich repeat	603..625	CDD:275380
		leucine-rich repeat	626..649	CDD:275380
		leucine-rich repeat	650..672	CDD:275380
		leucine-rich repeat	673..694	CDD:275380
		PP2Cc	754..985	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900